scholarly journals O-1602, an Agonist of Atypical Cannabinoid Receptors GPR55, Reverses the Symptoms of Depression and Detrusor Overactivity in Rats Subjected to Corticosterone Treatment

2020 ◽  
Vol 11 ◽  
Author(s):  
Andrzej Wróbel ◽  
Anna Serefko ◽  
Aleksandra Szopa ◽  
Daniela Ulrich ◽  
Ewa Poleszak ◽  
...  
Keyword(s):  
Detrusor Overactivity ◽  
Cannabinoid Receptors ◽  
Symptoms Of Depression ◽  
Corticosterone Treatment

The role of the peripheral cannabinoid system in the pathogenesis of detrusor overactivity evoked by increased intravesical osmolarity in rats

2015 ◽  
Vol 93 (8) ◽  
pp. 721-726 ◽  
Author(s):  
Kajetan Juszczak ◽  
Piotr Maciukiewicz
Keyword(s):  
Urinary Bladder ◽  
Detrusor Overactivity ◽  
Cannabinoid Receptors ◽  
Bladder Capacity ◽  
Pressure Profile ◽  
Intravesical Instillation ◽  
Motility Index ◽  
Urinary Bladder Dysfunction ◽  
Cb2 Receptors ◽  
Cb1 And Cb2 Receptors

The cannabinoid receptors CB1 and CB2 are localized in the urinary bladder and play a role in the regulation of its function. We investigated the pathomechanisms through which hyperosmolarity induces detrusor overactivity (DO). We compared urinary bladder activity in response to blockade of CB1 and CB2 receptors using AM281 and AM630, respectively, in normal rats and after hyperosmolar stimulation. Experiments were performed on 44 rats. DO was induced by intravesical instillation of hyperosmolar saline. Surgical procedures and cystometry were performed under urethane anaesthesia. The measurements represent the average of 5 bladder micturition cycles. We analysed basal, threshold, and micturition voiding pressure; intercontraction interval; compliance; functional bladder capacity; motility index; and detrusor overactivity index. The blockage of CB1 and CB2 receptors diminished the severity of hyperosmolar-induced DO. In comparison with naïve animals the increased frequency of voiding with no significant effect on intravesical voiding pressure profile was observed as a result of the blockage of CB1 and CB2 receptors. These results demonstrate that hyperosmolar-induced DO is mediated by CB1 and CB2 receptors. Therefore, the cannabinoid pathway could potentially be a target for the treatment of urinary bladder dysfunction.

scholarly journals A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1384 ◽  
Author(s):  
Andrzej Wróbel ◽  
Aleksandra Szopa ◽  
Anna Serefko ◽  
Ewa Poleszak
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Detrusor Overactivity ◽  
Cannabinoid Receptors ◽  
Female Rats ◽  
Retinyl Acetate ◽  
Urine Production ◽  
Bladder Diseases ◽  
The Impact

The aim of the research was to assess the impact of O-1602—novel GPR55 and GPR18 agonist—in the rat model of detrusor overactivity (DO). Additionally, its effect on the level of specific biomarkers was examined. To stimulate DO, 0.75% retinyl acetate (RA) was administered to female rats’ bladders. O-1602, at a single dose of 0.25 mg/kg, was injected intra-arterially during conscious cystometry. Furthermore, heart rate, blood pressure, and urine production were monitored for 24 h, and the impact of O-1602 on the levels of specific biomarkers was evaluated. An exposure of the urothelium to RA changed cystometric parameters and enhanced the biomarker levels. O-1602 did not affect any of the examined cystometric parameters or levels of biomarkers in control rats. However, the O-1602 injection into animals with RA-induced DO ameliorated the symptoms of DO and caused a reversal in the described changes in the concentration of CGRP, OCT3, BDNF, and NGF to the levels observed in the control, while the values of ERK1/2 and VAChT were significantly lowered compared with the RA-induced DO group, but were still statistically higher than in the control. O-1602 can improve DO, and may serve as a promising novel substance for the pharmacotherapy of bladder diseases.

1527: Can Detrusor Overactivity Affects Bladder Sensation During Repeated Filling Cystometry?

2007 ◽  
Vol 177 (4S) ◽  
pp. 504-504
Author(s):  
Woon Tsang ◽  
John O'Donoghue ◽  
James Moore ◽  
Anup Yadav ◽  
Bridget Harris ◽  
...  
Keyword(s):  
Detrusor Overactivity ◽  
Bladder Sensation

161: Corticotropin Releasing Factor (CRF) Receptor-1 is Expressed in Bladder Afferents and May be Important in Detrusor Overactivity

2006 ◽  
Vol 175 (4S) ◽  
pp. 52-52
Author(s):  
Seema Sharma ◽  
Adam P. Klausner ◽  
Sang-Kuk Yang ◽  
Hwancheol Son ◽  
Jeremy B. Tuttle ◽  
...  
Keyword(s):  
Detrusor Overactivity ◽  
Corticotropin Releasing Factor ◽  
Bladder Afferents

1265: ATP Released from the Urothelium of Bladder with Idiopathic Detrusor Overactivity

2006 ◽  
Vol 175 (4S) ◽  
pp. 407-407
Author(s):  
Vivek Kumar ◽  
Christopher Chapple ◽  
Derek Rosario ◽  
Russell Chess-Williams
Keyword(s):  
Detrusor Overactivity ◽  
Idiopathic Detrusor Overactivity

1698: Why Aren't all Older Adults with Detrusor Overactivity Incontinent?

2004 ◽  
Vol 171 (4S) ◽  
pp. 449-449
Author(s):  
Lisa J. Rosenberg ◽  
Derek J. Griffiths ◽  
Neil M. Resnick
Keyword(s):  
Older Adults ◽  
Detrusor Overactivity

1245: Role of C-Afferent Fibers and Monitoring of Intra Vesical Resiniferatoxin Therapy for Patients with Idiopathic Detrusor Overactivity

2004 ◽  
Vol 171 (4S) ◽  
pp. 328-328
Author(s):  
Teruhiko Yokoyama ◽  
Kunihiro Nozaki ◽  
Osamu Fujita ◽  
Miyabi Inoue ◽  
Hiromi Kumon
Keyword(s):  
Detrusor Overactivity ◽  
Idiopathic Detrusor Overactivity ◽  
Afferent Fibers

532: Intravesical Resiniferatoxin Versus Botulinum-A Toxin Injections in Patients with Neurogenic Detrusor Overactivity: A Prospective Randomized Study

2004 ◽  
Vol 171 (4S) ◽  
pp. 142-142 ◽  
Author(s):  
Antonella Giannantoni ◽  
Savino M. Di Stasi ◽  
Robert L. Stephen ◽  
Gerardo Pizzirusso ◽  
Ettore Mearini ◽  
...  
Keyword(s):  
Detrusor Overactivity ◽  
Randomized Study ◽  
Prospective Randomized Study ◽  
Neurogenic Detrusor Overactivity ◽  
Botulinum A Toxin

Suicidal Behavior in German Adolescents

2015 ◽  
Vol 43 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Joana Straub ◽  
Ferdinand Keller ◽  
Nina Sproeber ◽  
Michael G. Koelch ◽  
Paul L. Plener
Keyword(s):  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Present Sample ◽  
Manic Symptoms ◽  
Symptoms Of Depression ◽  
Adolescent Sample ◽  
History Of ◽  
Sum Scores

Objective: Research in adults has identified an association between bipolar disorder and suicidal behavior. This relationship, however, has been insufficiently investigated in adolescents to date. Methods: 1,117 adolescents from 13 German schools (mean age = 14.83, SD = .63; 52.7% females) completed an extended German version of the Center for Epidemiological Studies Depression Scale (CES-D), which assesses depressive and manic symptoms during the last week, as well as the Self-Harm Behavior Questionnaire (SHBQ) for the assessment of lifetime suicidal behavior. Results: In the present sample 39.4% of the girls and 23.1% of the boys reported lifetime suicidal thoughts and 7.1% of the girls as well as 3.9% of the boys a lifetime history of suicide attempts. 18.7% of the adolescent sample revealed elevated symptoms of depression and 9% elevated levels of mania symptoms. Elevated sum scores of depression and mania were associated with a higher number of suicidal ideations and suicide attempts. A block-wise regression analysis revealed that sum scores of depression and mania predicted suicidal ideations best. Concerning suicide attempts, the best predictors were age as well as depression and mania sum scores. Conclusions: Suicidal behavior was reported more often when adolescents demonstrate symptoms of mania as well as symptoms of depression than when they demonstrate only depressive symptoms. The presence of bipolar symptoms in adolescents should alert clinicians to the heightened possibility of suicidal behavior.

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