scholarly journals Potential Mechanism of Dermal Wound Treatment With Preparations From the Skin Gel of Arabian Gulf Catfish: A Unique Furan Fatty Acid (F6) and Cholesta-3,5-Diene (S5) Recruit Neutrophils and Fibroblasts to Promote Wound Healing

2020 ◽  
Vol 11 ◽  
Author(s):  
Jassim M. Al-Hassan ◽  
Aleksander Hinek ◽  
Waleed M. Renno ◽  
Yanting Wang ◽  
Yuan Fang Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fatty Acid ◽  
Arabian Gulf ◽  
Wound Treatment ◽  
Potential Mechanism ◽  
Promote Wound Healing ◽  
Furan Fatty Acid ◽  
Dermal Wound

Reduction of number of postoperative complications depends on quality of dressing material and wound treatment

2020 ◽  
pp. 61-63
Author(s):  
Larisa Katkasova ◽  
Svetlana Kropotova
Keyword(s):  
At Risk ◽  
Wound Healing ◽  
Postoperative Complications ◽  
Wound Treatment ◽  
Postoperative Wound ◽  
Speed Up ◽  
Modern Technologies

Operated patients suffering from diabetes are at risk of developing postoperative complications. Modern technologies of postoperative wound treatment and modern dressings allow to avoid complications and speed up the process of postoperative wound healing.

A moisture balanced antibacterial dressing loaded with lysozyme possesses antibacterial activity and promotes wound healing

Soft Matter ◽  
2021 ◽  
Vol 17 (11) ◽  
pp. 3162-3173
Author(s):  
Ling Xiao ◽  
Wenqiang Ni ◽  
Xiaohong Zhao ◽  
Yicheng Guo ◽  
Xue Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Promote Wound Healing

An antibacterial moisture balanced dressing is designed to fight infection and promote wound healing.

scholarly journals Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus

2011 ◽  
Vol 108 (42) ◽  
pp. 17533-17537 ◽  
Author(s):  
T. Wakimoto ◽  
H. Kondo ◽  
H. Nii ◽  
K. Kimura ◽  
Y. Egami ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Perna Canaliculus ◽  
Furan Fatty Acid ◽  
Anti Inflammatory ◽  
Inflammatory Component

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1

2021 ◽  
pp. 105993
Author(s):  
Basma G. Eid ◽  
Nabil A. Alhakamy ◽  
Usama A. Fahmy ◽  
Osama A.A. Ahmed ◽  
Shadab Md ◽  
...  
Keyword(s):  
Wound Healing ◽  
Promote Wound Healing ◽  
Tgf Β1

scholarly journals Furanoid F-Acid F6 Uniquely Induces NETosis Compared to C16 and C18 Fatty Acids in Human Neutrophils

Biomolecules ◽  
2018 ◽  
Vol 8 (4) ◽  
pp. 144 ◽  
Author(s):  
Meraj Khan ◽  
Cecil Pace-Asciak ◽  
Jassim Al-Hassan ◽  
Mohammad Afzal ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Therapeutic Potential ◽  
Lipid Fraction ◽  
Arabian Gulf ◽  
Dienoic Acid ◽  
Neutrophil Extracellular Trap ◽  
Gas Chromatography Mass Spectrometry ◽  
Human Neutrophils ◽  
Long Chain

Various biomolecules induce neutrophil extracellular trap (NET) formation or NETosis. However, the effect of fatty acids on NETosis has not been clearly established. In this study, we focused on the NETosis-inducing ability of several lipid molecules. We extracted the lipid molecules present in Arabian Gulf catfish (Arius bilineatus, Val) skin gel, which has multiple therapeutic activities. Gas chromatography–mass spectrometry (GC-MS) analysis of the lipid fraction-3 from the gel with NETosis-inducing activity contained fatty acids including a furanoid F-acid (F6; 12,15-epoxy-13,14-dimethyleicosa-12,14-dienoic acid) and common long-chain fatty acids such as palmitic acid (PA; C16:0), palmitoleic acid (PO; C16:1), stearic acid (SA; C18:0), and oleic acid (OA; C18:1). Using pure molecules, we show that all of these fatty acids induce NETosis to different degrees in a dose-dependent fashion. Notably, F6 induces a unique form of NETosis that is rapid and induces reactive oxygen species (ROS) production by both NADPH oxidase (NOX) and mitochondria. F6 also induces citrullination of histone. By contrast, the common fatty acids (PA, PO, SA, and OA) only induce NOX-dependent NETosis. The activation of the kinases such as ERK (extracellular signal-regulated kinase) and JNK (c-Jun N-terminal kinase) is important for long-chain fatty acid-induced NETosis, whereas, in F-acid-induced NETosis, Akt is additionally needed. Nevertheless, NETosis induced by all of these compounds requires the final chromatin decondensation step of transcriptional firing. These findings are useful for understanding F-acid- and other fatty acid-induced NETosis and to establish the active ingredients with therapeutic potential for regulating diseases involving NET formation.

scholarly journals Ex vivoexpanded haematopoietic progenitor cells improve dermal wound healing by paracrine mechanisms

2009 ◽  
Vol 18 (5) ◽  
pp. 445-453 ◽  
Author(s):  
Christian Templin ◽  
Karsten Grote ◽  
Kai Schledzewski ◽  
Jelena-Rima Ghadri ◽  
Sabine Schnabel ◽  
...  
Keyword(s):  
Wound Healing ◽  
Progenitor Cells ◽  
Dermal Wound Healing ◽  
Dermal Wound

scholarly journals Augmentation of Dermal Wound Healing by Adipose Tissue-Derived Stromal Cells (ASC)

2018 ◽  
Vol 5 (4) ◽  
pp. 91 ◽  
Author(s):  
Joris van Dongen ◽  
Martin Harmsen ◽  
Berend van der Lei ◽  
Hieronymus Stevens
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Adipose Tissue ◽  
Stromal Cells ◽  
Randomized Clinical Trials ◽  
Cell Types ◽  
Matrix Remodeling ◽  
Skin Wound Healing ◽  
Dermal Wound Healing ◽  
Dermal Wound

The skin is the largest organ of the human body and is the first line of defense against physical and biological damage. Thus, the skin is equipped to self-repair and regenerates after trauma. Skin regeneration after damage comprises a tightly spatial-temporally regulated process of wound healing that involves virtually all cell types in the skin. Wound healing features five partially overlapping stages: homeostasis, inflammation, proliferation, re-epithelization, and finally resolution or fibrosis. Dysreguled wound healing may resolve in dermal scarring. Adipose tissue is long known for its suppressive influence on dermal scarring. Cultured adipose tissue-derived stromal cells (ASCs) secrete a plethora of regenerative growth factors and immune mediators that influence processes during wound healing e.g., angiogenesis, modulation of inflammation and extracellular matrix remodeling. In clinical practice, ASCs are usually administered as part of fractionated adipose tissue i.e., as part of enzymatically isolated SVF (cellular SVF), mechanically isolated SVF (tissue SVF), or as lipograft. Enzymatic isolation of SVF obtained adipose tissue results in suspension of adipocyte-free cells (cSVF) that lack intact intercellular adhesions or connections to extracellular matrix (ECM). Mechanical isolation of SVF from adipose tissue destructs the parenchyma (adipocytes), which results in a tissue SVF (tSVF) with intact connections between cells, as well as matrix. To date, due to a lack of well-designed prospective randomized clinical trials, neither cSVF, tSVF, whole adipose tissue, or cultured ASCs can be indicated as the preferred preparation procedure prior to therapeutic administration. In this review, we present and discuss current literature regarding the different administration options to apply ASCs (i.e., cultured ASCs, cSVF, tSVF, and lipografting) to augment dermal wound healing, as well as the available indications for clinical efficacy.

scholarly journals Nest Making and Oxytocin Comparably Promote Wound Healing in Isolation Reared Rats

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5523 ◽  
Author(s):  
Antonia Vitalo ◽  
Jonathan Fricchione ◽  
Monica Casali ◽  
Yevgeny Berdichevsky ◽  
Elizabeth A. Hoge ◽  
...  
Keyword(s):  
Wound Healing ◽  
Promote Wound Healing

Effects of CD100 promote wound healing in diabetic mice

2018 ◽  
Vol 49 (3) ◽  
pp. 277-287 ◽  
Author(s):  
Fang Wang ◽  
Bei Liu ◽  
Zhou Yu ◽  
Tong Wang ◽  
Yajuan Song ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Mice ◽  
Promote Wound Healing
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