scholarly journals Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering

2020 ◽  
Vol 11 ◽  
Author(s):  
Yunfan Zhang ◽  
Tingting Yu ◽  
Liying Peng ◽  
Qiannan Sun ◽  
Yan Wei ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Sustained Release ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Drug Sustained Release

scholarly journals Enhancement in sustained release of antimicrobial peptide and BMP-2 from degradable three dimensional-printed PLGA scaffold for bone regeneration

RSC Advances ◽  
2019 ◽  
Vol 9 (19) ◽  
pp. 10494-10507 ◽  
Author(s):  
Lei Chen ◽  
Liping Shao ◽  
Fengping Wang ◽  
Yifan Huang ◽  
Fenghui Gao
Keyword(s):  
Tissue Engineering ◽  
Sustained Release ◽  
Antimicrobial Peptide ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Three Dimensional ◽  
Plga Scaffold

One of the goals of bone tissue engineering is to create scaffolds with well-defined, inter-connected pores, excellent biocompatibility and osteoinductive ability.

3D printing mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds for bone repair

2018 ◽  
Vol 33 (6) ◽  
pp. 755-765 ◽  
Author(s):  
Jingwen Wu ◽  
Guohou Miao ◽  
Zhichao Zheng ◽  
Zhengmao Li ◽  
Wen Ren ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Sustained Release ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sodium Alginate ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Mesoporous Bioactive Glass

Drug delivery and release are a major challenge fabricating bone tissue engineering. In this study, we fabricated new sustained release hydrogel scaffolds composited of mesoporous bioactive glass, sodium alginate and gelatin by a three-dimensional printing technique. Naringin and calcitonin gene-related peptide were used as drugs to prepare drug-loaded scaffolds by direct printing or surface absorption. The physicochemical properties of the scaffolds and the drug release profiles of the two drug-loading models were investigated. We also examined the biocompatibility of the scaffolds, as well as the effect of the released medium on the proliferation and osteogenic differentiation of human osteoblast-like MG-63 cell. The results showed that the scaffolds had a high porosity (approximately 80%) with an interconnected cubic pore structure, rough surface morphology, bioactivity and strong biocompatibility. Furthermore, the naringin or calcitonin gene-related peptide co-printed into the scaffold displayed a steady sustained release behaviour for up to 21 days without an initial burst release, while both naringin and calcitonin gene-related peptide absorbed onto the surface of the scaffold were completely released within two days. MG-63 cells cultured with the extraction containing released drugs displayed promoted cell proliferation and the expression of osteogenesis-related genes more effectively compared with the drug-free extractions. Therefore, these results demonstrate that the developed mesoporous bioactive glass/sodium alginate/gelatin sustained release scaffolds provide a potential application for bone tissue engineering.

scholarly journals Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering

Biomaterials ◽  
2008 ◽  
Vol 29 (19) ◽  
pp. 2869-2877 ◽  
Author(s):  
Lauren S. Sefcik ◽  
Caren E. Petrie Aronin ◽  
Kristen A. Wieghaus ◽  
Edward A. Botchwey
Keyword(s):  
Tissue Engineering ◽  
Sustained Release ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Sphingosine 1 Phosphate
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