scholarly journals Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation

2020 ◽  
Vol 11 ◽  
Author(s):  
Surabhi Shukla ◽  
Babu L. Tekwani
Keyword(s):  
Neurodegenerative Diseases ◽  
Neuronal Differentiation ◽  
Histone Deacetylases ◽  
Histone Deacetylases Inhibitors

Neuroanatomical Profile of Antimaniac Effects of Histone Deacetylases Inhibitors

2011 ◽  
Vol 43 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Camila O. Arent ◽  
Samira S. Valvassori ◽  
Gabriel R. Fries ◽  
Laura Stertz ◽  
Camila L. Ferreira ◽  
...  
Keyword(s):  
Histone Deacetylases ◽  
Histone Deacetylases Inhibitors

scholarly journals The application of histone deacetylases inhibitors in glioblastoma

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Rui Chen ◽  
Mengxian Zhang ◽  
Yangmei Zhou ◽  
Wenjing Guo ◽  
Ming Yi ◽  
...  
Keyword(s):  
Histone Deacetylases ◽  
Histone Deacetylases Inhibitors

scholarly journals Cell reprogramming and neuronal differentiation applied to neurodegenerative diseases: Focus on Parkinson's disease

FEBS Letters ◽  
2015 ◽  
Vol 589 (22) ◽  
pp. 3396-3406 ◽  
Author(s):  
Shirley D. Wenker ◽  
Mariana Casalía ◽  
Verónica Cavaliere Candedo ◽  
Juan Cruz Casabona ◽  
Fernando J. Pitossi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Diseases ◽  
Neuronal Differentiation ◽  
Cell Reprogramming

scholarly journals Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the C. elegans Model

2021 ◽  
Vol 22 (22) ◽  
pp. 12263
Author(s):  
Anam Naseer ◽  
Snober Shabnam Mir ◽  
Krisztina Takacs-Vellai ◽  
Aamir Nazir
Keyword(s):  
Neurodegenerative Diseases ◽  
Histone Deacetylases ◽  
Vital Role ◽  
Model System ◽  
Dependent Manner ◽  
Class Iii ◽  
C Elegans ◽  
Cell Death Pathways ◽  
Protein Clearance ◽  
Multiple Processes

Age-associated neurodegenerative diseases are known to have “impaired protein clearance” as one of the key features causing their onset and progression. Hence, homeostasis is the key to maintaining balance throughout the cellular system as an organism ages. Any imbalance in the protein clearance machinery is responsible for accumulation of unwanted proteins, leading to pathological consequences—manifesting in neurodegeneration and associated debilitating outcomes. Multiple processes are involved in regulating this phenomenon; however, failure to regulate the autophagic machinery is a critical process that hampers the protein clearing pathway, leading to neurodegeneration. Another important and widely known component that plays a role in modulating neurodegeneration is a class of proteins called sirtuins. These are class III histone deacetylases (HDACs) that are known to regulate various vital processes such as longevity, genomic stability, transcription and DNA repair. These enzymes are also known to modulate neurodegeneration in an autophagy-dependent manner. Considering its genetic relevance and ease of studying disease-related endpoints in neurodegeneration, the model system Caenorhabditis elegans has been successfully employed in deciphering various functional outcomes related to critical protein molecules, cell death pathways and their association with ageing. This review summarizes the vital role of sirtuins and autophagy in ageing and neurodegeneration, in particular highlighting the knowledge obtained using the C. elegans model system.

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