scholarly journals Liquiritin Alleviates Pain Through Inhibiting CXCL1/CXCR2 Signaling Pathway in Bone Cancer Pain Rat

2020 ◽  
Vol 11 ◽  
Author(s):  
Huadong Ni ◽  
Miao Xu ◽  
Keyue Xie ◽  
Yong Fei ◽  
Housheng Deng ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain

Analgesic effects of microRNA‐129‐5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice

2018 ◽  
Vol 120 (3) ◽  
pp. 2876-2885 ◽  
Author(s):  
Shao‐Nan Yu ◽  
Gui‐Feng Liu ◽  
Long‐Yun Li ◽  
Guo‐Qing Zhao ◽  
Lin Liu ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Analgesic Effects

Activation of spinal TDAG8 and its downstream PKA signaling pathway contribute to bone cancer pain in rats

2012 ◽  
Vol 36 (1) ◽  
pp. 2107-2117 ◽  
Author(s):  
Li-Hua Hang ◽  
Jian-Ping Yang ◽  
Wei Yin ◽  
Li-Na Wang ◽  
Feng Guo ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain

scholarly journals Topical treatment with Xiaozheng Zhitong Paste alleviates bone cancer pain by inhibiting proteinase-activated receptor 2 signaling pathway

2015 ◽  
Vol 34 (3) ◽  
pp. 1449-1459 ◽  
Author(s):  
YANJU BAO ◽  
GAIMEI WANG ◽  
YEBO GAO ◽  
MAOBO DU ◽  
LIPING YANG ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathway ◽  
Topical Treatment ◽  
Bone Cancer ◽  
Bone Cancer Pain

Involvement of the spinal NMDA receptor/PKCγ signaling pathway in the development of bone cancer pain

2010 ◽  
Vol 1335 ◽  
pp. 83-90 ◽  
Author(s):  
Gu Xiaoping ◽  
Zhou XiaoFang ◽  
Zheng YaGuo ◽  
Zhang Juan ◽  
Wang JunHua ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Cancer Pain ◽  
Signaling Pathway ◽  
Bone Cancer ◽  
Bone Cancer Pain

scholarly journals Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Guiqin Zhu ◽  
Yanbin Dong ◽  
Xueming He ◽  
Ping Zhao ◽  
Aixing Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Dorsal Root Ganglion ◽  
Cancer Pain ◽  
Signaling Pathway ◽  
Dorsal Root ◽  
Mechanical Allodynia ◽  
Thermal Hyperalgesia ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Sprague Dawley

Radiotherapy is one of the major clinical approaches for treatment of bone cancer pain. Activation of cAMP-PKA signaling pathway plays important roles in bone cancer pain. Here, we examined the effects of radiotherapy on bone cancer pain and accompanying abnormal activation of cAMP-PKA signaling. Female Sprague-Dawley rats were used and received tumor cell implantation (TCI) in rat tibia (TCI cancer pain model). Some of the rats that previously received TCI treatment were treated with X-ray radiation (radiotherapy). Thermal hyperalgesia and mechanical allodynia were measured and used for evaluating level of pain caused by TCI treatment. PKA mRNA expression in dorsal root ganglion (DRG) was detected by RT-PCR. Concentrations of cAMP, IL-1β, and TNF-αas well as PKA activity in DRG and the spinal cord were measured by ELISA. The results showed that radiotherapy significantly suppressed TCI-induced thermal hyperalgesia and mechanical allodynia. The level of PKA mRNA in DRG, cAMP concentration and PKA activity in DRG and in the spinal cord, and concentrations of IL-1βand TNF-αin the spinal cord were significantly reduced by radiotherapy. In addition, radiotherapy also reduced TCI-induced bone loss. These findings suggest that radiotherapy may suppress bone cancer pain through inhibition of activation of cAMP-PKA signaling pathway in DRG and the spinal cord.

scholarly journals Electroacupuncture Attenuates Morphine Tolerance in Rats with Bone Cancer Pain by Inhibiting PI3K/Akt/JNK1/2 Signaling Pathway in the Spinal Dorsal Horn

2021 ◽  
Vol 20 ◽  
pp. 153473542199523
Author(s):  
Bin Jiang ◽  
Xuemei Zhong ◽  
Junfan Fang ◽  
Aijun Zhang ◽  
Wen WangD ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cancer Pain ◽  
Signaling Pathway ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Intrathecal Injection ◽  
Bone Cancer ◽  
Morphine Tolerance ◽  
Bone Cancer Pain ◽  
Spinal Dorsal

Purpose: Morphine is often used for the treatment of moderate and severe cancer pain, but long-term use can lead to morphine tolerance. Methods for effectively inhibiting morphine tolerance and the related mechanism of action are of great significance for the treatment of cancer pain. Previous studies have shown that electroacupuncture (EA) can inhibit the occurrence of morphine tolerance, but the mechanism is not yet clear. The aim of the present study was to explore the signaling pathway by which EA attenuates the development of bone cancer pain (BCP)-morphine tolerance (MT). Materials and methods: Changes in the paw withdrawal threshold (PWT) of rats with bone cancer pain-morphine tolerance were observed in a study of EA combined with intrathecal injection of a PI3K inhibitor (LY294002) or agonist (insulin-like growth factor-1 [IGF-1]). We also tested the protein expression of phosphorylated phosphatidylinositol 3-kinase (p-PI3K), phosphorylated protein kinase B (p-Akt), phosphorylated c-Jun NH2-terminal kinase 1/2 (p-JNK1/2), and β-arrestin2 in the L4-6 spinal dorsal horn of rats. Results: The protein expression of p-PI3K, p-Akt, p-JNK1/2, and β-arrestin2 was upregulated in the L4-6 spinal dorsal horn of rats with bone cancer pain and bone cancer pain-morphine tolerance. EA delayed the occurrence of morphine tolerance in rats with bone cancer pain and downregulated the protein expression of p-PI3K, p-Akt, p-JNK1/2, and β-arrestin2 in the L4-6 spinal dorsal horn of rats with bone cancer pain-morphine tolerance. Intrathecal injection of LY294002 attenuated the development of morphine tolerance and downregulated the protein expression of p-Akt, p-JNK1/2, and β-arrestin2 in the spinal dorsal horn of rats with bone cancer pain-morphine tolerance. In addition, the inhibitory effect of EA on morphine tolerance was reversed by IGF-1. Conclusion: The mechanism underlying the ability of EA to attenuate morphine tolerance may be associated with inhibition of the PI3K/Akt/JNK1/2 signaling pathway.

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