scholarly journals Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice

2020 ◽  
Vol 11 ◽  
Author(s):  
Daniela Baptista-de-Souza ◽  
Lígia Renata Rodrigues Tavares ◽  
Elke Mayumi Furuya-da-Cunha ◽  
Paulo Eduardo Carneiro de Oliveira ◽  
Lucas Canto-de-Souza ◽  
...  
Keyword(s):  
Aversive Situation ◽  
Chronic Fluoxetine

scholarly journals Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Science ◽  
2013 ◽  
Vol 340 (6137) ◽  
pp. 1234-1239 ◽  
Author(s):  
Susanne E. Ahmari ◽  
Timothy Spellman ◽  
Neria L. Douglass ◽  
Mazen A. Kheirbek ◽  
H. Blair Simpson ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Orbitofrontal Cortex ◽  
Progressive Increase ◽  
Repetitive Behaviors ◽  
Mouse Behavior ◽  
First Line ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Chronic Fluoxetine

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Increased grooming persisted for 2 weeks after stimulation cessation. The grooming increase was temporally coupled with a progressive increase in light-evoked firing of postsynaptic VMS cells. Both increased grooming and evoked firing were reversed by chronic fluoxetine, a first-line OCD treatment. Brief but repeated episodes of abnormal circuit activity may thus set the stage for the development of persistent psychopathology.

Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats

2007 ◽  
Vol 0 (0) ◽  
pp. 070905010742003-??? ◽  
Author(s):  
A. B. Marcussen ◽  
P. Flagstad ◽  
P. E. G. Kristjansen ◽  
F. F. Johansen ◽  
U. Englund
Keyword(s):  
Wistar Rats ◽  
Fluoxetine Treatment ◽  
Chronic Fluoxetine
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