scholarly journals Formulation and Characterization of Solid Lipid Nanoparticles Loading RF22-c, a Potent and Selective 5-LO Inhibitor, in a Monocrotaline-Induced Model of Pulmonary Hypertension

2020 ◽  
Vol 11 ◽  
Author(s):  
Angela Liparulo ◽  
Renata Esposito ◽  
Debora Santonocito ◽  
Alejandra Muñoz-Ramírez ◽  
Giuseppe Spaziano ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Nephrotoxicity of Albendazole and Albendazole-Loaded Solid Lipid Nanoparticles in Mice with Experimental Hydatidosis

2021 ◽  
Author(s):  
Kobra Kohansal ◽  
Abdollah Rafiei ◽  
Heibatullah Kalantari ◽  
Ali Jelowdar ◽  
Anayatollah Salimi ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Physicochemical Characterization ◽  
Public Health Problem ◽  
New Product ◽  
Lipid Nanoparticles ◽  
Control Group ◽  
Histopathological Study ◽  
Normal Range ◽  
Solid Lipid

Purposes: Cystic echinococcosis (CE) is a serious contemporary public health problem. Different CE treatment methods are of considerable importance, with albendazole (ABZ) being one of the most preferred drugs for CE treatment and prophylaxis. In this study, we evaluated the nephrotoxicity caused by ABZ and ABZ-loaded solid lipid nanoparticles (SLNs) in mice with experimental hydatid cyst. Methods: ABZ-loaded SLNs were produced by micro-emulsification and a high shear homogenization technique. Thereafter, we evaluated the physicochemical characterization of the product. Live protoscolices were injected into mice to induce experimental hydatidosis. Mice were then treated with ABZ and ABZ-loaded SLNs. The nephrotoxicity effects were evaluated by biochemical and histopathological surveys. Results: Significantly different blood urea nitrogen (BUN) levels were observed between the two infected groups (ABZ treatment and ABZ-loaded SLN treatment) and the control group. The kidney malondialdehyde (MDA) and glutathione (GSH) levels of the infected groups were not significantly different from those of the control group. The histopathological study revealed nephropathic and pathologic changes in the ABZ and ABZ-loaded SLN groups. Conclusion: ABZ formulated for ABZ-loaded SLNs had a more prominent chemoprophylactic efficacy on CE and fewer side effects than ABZ alone. Neither ABZ nor ABZ-loaded SLNs caused significant biochemical and histopathological defects on the kidney, and all functional biochemical markers stayed within the normal range. Therefore, ABZ-loaded SLNs could be a potential new product for CE treatment.

Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery

2014 ◽  
Vol 20 (4) ◽  
pp. 458-464 ◽  
Author(s):  
Biswaranjan Mohanty ◽  
Dipak K. Majumdar ◽  
Sagar K. Mishra ◽  
Amulya K. Panda ◽  
Soma Patnaik
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ocular Delivery ◽  
Solid Lipid
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