scholarly journals Uwhangchungsimwon, A Standardized Herbal Drug, Exerts an Anti-Depressive Effect in a Social Isolation Stress-Induced Mouse Model

2020 ◽  
Vol 10 ◽  
Author(s):  
Hyeon-Muk Oh ◽  
Jin-Seok Lee ◽  
Seo-Woo Kim ◽  
Young-Taeck Oh ◽  
Won-Yong Kim ◽  
...  
Keyword(s):  
Mouse Model ◽  
Social Isolation ◽  
Herbal Drug ◽  
Isolation Stress ◽  
Depressive Effect ◽  
Social Isolation Stress

scholarly journals Altered ADAR1 in mice affected by social isolation stress-induced cognitive deficits

2016 ◽  
Author(s):  
Wei Chen ◽  
Dong An ◽  
Hong Xu ◽  
Xiaoxin Cheng ◽  
Shiwei Wang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Expression ◽  
Western Blot ◽  
Frontal Cortex ◽  
Adenosine Deaminase ◽  
Social Isolation ◽  
Cognitive Deficits ◽  
Isolation Stress ◽  
Social Isolation Stress ◽  
Set Up

Adenosine deaminase acting on RNA (ADAR) activity increases in response to inflammation. Social isolation stress is related to neuroinflammation; however, it remains unclear whether ADAR1 is altered in response to social isolation stress-induced cognitive deficits. To investigate our hypothesis that ADAR1 displayed patterns of change in response to social isolation stress, we addressed this issue systemically by isolating Kunming mice for 2, 4 and 8 weeks individually since postnatal 21 days to set up isolation mouse model. Furthermore, we arranged re-socialization group to evaluate the alterations of ADAR1 in the cognitive deficits recovery. The results of behavior tests showed that social isolation stress resulted in cognitive dysfunction, which was recovered by re-socialization in re-gregarious rearing group. Furthermore, the immunohistochemistry and western blot results displayed that both the immunoreactivity and protein expression of ADAR1 in the hippocampus and frontal cortex increased obviously as compared to the same age mice without isolation. The above abnormal alterations of ADAR1 were recovered by re-socialization in re-gregarious rearing group. Our study supports the hypothesis that ADAR1 is altered in mice affected by social isolation stress-induced cognitive deficits.

scholarly journals Altered ADAR1 in mice affected by social isolation stress-induced cognitive deficits

2016 ◽  
Author(s):  
Wei Chen ◽  
Dong An ◽  
Hong Xu ◽  
Xiaoxin Cheng ◽  
Shiwei Wang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Protein Expression ◽  
Western Blot ◽  
Frontal Cortex ◽  
Adenosine Deaminase ◽  
Social Isolation ◽  
Cognitive Deficits ◽  
Isolation Stress ◽  
Social Isolation Stress ◽  
Set Up

Adenosine deaminase acting on RNA (ADAR) activity increases in response to inflammation. Social isolation stress is related to neuroinflammation; however, it remains unclear whether ADAR1 is altered in response to social isolation stress-induced cognitive deficits. To investigate our hypothesis that ADAR1 displayed patterns of change in response to social isolation stress, we addressed this issue systemically by isolating Kunming mice for 2, 4 and 8 weeks individually since postnatal 21 days to set up isolation mouse model. Furthermore, we arranged re-socialization group to evaluate the alterations of ADAR1 in the cognitive deficits recovery. The results of behavior tests showed that social isolation stress resulted in cognitive dysfunction, which was recovered by re-socialization in re-gregarious rearing group. Furthermore, the immunohistochemistry and western blot results displayed that both the immunoreactivity and protein expression of ADAR1 in the hippocampus and frontal cortex increased obviously as compared to the same age mice without isolation. The above abnormal alterations of ADAR1 were recovered by re-socialization in re-gregarious rearing group. Our study supports the hypothesis that ADAR1 is altered in mice affected by social isolation stress-induced cognitive deficits.

Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress

2017 ◽  
Vol 130 ◽  
pp. 200-210 ◽  
Author(s):  
Arvin Haj-Mirzaian ◽  
Hossein Amini-Khoei ◽  
Arya Haj-Mirzaian ◽  
Shayan Amiri ◽  
Maria Ghesmati ◽  
...  
Keyword(s):  
Mouse Model ◽  
Social Isolation ◽  
Cannabinoid Receptors ◽  
Isolation Stress ◽  
Social Isolation Stress

T1677 Changes in Ghrelin or Upper Gastrointestinal-Associated Factor Gene Expression in Mice That Are Under Social Isolation Stress or Restricted Stress

2009 ◽  
Vol 136 (5) ◽  
pp. A-556
Author(s):  
Hiroshi Takeda ◽  
Shuichi Muto ◽  
Takehiko Katsurada ◽  
Yayoi Inagaki ◽  
Kazuaki Tsuchiya ◽  
...  
Keyword(s):  
Gene Expression ◽  
Social Isolation ◽  
Isolation Stress ◽  
Associated Factor ◽  
Factor Gene ◽  
Social Isolation Stress ◽  
Upper Gastrointestinal

Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice

2012 ◽  
Vol 73 (3) ◽  
pp. 257-262 ◽  
Author(s):  
Kinzo Matsumoto ◽  
Kazuya Ono ◽  
Hirofumi Ouchi ◽  
Ryohei Tsushima ◽  
Yukihisa Murakami
Keyword(s):  
Social Isolation ◽  
Growth Response ◽  
Early Growth ◽  
Isolation Stress ◽  
Early Growth Response ◽  
Social Isolation Stress ◽  
Early Growth Response 1

scholarly journals Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-1-25
Author(s):  
Muhammad Imran Khan ◽  
Vahid Nikoui ◽  
Jamal Ahmad ◽  
Bashir Ahmad ◽  
Ahmad-Reza Dehpour
Keyword(s):  
Social Isolation ◽  
Male Mice ◽  
Isolation Stress ◽  
Social Isolation Stress

scholarly journals PPAR-α Hypermethylation in the Hippocampus of Mice Exposed to Social Isolation Stress Is Associated with Enhanced Neuroinflammation and Aggressive Behavior

2021 ◽  
Vol 22 (19) ◽  
pp. 10678
Author(s):  
Francesco Matrisciano ◽  
Graziano Pinna
Keyword(s):  
Social Isolation ◽  
Histone Deacetylases ◽  
Epigenetic Modification ◽  
Emotional Behavior ◽  
Peroxisome Proliferator ◽  
Neuroprotective Effects ◽  
Peroxisome Proliferator Activated Receptor ◽  
Isolation Stress ◽  
Social Isolation Stress ◽  
Socially Isolated

Social behavioral changes, including social isolation or loneliness, increase the risk for stress-related disorders, such as major depressive disorder, posttraumatic stress disorder (PTSD), and suicide, which share a strong neuroinflammatory etiopathogenetic component. The peroxisome-proliferator activated receptor (PPAR)-α, a newly discovered target involved in emotional behavior regulation, is a ligand-activated nuclear receptor and a transcription factor that, following stimulation by endogenous or synthetic ligands, may induce neuroprotective effects by modulating neuroinflammation, and improve anxiety and depression-like behaviors by enhancing neurosteroid biosynthesis. How stress affects epigenetic mechanisms with downstream effects on inflammation and emotional behavior remains poorly understood. We studied the effects of 4-week social isolation, using a mouse model of PTSD/suicide-like behavior, on hippocampal PPAR-α epigenetic modification. Decreased PPAR-α expression in the hippocampus of socially isolated mice was associated with increased levels of methylated cytosines of PPAR-α gene CpG-rich fragments and deficient neurosteroid biosynthesis. This effect was associated with increased histone deacetylases (HDAC)1, methyl-cytosine binding protein (MeCP)2 and decreased ten-eleven translocator (TET)2 expression, which favor hypermethylation. These alterations were associated with increased TLR-4 and pro-inflammatory markers (e.g., TNF-α,), mediated by NF-κB signaling in the hippocampus of aggressive mice. This study contributes the first evidence of stress-induced brain PPAR-α epigenetic regulation. Social isolation stress may constitute a risk factor for inflammatory-based psychiatric disorders associated with neurosteroid deficits, and targeting epigenetic marks linked to PPAR-α downregulation may offer a valid therapeutic approach.

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