scholarly journals β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease

2020 ◽  
Vol 10 ◽  
Author(s):  
Nanbu Wang ◽  
Haoyu Wang ◽  
Lingyu Li ◽  
Yunchuan Li ◽  
Ronghua Zhang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Amyloid Β ◽  
Model Of Alzheimer’S Disease ◽  
A Cell

Mass Spectrometric Characterization of Amyloid-β Species in the 7PA2 Cell Model of Alzheimer's Disease

2012 ◽  
Vol 33 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Erik Portelius ◽  
Maria Olsson ◽  
Gunnar Brinkmalm ◽  
Ulla Rüetschi ◽  
Niklas Mattsson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Amyloid Β ◽  
Mass Spectrometric ◽  
Model Of Alzheimer’S Disease ◽  
7Pa2 Cell

Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer's disease

2021 ◽  
pp. 113577
Author(s):  
Elizaveta A. Dutysheva ◽  
Irina A. Utepova ◽  
Maria A. Trestsova ◽  
Alexander S. Anisimov ◽  
Valery N. Charushin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Model Of Alzheimer’S Disease ◽  
A Cell

Accelerated Aβ Generation in a Cell Model of Alzheimer's Disease-related Endosomal–Lysosomal System Upregulation

2003 ◽  
pp. 461-467
Author(s):  
Paul M. Mathews ◽  
Carolyn B. Guerra ◽  
Ying Jiang ◽  
Benjamin H. Kao ◽  
Ravi Dinakar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Model Of Alzheimer’S Disease ◽  
A Cell ◽  
Lysosomal System ◽  
Aβ Generation

MicroRNA-107 Ameliorates Damage in a Cell Model of Alzheimer’s Disease by Mediating the FGF7/FGFR2/PI3K/Akt Pathway

2020 ◽  
Vol 70 (10) ◽  
pp. 1589-1597 ◽  
Author(s):  
Wei Chen ◽  
Lin Wu ◽  
Yueqiang Hu ◽  
Lingfei Jiang ◽  
Ni Liang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Akt Pathway ◽  
Model Of Alzheimer’S Disease ◽  
A Cell

Neuroprotective Effect of Tetrahedral DNA Nanostructures in a Cell Model of Alzheimer’s Disease

2018 ◽  
Vol 10 (28) ◽  
pp. 23682-23692 ◽  
Author(s):  
Xiaoru Shao ◽  
Wenjuan Ma ◽  
Xueping Xie ◽  
Qianshun Li ◽  
Shiyu Lin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Model ◽  
Neuroprotective Effect ◽  
Dna Nanostructures ◽  
Model Of Alzheimer’S Disease ◽  
A Cell

scholarly journals Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer’s Disease

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1802
Author(s):  
Enrique Armijo ◽  
George Edwards ◽  
Andrea Flores ◽  
Jorge Vera ◽  
Mohammad Shahnawaz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Symptoms ◽  
Memory Loss ◽  
Amyloid Β ◽  
Cerebral Atrophy ◽  
Brain Inflammation ◽  
Neural Precursors ◽  
Model Of Alzheimer’S Disease ◽  
Induced Pluripotent

Alzheimer’s disease (AD) is the most common type of dementia in the elderly population. The disease is characterized by progressive memory loss, cerebral atrophy, extensive neuronal loss, synaptic alterations, brain inflammation, extracellular accumulation of amyloid-β (Aβ) plaques, and intracellular accumulation of hyper-phosphorylated tau (p-tau) protein. Many recent clinical trials have failed to show therapeutic benefit, likely because at the time in which patients exhibit clinical symptoms the brain is irreversibly damaged. In recent years, induced pluripotent stem cells (iPSCs) have been suggested as a promising cell therapy to recover brain functionality in neurodegenerative diseases such as AD. To evaluate the potential benefits of iPSCs on AD progression, we stereotaxically injected mouse iPSC-derived neural precursors (iPSC-NPCs) into the hippocampus of aged triple transgenic (3xTg-AD) mice harboring extensive pathological abnormalities typical of AD. Interestingly, iPSC-NPCs transplanted mice showed improved memory, synaptic plasticity, and reduced AD brain pathology, including a reduction of amyloid and tangles deposits. Our findings suggest that iPSC-NPCs might be a useful therapy that could produce benefit at the advanced clinical and pathological stages of AD.

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