scholarly journals Network Meta-Analysis of Calcitonin Gene-Related Peptide Receptor Antagonists for the Acute Treatment of Migraine

2019 ◽  
Vol 10 ◽  
Author(s):  
Fang Xu ◽  
Wenjun Sun
Keyword(s):  
Acute Treatment ◽  
Meta Analysis ◽  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Effect of Calcitonin Gene-Related Peptide Receptor Antagonists on Migraine Treatment: A Meta-Analysis

2021 ◽  
Author(s):  
Jiyoung Kim ◽  
Kyoungjune Pak ◽  
Gha-Hyun Lee ◽  
Jae Wook Cho ◽  
Hyun-Woo kim
Keyword(s):  
Meta Analysis ◽  
Calcitonin Gene Related Peptide ◽  
Migraine Treatment ◽  
Acute Migraine ◽  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cgrp Receptor Antagonists ◽  
Acute Migraine Treatment

Abstract Background: The pathophysiology of migraine has been researched incessantly, and it has been suggested that calcitonin gene-related peptide (CGRP) is associated with migraine attacks. CGRP receptor blockers are attracting attention for migraine prevention and treatment of acute episodes, and CGRP receptor antagonists have been shown to be effective in treating acute migraine headaches. This meta-analysis aimed to assess the effect of available CGRP receptor antagonists, focusing on their therapeutic doses for acute migraine treatment.Methods: We performed a systematic search of MEDLINE (from inception to March 2021) and EMBASE (from inception to March 2021) for English publications using the keywords “migraine” and “Calcitonin gene-related peptide,” limited to human studies.Results: Five studies that focused on examining the effects of CGRP receptor antagonists on acute migraine treatment met the eligibility criteria for this meta-analysis. The pooled analysis demonstrated that the CGRP receptor antagonist improved freedom from pain (OR=2.066, 95% confidence interval [CI] 1.766–2.418, I2=0%), absence of bothersome symptoms (OR=1.606, 95% CI=1.408–1.830, I2=0%), pain relief (OR=1.791, 95% CI=1.598–2.008, I2=0%), and freedom from nausea (OR=1.361, 95% CI=1.196–1.548, I2=0%), significantly more than the placebo. Conclusions: CGRP receptor antagonists are effective for acute migraine treatment and are expected to be used clinically as emerging therapeutic agents.

Discovery of potent, cyclic calcitonin gene-related peptide receptor antagonists

2011 ◽  
Vol 17 (5) ◽  
pp. 383-386 ◽  
Author(s):  
Liang Zeng Yan ◽  
Kirk W. Johnson ◽  
Emily Rothstein ◽  
David Flora ◽  
Patrick Edwards ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice

2020 ◽  
Vol 88 (4) ◽  
pp. 771-784 ◽  
Author(s):  
Inge A. Mulder ◽  
Mei Li ◽  
Tessa Vries ◽  
Tao Qin ◽  
Takeshi Yanagisawa ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cerebral Ischemic

Discovery techniques for calcitonin gene-related peptide receptor antagonists for potential antimigraine therapies

2013 ◽  
Vol 8 (11) ◽  
pp. 1309-1323 ◽  
Author(s):  
Sieneke Labruijere ◽  
Khatera Ibrahimi ◽  
Kayi Y Chan ◽  
Antoinette MaassenVanDenBrink
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene
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