scholarly journals Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning

2019 ◽  
Vol 10 ◽  
Author(s):  
Timothy B. C. Johnstone ◽  
Hilary S. McCarren ◽  
Jay Spampanato ◽  
F. Edward Dudek ◽  
John H. McDonough ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

scholarly journals LDH LEVEL IN ACUTE ORGANOPHOSPHORUS POISONING AND ITS RELATION WITH SEVERITY AND MORTALITY: A TERTIARY CARE HOSPITAL EXPERIENCE

2021 ◽  
Vol 5 (4) ◽  
Author(s):  
Suresh Kumar Nagar ◽  
Maniram Kumhar ◽  
V. B. Singh ◽  
Mayank Srivastav
Keyword(s):  
Organophosphorus Compounds ◽  
Tertiary Care ◽  
Crop Protection ◽  
Serum Lactate ◽  
Spectrophotometric Analysis ◽  
Serum Lactate Dehydrogenase ◽  
Care Hospital ◽  
Significant Difference ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

Background: Organophosphorus compounds have been widely used for a few decades in agriculture for crop protection and pest control. In India Organophosphorus poisoning is the most common. The objective of our study was to measure the  LDH Level in acute organophosphorus poisoning Methods: This study was conducted among minimum 100 patients acute organophosphorus poisoning admitted in Casualty ward, MICU and attending medical ward of JLN hospital, Ajmer during Aug 2018 to July 2020. Serum lactate dehydrogenase estimation by spectrophotometric analysis using Beckman Coalter AU 680 Results: These were significantly higher among deaths on day 1 and 3(810±372.99 and 1027.09±458.26, respectively) in comparison to survivors on day 1 and 3 (538.18±300.42 and 365.19±175.49, respectively). Significant difference was found between mean values of different levels of severity of LDH on day 1 and 3. Conclusion: In conclusion, this study found that Serum LDH can be used as biomarker in diagnosis or stratifying severity of acute OP poisoning, as it is cheap and easily available, especially in developing countries. Serial measurements of serum LDH levels in acute OP poisoning can predict the prognosis. Keywords: LDH, OP poisoning, Severity

Clinical benefits of magnesium sulfate in management of acute organophosphorus poisoning

2018 ◽  
Vol 1 (2) ◽  
pp. 30 ◽  
Author(s):  
SamahF Ibrahim ◽  
UsamaM Elbarrany ◽  
MohammedA Mohamed ◽  
HishamA Elshekheby ◽  
TarekAS Afify
Keyword(s):  
Magnesium Sulfate ◽  
Organophosphorus Poisoning ◽  
Clinical Benefits ◽  
Acute Organophosphorus Poisoning

Dysfunction in macula, retinal pigment epithelium and post retinal pathway in acute organophosphorus poisoning

2020 ◽  
pp. 1-7
Author(s):  
Padmini Dahanayake ◽  
Tharaka L. Dassanayake ◽  
Manoji Pathirage ◽  
Anuradha Colombage ◽  
Indika B. Gawarammana ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

scholarly journals Multiomic Analysis of Zebrafish Models of Acute Organophosphorus Poisoning With Different Severity

2019 ◽  
Vol 171 (1) ◽  
pp. 211-220
Author(s):  
Benjamin Piña ◽  
Tamar Ziv ◽  
Melissa Faria ◽  
Shani Ben-Lulu ◽  
Eva Prats ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Organophosphorus Compounds ◽  
Cholinergic Neurons ◽  
Acetylcholinesterase Inhibitors ◽  
Chemical Models ◽  
Organophosphorus Poisoning ◽  
Important Therapeutic Target ◽  
Acute Organophosphorus Poisoning ◽  
Integrative Omics

Abstract Organophosphorus compounds are acetylcholinesterase inhibitors used as pesticides and chemical warfare nerve agents. Acute organophosphorus poisoning (acute OPP) affects 3 million people, with 300 000 deaths annually worldwide. Severe acute OPP effects include overstimulation of cholinergic neurons, seizures, status epilepticus, and finally, brain damage. In a previous study, we developed 3 different chemical models of acute OPP in zebrafish larvae. To elucidate the complex pathophysiological pathways related to acute OPP, we used integrative omics (proteomic, transcriptomics, and metabolomics) on these 3 animal models. Our results show that these stochastic, apparently disparate morphological phenotypes can result from almost linear concentration-response variations in molecular levels. Results from the multiomics analysis strongly suggest that endoplasmic reticulum stress might play a central role in the pathophysiology of severe acute OPP, emphasizing the urgent need of further research on this molecular pathway. Endoplasmic reticulum stress could be an important therapeutic target to be included in the treatment of patients with severe acute OPP.

Hemorrhagic panesophagitis after acute organophosphorus poisoning

1999 ◽  
Vol 49 (5) ◽  
pp. 642-643 ◽  
Author(s):  
Hideki Koga ◽  
Mayumi Yoshinaga ◽  
Kunihiko Aoyagi ◽  
Hiroshi Yagi ◽  
Mitsuo Iida ◽  
...  
Keyword(s):  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

Meta analysis of atropine in treatment of acute organophosphorus poisoning

2011 ◽  
Vol 11 (6) ◽  
pp. 456-458
Author(s):  
HuaLin ZHANG ◽  
LiSha ZHANG ◽  
Jin HUANG ◽  
JinHong HU
Keyword(s):  
Meta Analysis ◽  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning

Acute organophosphorus poisoning in humans: A PK model for chlorpyrifos

2012 ◽  
Vol 211 ◽  
pp. S173
Author(s):  
Jacqueline M. Anderson ◽  
Klas J. Petersson ◽  
Lena E. Friberg ◽  
Franz Worek ◽  
Horst Thiermann ◽  
...  
Keyword(s):  
Organophosphorus Poisoning ◽  
Acute Organophosphorus Poisoning
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