scholarly journals Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam as CYP3A Probe Drug in a Porcine Animal Model: A Pilot Study

2019 ◽  
Vol 10 ◽  
Author(s):  
Wim Schelstraete ◽  
Mathias Devreese ◽  
Siska Croubels
Keyword(s):  
Animal Model ◽  
Pilot Study ◽  
Probe Drug ◽  
Subacute Exposure

An animal model for the study of Chamomilla in stress and depression: pilot study

Homeopathy ◽  
2008 ◽  
Vol 97 (3) ◽  
pp. 141-144 ◽  
Author(s):  
Sandra Augusta Gordinho Pinto ◽  
Elisabeth Bohland ◽  
Cideli de Paula Coelho ◽  
Maria Sílvia Furquim de Azevedo Morgulis ◽  
Leoni Villano Bonamin
Keyword(s):  
Animal Model ◽  
Pilot Study

Experimental Animal Model of Subglottic Stenosis

1977 ◽  
Vol 86 (6) ◽  
pp. 835-840 ◽  
Author(s):  
Bernard Borowiecki ◽  
Charles B. Croft
Keyword(s):  
Animal Model ◽  
Pilot Study ◽  
Experimental Animal ◽  
Cricoid Cartilage ◽  
Subglottic Stenosis ◽  
Experimental Animal Model ◽  
Show Evidence

An animal model of subglottic stenosis has been developed. The results of this pilot study show evidence to suggest that injury to the cricoid cartilage leading to perichondritis is the important factor in the development of subglottic stenosis.

scholarly journals Oxidative Stress Aggravates Apoptosis of Nucleus Pulposus Cells through m6A Modification of MAT2A Pre-mRNA by METTL16

2022 ◽  
Vol 2022 ◽  
pp. 1-15
Author(s):  
Peng-Bo Chen ◽  
Gui-Xun Shi ◽  
Tao Liu ◽  
Bo Li ◽  
Sheng-Dan Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Model ◽  
Pilot Study ◽  
Nucleus Pulposus ◽  
Intervertebral Disc Degeneration ◽  
Nucleus Pulposus Cell ◽  
Nucleus Pulposus Cells ◽  
Human Npcs

The process of intervertebral disc degeneration (IVDD) is complex, and its mechanism is considered multifactorial. Apoptosis of oxidative stressed nucleus pulposus cells (NPCs) should be a fundamental element in the pathogenesis of IVDD. In our pilot study, we found that the expression of MAT2A decreased, and METTL16 increased in the degenerative nucleus pulposus tissues. Previous studies have shown that the balance of splicing, maturation, and degradation of MAT2A pre-mRNA is regulated by METTL16 m6A modification. In the current study, we aimed to figure out whether this mechanism was involved in the aberrant apoptosis of NPCs and IVDD. Human NPCs were isolated and cultured under oxidative stress. An IVDD animal model was established. It showed that significantly higher METTL16 expression and lower MAT2A expression were seen in either the NPCs under oxidative stress or the degenerative discs of the animal model. MAT2A was inhibited with siRNA in vitro or cycloleucine in vivo. METTL16 was overexpressed with lentivirus in vitro or in vivo. Downregulation of MAT2A or upregulation of METTL16 aggravated nucleus pulposus cell apoptosis and disc disorganization. The balance of splicing, maturation, and degradation of MAT2A pre-mRNA was significantly inclined to degradation in the NPCs with the overexpression of METTL16. Increased apoptosis of NPCs under oxidative stress could be rescued by reducing the expression of METTL16 using siRNA with more maturation of MAT2A pre-mRNA. Collectively, oxidative stress aggravates apoptosis of NPCs through disrupting the balance of splicing, maturation, and degradation of MAT2A pre-mRNA, which is m6A modified by METTL16.

scholarly journals Phenotypic Characteristics Shared by Preeclamptic Patients and an Animal Model of the Syndrome: Report of a Pilot Study

2006 ◽  
Vol 19 (9) ◽  
pp. 947-950 ◽  
Author(s):  
A ALPER ◽  
J OUTLAND ◽  
K FINIGAN ◽  
G PRIDJIAN ◽  
A AINAMUMUNEY ◽  
...  
Keyword(s):  
Animal Model ◽  
Pilot Study ◽  
Phenotypic Characteristics ◽  
Syndrome Report

scholarly journals Heterotopic Bone Formation Around Vessels: Pilot Study of a New Animal Model

2013 ◽  
Vol 2 (4) ◽  
pp. 266-272 ◽  
Author(s):  
Wei-Xin Cai ◽  
Li-Wu Zheng ◽  
Franz E. Weber ◽  
Chun-Lei Li ◽  
Li Ma ◽  
...  
Keyword(s):  
Animal Model ◽  
Pilot Study ◽  
Bone Formation ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation
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