scholarly journals Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation

2019 ◽  
Vol 9 ◽  
Author(s):  
Victor Samokhvalov ◽  
K. Lockhart Jamieson ◽  
Ahmed M. Darwesh ◽  
Hedieh Keshavarz-Bahaghighat ◽  
Tim Y. T. Lee ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Epoxide Hydrolase ◽  
Acute Inflammation ◽  
Soluble Epoxide Hydrolase

scholarly journals Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice

2013 ◽  
Vol 104-105 ◽  
pp. 8-17 ◽  
Author(s):  
Ketul R. Chaudhary ◽  
Beshay N.M. Zordoky ◽  
Matthew L. Edin ◽  
Nasser Alsaleh ◽  
Ayman O.S. El-Kadi ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Differential Effects ◽  
Aged Mice

scholarly journals Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury

2021 ◽  
Vol 22 (4) ◽  
pp. 1691
Author(s):  
K. Lockhart Jamieson ◽  
Ahmed M. Darwesh ◽  
Deanna K. Sosnowski ◽  
Hao Zhang ◽  
Saumya Shah ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Epoxide Hydrolase ◽  
Significant Proportion ◽  
Ischemic Injury ◽  
Soluble Epoxide Hydrolase ◽  
Mitochondrial Activity ◽  
Metabolite Formation ◽  
Female Mice ◽  
Enzymatic Function

Myocardial infarction (MI) accounts for a significant proportion of death and morbidity in aged individuals. The risk for MI in females increases as they enter the peri-menopausal period, generally occurring in middle-age. Cytochrome (CYP) 450 metabolizes N-3 and N-6 polyunsaturated fatty acids (PUFA) into numerous lipid mediators, oxylipids, which are further metabolised by soluble epoxide hydrolase (sEH), reducing their activity. The objective of this study was to characterize oxylipid metabolism in the left ventricle (LV) following ischemic injury in females. Human LV specimens were procured from female patients with ischemic cardiomyopathy (ICM) or non-failing controls (NFC). Female C57BL6 (WT) and sEH null mice averaging 13–16 months old underwent permanent occlusion of the left anterior descending coronary artery (LAD) to induce myocardial infarction. WT (wild type) mice received vehicle or sEH inhibitor, trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (tAUCB), in their drinking water ad libitum for 28 days. Cardiac function was assessed using echocardiography and electrocardiogram. Protein expression was determined using immunoblotting, mitochondrial activity by spectrophotometry, and cardiac fibre respiration was measured using a Clark-type electrode. A full metabolite profile was determined by LC–MS/MS. sEH was significantly elevated in ischemic LV specimens from patients, associated with fundamental changes in oxylipid metabolite formation and significant decreases in mitochondrial enzymatic function. In mice, pre-treatment with tAUCB or genetic deletion of sEH significantly improved survival, preserved cardiac function, and maintained mitochondrial quality following MI in female mice. These data indicate that sEH may be a relevant pharmacologic target for women with MI. Although future studies are needed to determine the mechanisms, in this pilot study we suggest targeting sEH may be an effective strategy for reducing ischemic injury and mortality in middle-aged females.

scholarly journals GENETIC DELETION OF SOLUBLE EPOXIDE HYDROLASE PRESERVES CARDIAC FUNCTION IN AGED FEMALE MICE

2019 ◽  
Vol 35 (10) ◽  
pp. S12
Author(s):  
H. Keshavarz-Bahaghighat ◽  
K. Jamieson ◽  
A. Darwesh ◽  
J. Seubert
Keyword(s):  
Cardiac Function ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Female Mice ◽  
Genetic Deletion

scholarly journals Genetic deletion of soluble epoxide hydrolase preserves cardiac function and limits inflammation in acute lipopolysaccharide injury

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Deanna Sosnowski ◽  
K. Jamieson ◽  
Ahmed Darwesh ◽  
Artiom Gruzdev ◽  
Darryl Zeldin ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Genetic Deletion

scholarly journals Soluble epoxide hydrolase is a therapeutic target for acute inflammation

2005 ◽  
Vol 102 (28) ◽  
pp. 9772-9777 ◽  
Author(s):  
K. R. Schmelzer ◽  
L. Kubala ◽  
J. W. Newman ◽  
I.-H. Kim ◽  
J. P. Eiserich ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Epoxide Hydrolase ◽  
Acute Inflammation ◽  
Soluble Epoxide Hydrolase
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