scholarly journals 17β-Estradiol Enhances Schwann Cell Differentiation via the ERβ-ERK1/2 Signaling Pathway and Promotes Remyelination in Injured Sciatic Nerves

2018 ◽  
Vol 9 ◽  
Author(s):  
Yun Gu ◽  
Yumen Wu ◽  
Wenfeng Su ◽  
LingYan Xing ◽  
Yuntian Shen ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Schwann Cell ◽  
Signaling Pathway ◽  
17Β Estradiol ◽  
Sciatic Nerves ◽  
Schwann Cell Differentiation

scholarly journals Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2141
Author(s):  
Kyuhee Park ◽  
Yoonkyoung Shin ◽  
Gyeongbeen Lee ◽  
Hwantae Park ◽  
Yongmun Choi
Keyword(s):  
Cell Differentiation ◽  
Schwann Cell ◽  
Signaling Pathway ◽  
Small Molecule ◽  
Molecular Mechanisms ◽  
Erk Signaling ◽  
Akt Phosphorylation ◽  
Pharmacological Inhibition ◽  
Schwann Cell Differentiation

Schwann cell differentiation involves a dynamic interaction of signaling cascades. However, much remains to be elucidated regarding the function of signaling molecules that differ depending on the context in which the molecules are engaged. Here, we identified a small molecule, dabrafenib, which promotes Schwann cell differentiation in vitro and exploited this compound as a pharmacological tool to understand the molecular mechanisms regulating Schwann cell differentiation. The results indicated that dabrafenib inhibited ERK phosphorylation and enhanced ErbB2 autophosphorylation and Akt phosphorylation, and the effects of dabrafenib on ErbB2 and Akt phosphorylation were phenocopied by pharmacological inhibition of the MEK-ERK signaling pathway. However, the small molecule inhibitors of MEK and ERK had no effect on the expression of Oct6 and EGR2, which are key transcription factors that drive Schwann cell differentiation. In addition, pharmacological inhibition of phosphatidylinositol-3-kinase (PI3K) almost completely interfered with dabrafenib-induced Schwann cell differentiation. These results suggest that the ErbB2-PI3K-Akt axis is required for the induction of Schwann cell differentiation by dabrafenib in vitro. Although additional molecules targeted by dabrafenib remain to be identified, our data provides insights into the crosstalk that exists between the MEK-ERK signaling pathway and the PI3K-Akt axis in Schwann cell differentiation.

scholarly journals Phosphorylation of eIF2α Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR

2020 ◽  
Vol 40 (42) ◽  
pp. 8174-8187
Author(s):  
Cristina Scapin ◽  
Cinzia Ferri ◽  
Emanuela Pettinato ◽  
Francesca Bianchi ◽  
Ubaldo Del Carro ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Schwann Cell ◽  
Schwann Cell Differentiation

The Transcription Factors SCIP and Krox-20 Mark Distinct Stages and Cell Fates in Schwann Cell Differentiation

1996 ◽  
Vol 8 (2-3) ◽  
pp. 129-145 ◽  
Author(s):  
Todd S. Zorick ◽  
Daniel E. Syroid ◽  
Edgardo Arroyo ◽  
Steven S. Scherer ◽  
Greg Lemke
Keyword(s):  
Transcription Factors ◽  
Cell Differentiation ◽  
Schwann Cell ◽  
Cell Fates ◽  
Schwann Cell Differentiation

scholarly journals Expression of Laminin Receptors in Schwann Cell Differentiation: Evidence for Distinct Roles

2003 ◽  
Vol 23 (13) ◽  
pp. 5520-5530 ◽  
Author(s):  
Stefano C. Previtali ◽  
Alessandro Nodari ◽  
Carla Taveggia ◽  
Celia Pardini ◽  
Giorgia Dina ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Schwann Cell ◽  
Laminin Receptors ◽  
Schwann Cell Differentiation

scholarly journals Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation

Science ◽  
2009 ◽  
Vol 323 (5914) ◽  
pp. 651-654 ◽  
Author(s):  
S.-C. Kao ◽  
H. Wu ◽  
J. Xie ◽  
C.-P. Chang ◽  
J. A. Ranish ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Schwann Cell ◽  
Schwann Cell Differentiation
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