scholarly journals Association Between Cholangiocarcinoma and Proton Pump Inhibitors Use: A Nested Case-Control Study

2018 ◽  
Vol 9 ◽  
Author(s):  
Yen-Chun Peng ◽  
Cheng-Li Lin ◽  
Wan-Yun Hsu ◽  
Wai-Keung Chow ◽  
Show-Wu Lee ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041543
Author(s):  
Keiko Ikuta ◽  
Shunsaku Nakagawa ◽  
Kenji Momo ◽  
Atsushi Yonezawa ◽  
Kotaro Itohara ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Renal Diseases ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

ObjectivesThis study aimed to assess whether the combined use of proton pump inhibitors (PPIs) with non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics (penicillins, macrolides, cephalosporins or fluoroquinolones) was associated with an increased risk of acute kidney injury (AKI).DesignA nested case–control study.SettingA health insurance claims database constructed by the Japan Medical Data Center.ParticipantsPatients were eligible if they were prescribed a PPI, NSAID and antibiotic at least once between January 2005 and June 2017. The patients who were new PPI users and did not have any history of renal diseases before cohort entry were included (n=219 082). The mean age was 45 and 44% were women.InterventionsCurrent use of PPIs, NSAIDs, or antibiotics.Primary outcome measuresAcute kidney injury.ResultsDuring a mean follow-up of 2.4 (SD, 1.7) years, 317 cases of AKI were identified (incidence rate of 6.1/10 000 person-years). The current use of PPIs was associated with a higher risk of AKI compared with past PPI use (unadjusted OR, 4.09; 95% CI, 3.09 to 5.44). The unadjusted ORs of AKI for the current use of PPIs with NSAIDs, cephalosporins and fluoroquinolones, compared with the current use of PPIs alone, were 3.92 (95% CI, 2.40 to 6.52), 2.57 (1.43 to 4.62) and 3.08 (1.50 to 6.38), respectively. The effects of concurrent use of PPIs with NSAIDs, cephalosporins or fluoroquinolones remain significant in the adjusted model. The analyses on absolute risk of AKI confirmed the results from the nested case–control study.ConclusionsConcomitant use of NSAIDs with PPIs significantly increased the risk for AKI. Moreover, the results suggested that concomitant use of cephalosporins or fluoroquinolones with PPIs was associated with increased risk of incident AKI.

scholarly journals Out-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control Study

2013 ◽  
Vol 62 (4) ◽  
pp. 730-737 ◽  
Author(s):  
Ioannis Koulouridis ◽  
Mansour Alfayez ◽  
Hocine Tighiouart ◽  
Nicolaos E. Madias ◽  
David M. Kent ◽  
...  
Keyword(s):  
Hospital Admission ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study ◽  
Hospital Use

scholarly journals GI2 DICLOFENAC-ASSOCIATED ULCER RISK IS REDUCED BY PROTON PUMP INHIBITORS: NESTED CASE CONTROL STUDY

2006 ◽  
Vol 9 (6) ◽  
pp. A190
Author(s):  
A Höer ◽  
H Gothe ◽  
S Mangiapane ◽  
A Sterzel ◽  
U Grass ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Proton pump inhibitors are associated with increased risk of alopecia areata: A nationwide nested case-control study

2020 ◽  
Vol 83 (5) ◽  
pp. 1460-1462
Author(s):  
Cheng-Yuan Li ◽  
Ying-Xiu Dai ◽  
Yun-Ting Chang ◽  
Ya-Mei Bai ◽  
Shih-Jen Tsai ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Alopecia Areata ◽  
Case Control Study ◽  
Case Control ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

scholarly journals Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Proton Pump Inhibitors, or Metoclopramide: A Population-Based Nested Case-Control Study

Drug Safety ◽  
2015 ◽  
Vol 38 (12) ◽  
pp. 1187-1199 ◽  
Author(s):  
Alejandro Arana ◽  
Catherine B. Johannes ◽  
Lisa J. McQuay ◽  
Cristina Varas-Lorenzo ◽  
Daniel Fife ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Cardiac Death ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study
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