scholarly journals Who Is Who in Adenosine Transport

2018 ◽  
Vol 9 ◽  
Author(s):  
Marçal Pastor-Anglada ◽  
Sandra Pérez-Torras
Keyword(s):  
Adenosine Transport

Inhibition of Na transport by 2-chloroadenosine: dissociation from production of cyclic nucleotides

1990 ◽  
Vol 68 (10) ◽  
pp. 1357-1362
Author(s):  
Russell F. Husted ◽  
Gerard P. Clancy ◽  
Abigail Adams-Brotherton ◽  
John B. Stokes
Keyword(s):  
Adenosine Receptors ◽  
Cyclic Nucleotides ◽  
Cell Function ◽  
Apical Membrane ◽  
Second Messengers ◽  
Basolateral Membrane ◽  
Primary Cultures ◽  
Good Evidence ◽  
Camp Content ◽  
Adenosine Transport

The adenosine analogue 2-chloroadenosine (2-CA) is often used to determine the biologic effects of adenosine because 2-CA is less susceptible to degradation than adenosine. We studied the effects of 2-CA on primary cultures of rat inner medullary collecting ducts because there is good evidence that adenosine can influence cell function through its effects on second messengers. 2-CA inhibited Na+ transport across the apical membrane and increased cAMP content of the cells. The major adenosine receptors in these cells appear to be the stimulatory (A2) type. Stimulation of cAMP by 2-CA was more potent when applied to the apical membrane than to the basolateral membrane, an effect opposite to that of vasopressin. These results imply that adenosine receptors are more numerous or more effective on the apical membrane than on the basolateral membrane. Inhibition of Na+ transport was probably not mediated by an adenosine receptor as evidenced by (i) a lack of effect of adenosine and other adenosine analogues on Na+ transport; (ii) a lack of effect of nonmetabolizable cyclic nucleotides on Na+ transport; and (iii) a clear discrepancy in the temporal course of 2-CA effects on a second messenger system (cAMP) and 2-CA inhibition of Na+ transport. Dipyridimole, an inhibitor of adenosine transport, also reduced Na+ transport. Taken together, the data suggest that 2-CA inhibits Na+ transport by interfering with adenosine transport or metabolism.Key words: cAMP, cGMP, 2-chloroadenosine, vasopressin, Na+ transport, dipyridimole, adenosine metabolism.

Functional characterization of adenosine transport across the BBB in mice

2005 ◽  
Vol 290 (1-2) ◽  
pp. 37-44 ◽  
Author(s):  
Hideyasu Murakami ◽  
Airi Ohkura ◽  
Hitomi Takanaga ◽  
Hirotami Matsuo ◽  
Noriko Koyabu ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Adenosine Transport

Erythrocyte adenosine transport a rapid screening test for cardiovascular drugs

1993 ◽  
Vol 30 (3) ◽  
pp. 163-167 ◽  
Author(s):  
Pollen K.F. Yeung ◽  
Susan J. Mosher ◽  
Rongshi Li ◽  
Patrick S. Farmer ◽  
Gerald A. Klassen ◽  
...  
Keyword(s):  
Screening Test ◽  
Cardiovascular Drugs ◽  
Rapid Screening ◽  
Rapid Screening Test ◽  
Adenosine Transport

Is adenosine deaminase involved in adenosine transport?

1990 ◽  
Vol 33 (4) ◽  
pp. 245-250 ◽  
Author(s):  
J.J Centelles ◽  
R Franco
Keyword(s):  
Adenosine Deaminase ◽  
Adenosine Transport
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