scholarly journals pH Responsive Polymer Micelles Enhances Inhibitory Efficacy on Metastasis of Murine Breast Cancer Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Jie Wang ◽  
Gejing De ◽  
Qiaoxin Yue ◽  
Hai Ma ◽  
Jintang Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Ph Responsive ◽  
Polymer Micelles ◽  
Responsive Polymer

scholarly journals Targeting triple-negative breast cancer cells using Dengue virus-mimicking pH-responsive framboidal triblock copolymer vesicles

2019 ◽  
Vol 10 (18) ◽  
pp. 4811-4821 ◽  
Author(s):  
Charlotte J. Mable ◽  
Irene Canton ◽  
Oleksandr O. Mykhaylyk ◽  
Burcin Ustbas Gul ◽  
Pierre Chambon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nucleic Acid ◽  
Dengue Virus ◽  
Cancer Cells ◽  
Dengue Fever ◽  
Triple Negative Breast Cancer ◽  
Triblock Copolymer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Ph Responsive

Dengue fever-mimicking pH-responsive framboidal triblock copolymer vesicles enable delivery of a nucleic acid payload to the nuclei of triple-negative breast cancer cells.

scholarly journals Characterization and Evaluation of Bone-Derived Nanoparticles as a Novel pH-Responsive Carrier for Delivery of Doxorubicin into Breast Cancer Cells

2020 ◽  
Vol 21 (18) ◽  
pp. 6721
Author(s):  
Sheikh Tanzina Haque ◽  
Rowshan Ara Islam ◽  
Siew Hua Gan ◽  
Ezharul Hoque Chowdhury
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Calcium Phosphates ◽  
Protein Corona ◽  
Transport Proteins ◽  
Treatment Modalities ◽  
Carbonate Apatite ◽  
Cellular Internalization ◽  
Ph Responsive

Background: The limitations of conventional treatment modalities in cancer, especially in breast cancer, facilitated the necessity for developing a safer drug delivery system (DDS). Inorganic nano-carriers based on calcium phosphates such as hydroxyapatite (HA) and carbonate apatite (CA) have gained attention due to their biocompatibility, reduced toxicity, and improved therapeutic efficacy. Methods: In this study, the potential of goose bone ash (GBA), a natural derivative of HA or CA, was exploited as a pH-responsive carrier to successfully deliver doxorubicin (DOX), an anthracycline drug into breast cancer cells (e.g., MCF-7 and MDA-MB-231 cells). GBA in either pristine form or in suspension was characterized in terms of size, morphology, functional groups, cellular internalization, cytotoxicity, pH-responsive drug (DOX) release, and protein corona analysis. Results: The pH-responsive drug release study demonstrated the prompt release of DOX from GBA through its disintegration in acidic pH (5.5–6.5), which mimics the pH of the endosomal and lysosomal compartments as well as the stability of GBA in physiological pH (pH 7.5). The result of DOX binding with GBA indicated an increment in binding affinity with increasing concentrations of DOX. Cell viability and cytotoxicity analysis showed no innate toxicity of GBA particles. Both qualitative and quantitative cellular uptake analysis in both cell lines displayed an enhanced cellular internalization of DOX-loaded GBA compared to free DOX molecules. The protein corona spontaneously formed on the surface of GBA particles exhibited its affinity toward transport proteins, structural proteins, and a few other selective proteins. The adsorption of transport proteins could extend the circulation half-life in biological environment and increase the accumulation of the drug-loaded NPs through the enhanced permeability and retention (EPR) effect at the tumor site. Conclusion: These findings highlight the potential of GBA as a DDS to successfully deliver therapeutics into breast cancer cells.

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