scholarly journals Ophiopogonin D′, a Natural Product From Radix Ophiopogonis, Induces in Vitro and in Vivo RIPK1-Dependent and Caspase-Independent Apoptotic Death in Androgen-Independent Human Prostate Cancer Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Zongliang Lu ◽  
He Wang ◽  
Mingxing Zhu ◽  
Wei Song ◽  
Jiajia Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Natural Product ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Apoptotic Death ◽  
Androgen Independent

scholarly journals MicroRNA Let-7a Inhibits Proliferation of Human Prostate Cancer Cells In Vitro and In Vivo by Targeting E2F2 and CCND2

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10147 ◽  
Author(s):  
Qingchuan Dong ◽  
Ping Meng ◽  
Tao Wang ◽  
Weiwei Qin ◽  
Weijun Qin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

In vivo and in vitro studies of anticancer actions of α-TEA for human prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (8) ◽  
pp. 849-860 ◽  
Author(s):  
Li Jia ◽  
Weiping Yu ◽  
Pei Wang ◽  
Bob G. Sanders ◽  
Kimberly Kline
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
In Vitro Studies ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo

2008 ◽  
Vol 29 (10) ◽  
pp. 2001-2010 ◽  
Author(s):  
T. T.Y. Wang ◽  
T. S. Hudson ◽  
T.-C. Wang ◽  
C. M. Remsberg ◽  
N. M. Davies ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Differential Effects

Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo

2010 ◽  
Vol 399 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Toyokazu Sasaki ◽  
Koh-ichi Nakashiro ◽  
Hiroshi Tanaka ◽  
Koji Azuma ◽  
Hiroyuki Goda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Rna Silencing ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Akt Isoforms

scholarly journals Exploring the MIR143-UPAR Axis for the Inhibition of Human Prostate Cancer Cells In Vitro and In Vivo

2019 ◽  
Vol 16 ◽  
pp. 272-283 ◽  
Author(s):  
Sven Wach ◽  
Madeleine Brandl ◽  
Hannes Borchardt ◽  
Katrin Weigelt ◽  
Sabine Lukat ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo

2010 ◽  
Vol 17 (2) ◽  
pp. 481-493 ◽  
Author(s):  
Lei Gu ◽  
Paraskevi Vogiatzi ◽  
Martin Puhr ◽  
Ayush Dagvadorj ◽  
Jacqueline Lutz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Endothelial Cells ◽  
Cancer Cells ◽  
Human Prostate ◽  
Migration And Invasion ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Metastatic Behavior

There are no effective therapies for disseminated prostate cancer. Constitutive activation of Stat5 in prostate cancer is associated with cancer lesions of high histological grade. We have shown that Stat5 is activated in 61% of distant metastases of clinical prostate cancer. Active Stat5 increased metastases formation of prostate cancer cells in nude mice by 11-fold in an experimental metastases assay. Active Stat5 promoted migration and invasion of prostate cancer cells, and induced rearrangement of the microtubule network. Active Stat5 expression was associated with decreased cell surface E-cadherin levels, while heterotypic adhesion of prostate cancer cells to endothelial cells was stimulated by active Stat5. Activation of Stat5 and Stat5-induced binding of prostate cancer cells to endothelial cells were decreased by inhibition of Src but not of Jak2. Gene expression profiling indicated that 21% of Stat5-regulated genes in prostate cancer cells were related to metastases, while 7.9% were related to proliferation and 3.9% to apoptosis. The work presented here provides the first evidence of Stat5 involvement in the induction of metastatic behavior of human prostate cancer cells in vitro and in vivo. Stat5 may provide a therapeutic target protein for disseminated prostate cancer.

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