scholarly journals Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice

2017 ◽  
Vol 8 ◽  
Author(s):  
Eva J. Wunschel ◽  
Bastian Schirmer ◽  
Roland Seifert ◽  
Detlef Neumann
Keyword(s):  
Receptor Expression ◽  
Acute Colitis ◽  
Histamine H4 Receptor ◽  
H4 Receptor

scholarly journals Histamine H4 Receptor Expression in Human Synovial Cells Obtained from Patients Suffering from Rheumatoid Arthritis

2005 ◽  
Vol 28 (10) ◽  
pp. 2016-2018 ◽  
Author(s):  
Yoshiko Ikawa ◽  
Masahiko Suzuki ◽  
Satoshi Shiono ◽  
Emi Ohki ◽  
Hideshige Moriya ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Receptor Expression ◽  
Synovial Cells ◽  
Histamine H4 Receptor ◽  
H4 Receptor

scholarly journals Comparative study of histamine H4 receptor expression in human dermal fibroblasts

2008 ◽  
Vol 33 (4) ◽  
pp. 503-508 ◽  
Author(s):  
Yoshiko Ikawa ◽  
Kayoko Shiba ◽  
Emi Ohki ◽  
Nanami Mutoh ◽  
Masahiko Suzuki ◽  
...  
Keyword(s):  
Comparative Study ◽  
Dermal Fibroblasts ◽  
Receptor Expression ◽  
Human Dermal Fibroblasts ◽  
Histamine H4 Receptor ◽  
H4 Receptor

Effects of atopy and grass pollen season on histamine H4 receptor expression in human leukocytes

2013 ◽  
Vol 111 (1) ◽  
pp. 38-44.e1 ◽  
Author(s):  
Emily Hodge ◽  
William Y.C. Chang ◽  
Katherine A. Selby ◽  
Ian P. Hall ◽  
Ian Sayers
Keyword(s):  
Grass Pollen ◽  
Pollen Season ◽  
Receptor Expression ◽  
Histamine H4 Receptor ◽  
Human Leukocytes ◽  
Grass Pollen Season ◽  
H4 Receptor

Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis

2015 ◽  
Vol 98 (1) ◽  
pp. 102-109 ◽  
Author(s):  
Bastian Schirmer ◽  
Thomas Rezniczek ◽  
Roland Seifert ◽  
Detlef Neumann
Keyword(s):  
Sodium Sulfate ◽  
Acute Colitis ◽  
Histamine H4 Receptor ◽  
H4 Receptor ◽  
Proinflammatory Role

Histamine H4 receptor expression is elevated in human nasal polyp tissue

2007 ◽  
Vol 31 (11) ◽  
pp. 1367-1370 ◽  
Author(s):  
Adrienn Jókúti ◽  
Éva Hellinger ◽  
Andrea Hellinger ◽  
Zsuzsa Darvas ◽  
András Falus ◽  
...  
Keyword(s):  
Nasal Polyp ◽  
Receptor Expression ◽  
Histamine H4 Receptor ◽  
Polyp Tissue ◽  
H4 Receptor

scholarly journals The Anaphylatoxin C3a Receptor Expression on Human M2 Macrophages Is Down-Regulated by Stimulating the Histamine H4 Receptor and the IL-4 Receptor

2018 ◽  
Vol 10 (4) ◽  
pp. 349-362 ◽  
Author(s):  
Susanne Mommert ◽  
Derya Aslan ◽  
Lisanne Ratz ◽  
Holger Stark ◽  
Ralf Gutzmer ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Receptor Expression ◽  
M2 Macrophages ◽  
Histamine H4 Receptor ◽  
Th2 Cytokine ◽  
H4 Receptor ◽  
Differentiation Marker ◽  
Anaphylatoxin C3a ◽  
G Protein Coupled

The anaphylatoxin C3a triggers inflammation by binding to its specific G-protein-coupled C3a receptor (C3aR). Since the number of C3aR, which is expressed on the cell surface, affects the response to C3a, we investigated the expression levels of C3aR on human M2 macrophages in allergic situations where high levels of the Th2 cytokine IL-4 and histamine are present in a local microenvironment. The histamine H1 receptor (H1R), H2R and the H4R mRNA expressions were induced or up-regulated during the differentiation process of M2 macrophages. The presence of histamine or agonists targeting the H1R, H2R and, in particular, the H4R during in vitro differentiation from monocytes to macrophages modified the M2 phenotype by regulating the macrophage differentiation marker CD68 and CD163 expressions. In ­addition, the C3aR expression was also down-regulated by ­ST-1006 during this process. Histamine and ST-1006 down-regulated the expression of C3aR with different time kinetics on fully differentiated M2 macrophages. By analysing C3a-induced IL-6 mRNA expression, we observed a diminished response to C3a in ST-1006-treated M2 macrophages when compared to un-treated cells. Expression of C3 was not affected by histamine, whereas IL-4 strongly down-regulated C3aR and C3 expressions. Our data suggests that down-regulation of C3aR expression by mediators present in allergic situations such as IL-4 or histamine has an anti-inflammatory impact by reducing the sensitivity to C3a-induced down-stream signaling, thereby contributing to the regulation of local inflammatory responses in the skin.

Histamine H4-receptor expression in the brain?

2014 ◽  
Vol 388 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Erich H. Schneider ◽  
Detlef Neumann ◽  
Roland Seifert
Keyword(s):  
Receptor Expression ◽  
Histamine H4 Receptor ◽  
H4 Receptor ◽  
The Brain

Targeting the Histamine H4 Receptor: Future Drugs for Inflammatory Diseases

2018 ◽  
Vol 22 (17) ◽  
pp. 1663-1672 ◽  
Author(s):  
Michelle Fidelis Correa ◽  
Joao Paulo dos Santos Fernandes
Keyword(s):  
Inflammatory Diseases ◽  
Histamine H4 Receptor ◽  
H4 Receptor

scholarly journals Mouse Colonic Epithelial Cells Functionally Express the Histamine H4 Receptor

2020 ◽  
Vol 373 (2) ◽  
pp. 167-174 ◽  
Author(s):  
Bastian Schirmer ◽  
Luisa Lindemann ◽  
Kaya Saskia Bittkau ◽  
Rukijat Isaev ◽  
Daniela Bösche ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Histamine H4 Receptor ◽  
Colonic Epithelial Cells ◽  
H4 Receptor
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