scholarly journals Experience-Related Changes in Place Cell Responses to New Sensory Configuration That Does Not Occur in the Natural Environment in the Rat Hippocampus

2017 ◽  
Vol 8 ◽  
Author(s):  
Dan Zou ◽  
Hiroshi Nishimaru ◽  
Jumpei Matsumoto ◽  
Yusaku Takamura ◽  
Taketoshi Ono ◽  
...  
Keyword(s):  
Natural Environment ◽  
Place Cell ◽  
Rat Hippocampus ◽  
Cell Responses

Post-ischemic potentiation of Schaffer collateral/CA1 pyramidal cell responses of the rat hippocampus in vivo: involvement of receptors

1993 ◽  
Vol 611 (1) ◽  
pp. 155-159 ◽  
Author(s):  
Shuhei Miyazaki ◽  
Yoichi Katayama ◽  
Makoto Furuichi ◽  
Kosaku Kinoshita ◽  
Tatsuro Kawamata ◽  
...  
Keyword(s):  
Pyramidal Cell ◽  
Rat Hippocampus ◽  
Schaffer Collateral ◽  
Cell Responses

scholarly journals Representation of Objects in Space by Two Classes of Hippocampal Pyramidal Cells

2004 ◽  
Vol 124 (1) ◽  
pp. 9-25 ◽  
Author(s):  
Bruno Rivard ◽  
Yu Li ◽  
Pierre-Pascal Lenck-Santini ◽  
Bruno Poucet ◽  
Robert U. Muller
Keyword(s):  
Cell Activity ◽  
Pyramidal Cells ◽  
Place Cell ◽  
Place Cells ◽  
Rat Hippocampus ◽  
Ca1 Pyramidal Cells ◽  
New Class ◽  
Familiar Environment ◽  
Current Arrangement ◽  
Number Of Cells

Humans can recognize and navigate in a room when its contents have been rearranged. Rats also adapt rapidly to movements of objects in a familiar environment. We therefore set out to investigate the neural machinery that underlies this capacity by further investigating the place cell–based map of the surroundings found in the rat hippocampus. We recorded from single CA1 pyramidal cells as rats foraged for food in a cylindrical arena (the room) containing a tall barrier (the furniture). Our main finding is a new class of cells that signal proximity to the barrier. If the barrier is fixed in position, these cells appear to be ordinary place cells. When, however, the barrier is moved, their activity moves equally and thereby conveys information about the barrier's position relative to the arena. When the barrier is removed, such cells stop firing, further suggesting they represent the barrier. Finally, if the barrier is put into a different arena where place cell activity is changed beyond recognition (“remapping”), these cells continue to discharge at the barrier. We also saw, in addition to barrier cells and place cells, a small number of cells whose activity seemed to require the barrier to be in a specific place in the environment. We conclude that barrier cells represent the location of the barrier in an environment-specific, place cell framework. The combined place + barrier cell activity thus mimics the current arrangement of the environment in an unexpectedly realistic fashion.

scholarly journals Spatially dispersed synapses yield sharply-tuned place cell responses through dendritic spike initiation

2017 ◽  
Author(s):  
Reshma Basak ◽  
Rishikesh Narayanan
Keyword(s):  
Critical Role ◽  
Place Cell ◽  
Place Field ◽  
Apparent Contradiction ◽  
Cell Responses ◽  
Sharp Feature ◽  
Dendritic Spikes ◽  
Feature Selectivity ◽  
Contradictory Evidence ◽  
Strong Candidate

The literature offers evidence for a critical role of spatially-clustered iso-feature synapses in eliciting dendritic spikes essential for sharp feature selectivity, with apparently contradictory evidence demonstrating spatial dispersion of iso-feature synapses. Here, we reconcile this apparent contradiction by demonstrating that the generation of dendritic spikes, the emergence of an excitatory ramp in somatic voltage responses and sharp tuning of place-cell responses are all attainable even when iso-feature synapses are randomly dispersed across the dendritic arbor. We found this tuning sharpness to be critically reliant on dendritic sodium and transient potassium channels and on N-methyl-D-aspartate receptors. Importantly, we demonstrate that synaptic potentiation targeted to afferents from one specific place field is sufficient to effectuate place-field selectivity even when intrinsically disparate neurons received randomly dispersed afferents from multiple place-field locations. These conclusions proffer dispersed localization of iso-feature synapses as a strong candidate for achieving sharp feature selectivity in neurons across sensory-perceptual systems.

Hippocampal place cell responses to distal and proximal cue manipulations in dopamine D2 receptor-knockout mice

2014 ◽  
Vol 1567 ◽  
pp. 13-27 ◽  
Author(s):  
Chien Le Nguyen ◽  
Anh Hai Tran ◽  
Jumpei Matsumoto ◽  
Etsuro Hori ◽  
Teruko Uwano ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Place Cell ◽  
Cell Responses ◽  
Dopamine D2 ◽  
Hippocampal Place Cell

scholarly journals A structured scaffold underlies activity in the hippocampus

2021 ◽  
Author(s):  
Dounia Mulders ◽  
Man Yi Yim ◽  
Jae Sung Lee ◽  
Albert K. Lee ◽  
Thibaud Taillefumier ◽  
...  
Keyword(s):  
Random Process ◽  
Grid Cell ◽  
Place Cell ◽  
Place Cells ◽  
Head Direction ◽  
Cell Responses ◽  
Neural Populations ◽  
External Cues ◽  
One Step ◽  
Design Experiments

Place cells are believed to organize memory across space and time, inspiring the idea of the cognitive map. Yet unlike the structured activity in the associated grid and head-direction cells, they remain an enigma: their responses have been difficult to predict and are complex enough to be statistically well-described by a random process. Here we report one step toward the ultimate goal of understanding place cells well enough to predict their fields. Within a theoretical framework in which place fields are derived as a conjunction of external cues with internal grid cell inputs, we predict that even apparently random place cell responses should reflect the structure of their grid inputs and that this structure can be unmasked if probed in sufficiently large neural populations and large environments. To test the theory, we design experiments in long, locally featureless spaces to demonstrate that structured scaffolds undergird place cell responses. Our findings, together with other theoretical and experimental results, suggest that place cells build memories of external inputs by attaching them to a largely prespecified grid scaffold.

Random isn't real: How the patchy distribution of ecological rewards may generate “incentive hope”

2019 ◽  
Vol 42 ◽  
Author(s):  
Laurel Symes ◽  
Thalia Wheatley
Keyword(s):  
Natural Environment ◽  
Random Distribution ◽  
Spatiotemporal Distribution ◽  
Patchy Distribution ◽  
Distribution Of Resources

AbstractAnselme & Güntürkün generate exciting new insights by integrating two disparate fields to explain why uncertain rewards produce strong motivational effects. Their conclusions are developed in a framework that assumes a random distribution of resources, uncommon in the natural environment. We argue that, by considering a realistically clumped spatiotemporal distribution of resources, their conclusions will be stronger and more complete.

Extreme self-sacrifice beyond fusion: Moral expansiveness and the special case of allyship

2018 ◽  
Vol 41 ◽  
Author(s):  
Daniel Crimston ◽  
Matthew J. Hornsey
Keyword(s):  
General Theory ◽  
Biological Markers ◽  
Natural Environment ◽  
Relevant Dimension ◽  
Special Case

AbstractAs a general theory of extreme self-sacrifice, Whitehouse's article misses one relevant dimension: people's willingness to fight and die in support of entities not bound by biological markers or ancestral kinship (allyship). We discuss research on moral expansiveness, which highlights individuals’ capacity to self-sacrifice for targets that lie outside traditional in-group markers, including racial out-groups, animals, and the natural environment.

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