scholarly journals Progression of Tubulointerstitial Fibrosis and the Chronic Kidney Disease Phenotype – Role of Risk Factors and Epigenetics

2017 ◽  
Vol 8 ◽  
Author(s):  
Timothy D. Hewitson ◽  
Stephen G. Holt ◽  
Edward R. Smith
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Tubulointerstitial Fibrosis ◽  
Disease Phenotype

scholarly journals Vascular dysfunction and atherosclerosis in chronic kidney disease; A distinct entity

2019 ◽  
Vol 8 (2) ◽  
pp. 17-17 ◽  
Author(s):  
Eranga Harshani Silva ◽  
Chandima Madhu Wickramatilake ◽  
Sarath Lekamwasam ◽  
Lakmini Kumari Boralugoda Mudduwa ◽  
Ranjuka Arushana Ubayasiri
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Dysfunction ◽  
Therapeutic Interventions ◽  
Cvd Risk ◽  
Unexplored Area ◽  
Calcium And Phosphate Metabolism ◽  
Conventional Risk Factors

Cardiovascular disease (CVD) is prevalent among patients with chronic kidney disease (CKD) and its occurrence and severity cannot be fully defined by the conventional cardiovascular risk factors namely age, hypertension, dyslipidaemia, diabetes mellitus and obesity. Contemporary studies have examined the role of non-conventional risk factors such as anemia, hyperhomocysteinemia, calcium and phosphate metabolism, vascular stiffness due to endothelial dysfunction ( ED), oxidative injury, and inflammation in the causation of CVD in CKD. Therapeutic interventions used in non-CKD patients are found to be less effective on patients with CKD. The purpose of this review was to gather available evidence on the CVD risk among CKD patients. Numerous mechanisms have been postulated to describe the increased atherogenicity in CKD patients. We discuss these mechanisms especially arterial stiffness, ED and inflammation in detail. In conclusion, CVD in CKD is still an unexplored area which needs further studies to uncover the possible mechanisms. Identifying newer therapies to improve health among this group of patients is of paramount importance.

scholarly journals Lipoprotein Abnormalities in Chronic Kidney Disease and Renal Transplantation

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 315
Author(s):  
Carlo Maria Barbagallo ◽  
Angelo Baldassare Cefalù ◽  
Antonina Giammanco ◽  
Davide Noto ◽  
Rosalia Caldarella ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Renal Transplantation ◽  
Kidney Disease ◽  
Lipoprotein Metabolism ◽  
History Of ◽  
Acute Changes ◽  
Progression Of Renal Disease

Chronic kidney disease (CKD) is one of the most important risk factors for cardiovascular disease (CVD). Despite the kidney having no direct implications for lipoproteins metabolism, advanced CKD dyslipidemia is usually present in patients with CKD, and the frequent lipid and lipoprotein alterations occurring in these patients play a role of primary importance in the development of CVD. Although hypertriglyceridemia is the main disorder, a number of lipoprotein abnormalities occur in these patients. Different enzymes pathways and proteins involved in lipoprotein metabolism are impaired in CKD. In addition, treatment of uremia may modify the expression of lipoprotein pattern as well as determine acute changes. In renal transplantation recipients, the main lipid alteration is hypercholesterolemia, while hypertriglyceridemia is less pronounced. In this review we have analyzed lipid and lipoprotein disturbances in CKD and also their relationship with progression of renal disease. Hypolipidemic treatments may also change the natural history of CVD in CKD patients and may represent important strategies in the management of CKD patients.

scholarly journals Role of Traditional Risk Factors and Antiretroviral Drugs in the Incidence of Chronic Kidney Disease, ANRS CO3 Aquitaine Cohort, France, 2004–2012

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66223 ◽  
Author(s):  
Philippe Morlat ◽  
Alexandre Vivot ◽  
Marie-Anne Vandenhende ◽  
Frédéric-Antoine Dauchy ◽  
Julien Asselineau ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Antiretroviral Drugs ◽  
Traditional Risk Factors

scholarly journals Diet Quality and Protein-Bound Uraemic Toxins: Investigation of Novel Risk Factors and the Role of Microbiome in Chronic Kidney Disease

2021 ◽  
Author(s):  
Catherine McFarlane ◽  
Rathika Krishnasamy ◽  
Tony Stanton ◽  
Emma Savill ◽  
Matthew Snelson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Diet Quality ◽  
Novel Risk Factors

Sugar-sweetened Beverages and Chronic Kidney Disease

2015 ◽  
Vol 11 (01) ◽  
pp. 41 ◽  
Author(s):  
Ke Wang ◽  
Ashish Upadhyay ◽  
◽  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Epidemiologic Studies ◽  
Sugar Consumption ◽  
Sugar Sweetened Beverages ◽  
Direct Role ◽  
Sweetened Beverages ◽  
The Us

Increasing consumption of sugar-sweetened beverages has occurred in parallel with the increasing prevalence of chronic kidney disease (CKD) in the US. Consumption of sugar-sweetened beverages, particularly with fructose, has been shown to play an important role in the pathogenesis of obesity, diabetes, hypertension, hyperuricemia, and nephrolithiasis, all of which are risk factors for CKD. However, the direct role of sugarsweetened beverages in the progression of CKD remains unclear. To date, five epidemiologic studies have examined the association between sugar consumption and kidney outcomes, with two showing statistically significant positive associations between higher sugar intake and adverse kidney outcomes. Even though the direct causal relationship between sugar-sweetened beverages and CKD has not been definitely established, it is advisable to counsel individuals with CKD and those at risk for CKD to limit the intake of sugar-sweetened beverages in light of its known detrimental effects on CKD risk factors.

scholarly journals Chronic Kidney Disease—Effect of Oxidative Stress

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Subha Palaneeswari Meenakshi Sundaram ◽  
Sivakumar Nagarajan ◽  
Arcot Jagdeeshwaran Manjula Devi
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Effect ◽  
Cv Disease ◽  
Stage Renal Disease ◽  
End Stage ◽  
Annual Mortality

Chronic kidney disease (CKD) is a growing health problem with increasing incidence. The annual mortality of end-stage renal disease patients is about 9%, which is 10–20 fold higher than the general population, approximately 50% of these deaths are due to cardiovascular (CV) disease. CV risk factors, such as diabetes, hypertension, and hyperlipidemia, are strongly associated with poor outcome. Many other nontraditional risk factors such as inflammation, infection, oxidative stress, anemia, and malnutrition are also present. In this review we will focus on the role of oxidative stress in chronic kidney disease.

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