scholarly journals UTP – Gated Signaling Pathways of 5-HT Release from BON Cells as a Model of Human Enterochromaffin Cells

2017 ◽  
Vol 8 ◽  
Author(s):  
Andromeda Liñán-Rico ◽  
Fernando Ochoa-Cortes ◽  
Alix Zuleta-Alarcon ◽  
Mazin Alhaj ◽  
Esmerina Tili ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Enterochromaffin Cells ◽  
Bon Cells

scholarly journals Mechanical stimulation activates Gαq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells

2001 ◽  
Vol 108 (7) ◽  
pp. 1051-1059 ◽  
Author(s):  
Minsoo Kim ◽  
Najma H. Javed ◽  
Jun-Ge Yu ◽  
Fievos Christofi ◽  
Helen J. Cooke
Keyword(s):  
Signaling Pathways ◽  
Mechanical Stimulation ◽  
Bon Cells

D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells

2001 ◽  
Vol 121 (6) ◽  
pp. 1400-1406 ◽  
Author(s):  
Minsoo Kim ◽  
Helen J. Cooke ◽  
Najma H. Javed ◽  
Hannah V. Carey ◽  
Fievos Christofi ◽  
...  
Keyword(s):  
Enterochromaffin Cells ◽  
Bon Cells

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

2020 ◽  
Vol 134 (5) ◽  
pp. 473-512 ◽  
Author(s):  
Ryan P. Ceddia ◽  
Sheila Collins
Keyword(s):  
Adipose Tissue ◽  
Energy Expenditure ◽  
Signaling Pathways ◽  
G Protein ◽  
Uncoupling Protein ◽  
Beige Adipocytes ◽  
Nucleotide Regulation ◽  
Ucp1 Expression ◽  
Thermogenic Adipocytes ◽  
G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

Mechanical stimulation of human BON cells: Gαq involvement in 5-HT release

2001 ◽  
Vol 120 (5) ◽  
pp. A83-A83
Author(s):  
M KIM ◽  
N JAVED ◽  
F CHRISTOFI ◽  
H COOKE
Keyword(s):  
Mechanical Stimulation ◽  
Bon Cells ◽  
Stimulation Of

Synthesis and secretion of atrial natriuretic peptide by BON cells: Stimulation by PMA and cGMP

2001 ◽  
Vol 120 (5) ◽  
pp. A682-A682
Author(s):  
W GOWERJR ◽  
G CARTER ◽  
C LANDON ◽  
W GOWERIII ◽  
J DIETZ ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Bon Cells ◽  
Atrial Natriuretic

Action of curcumin and its synthetic analog CDF on cancer related signaling pathways

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
P Balachandran ◽  
FH Sarkar ◽  
DS Pasco
Keyword(s):  
Signaling Pathways ◽  
Synthetic Analog
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