scholarly journals Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells

2017 ◽  
Vol 8 ◽  
Author(s):  
Onat Kadioglu ◽  
Betty Y. K. Law ◽  
Simon W. F. Mok ◽  
Su-Wei Xu ◽  
Thomas Efferth ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Mode Of Action ◽  
Multidrug Resistant ◽  
Nelumbo Nucifera ◽  
Bisbenzylisoquinoline Alkaloid

scholarly journals Clusters, Assemblies and Aggregates of Tumor Cells in the Blood of Breast Cancer Patients; Composition, Mode of Action, Detection and Impact on Metastasis and Survival

2021 ◽  
Vol 1 (1) ◽  
pp. 55-68
Author(s):  
Urszula Smietanka ◽  
Małgorzata Szostakowska-Rodzos ◽  
Sylwia Tabor ◽  
Anna Fabisiewicz ◽  
Ewa A. Grzybowska
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Diagnostic Tool ◽  
Therapeutic Target ◽  
Mode Of Action ◽  
Breast Cancer Patients ◽  
Single Ctcs ◽  
Methods Of Isolation

Circulating tumor cells (CTCs) are gaining momentum as a diagnostic tool and therapeutic target. CTC clusters are more metastatic, but harder to study and characterize, because they are rare and the methods of isolation are mostly focused on single CTCs. This review highlights the recent advances to our understanding of tumor cell clusters with the emphasis on their composition, origin, biology, methods of detection, and impact on metastasis and survival. New approaches to therapy, based on cluster characteristics are also described.

An updated review on pharmacological properties of neferine—A bisbenzylisoquinoline alkaloid from Nelumbo nucifera

2021 ◽  
Author(s):  
Lohanathan Bharathi Priya ◽  
Chih‐Yang Huang ◽  
Rouh‐Mei Hu ◽  
Balamuralikrishnan Balasubramanian ◽  
Rathinasamy Baskaran
Keyword(s):  
Nelumbo Nucifera ◽  
Pharmacological Properties ◽  
Bisbenzylisoquinoline Alkaloid

Expression of the IAPs in multidrug resistant tumor cells

2004 ◽  
Author(s):  
Monica Notarbartolo ◽  
Melchiorre Cervello ◽  
Paola Poma ◽  
Luisa Dusonchet ◽  
Maria Meli ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Multidrug Resistant

scholarly journals Reversal of Multidrug Resistance by 7-O-Benzoylpyripyropene A in Multidrug-Resistant Tumor Cells.

2000 ◽  
Vol 53 (10) ◽  
pp. 1201-1206 ◽  
Author(s):  
MUN-CHUAL RHO ◽  
MASAHIKO HAYASHI ◽  
AKIKO FUKAMI ◽  
RIKA OBATA ◽  
TOSHIAKI SUNAZUKA ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Tumor Cells ◽  
Multidrug Resistant

scholarly journals The Bewildering Antitubercular Action of Pyrazinamide

2020 ◽  
Vol 84 (2) ◽  
Author(s):  
Elise A. Lamont ◽  
Nicholas A. Dillon ◽  
Anthony D. Baughn
Keyword(s):  
Mode Of Action ◽  
Rational Design ◽  
Multidrug Resistant ◽  
Future Research ◽  
Therapeutic Approaches ◽  
Treatment Regimens ◽  
Tb Treatment ◽  
Short Course ◽  
Recent Developments ◽  
Susceptibility And Resistance

SUMMARY Pyrazinamide (PZA) is a cornerstone antimicrobial drug used exclusively for the treatment of tuberculosis (TB). Due to its ability to shorten drug therapy by 3 months and reduce disease relapse rates, PZA is considered an irreplaceable component of standard first-line short-course therapy for drug-susceptible TB and second-line treatment regimens for multidrug-resistant TB. Despite over 60 years of research on PZA and its crucial role in current and future TB treatment regimens, the mode of action of this unique drug remains unclear. Defining the mode of action for PZA will open new avenues for rational design of novel therapeutic approaches for the treatment of TB. In this review, we discuss the four prevailing models for PZA action, recent developments in modulation of PZA susceptibility and resistance, and outlooks for future research and drug development.

scholarly journals Monoclonal Anti-P-glycoprotein Antibody-dependent Killing of Multidrug-resistant Tumor Cells by Human Mononuclear Cells

1990 ◽  
Vol 81 (11) ◽  
pp. 1155-1161 ◽  
Author(s):  
Yuji Heike ◽  
Hirofumi Hamada ◽  
Noriaki Inamura ◽  
Saburo Sone ◽  
Takeshi Ogura ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Mononuclear Cells ◽  
Multidrug Resistant ◽  
Human Mononuclear Cells ◽  
P Glycoprotein
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