scholarly journals Curcumin Ameliorates Cisplatin-Induced Nephrotoxicity and Potentiates Its Anticancer Activity in SD Rats: Potential Role of Curcumin in Breast Cancer Chemotherapy

2017 ◽  
Vol 8 ◽  
Author(s):  
Parveen Kumar ◽  
Chandana C. Barua ◽  
Kunjbihari Sulakhiya ◽  
Rajeev Kumar Sharma
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Cancer Chemotherapy ◽  
Potential Role ◽  
Breast Cancer Chemotherapy ◽  
Sd Rats

scholarly journals Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic

2021 ◽  
Author(s):  
Marie Mclaughlin ◽  
Geraint Florida-James ◽  
Mark Ross
Keyword(s):  
Breast Cancer ◽  
Cancer Chemotherapy ◽  
Potential Role ◽  
Vascular Toxicity ◽  
Exercise Interventions ◽  
Breast Cancer Chemotherapy ◽  
Mediating Mechanisms ◽  
The Impact ◽  
Health Function

Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its central importance within the cardiovascular system and resultant detrimental effects of damage and dysfunction. This review highlights the impact of chemotherapy for breast cancer on the vascular endothelium. We consider the most likely mechanisms of endothelial toxicity to be through direct damage and dysfunction of the endothelium. There are sharp consequences of these detrimental effects as they can lead to cardiovascular disease. However, there is potential for exercise to alleviate some of the vascular toxicity of chemotherapy, and the evidence for this is provided. The potential role of exercise in protecting against vascular toxicity is explained, highlighting the recent in-human and animal model exercise interventions. Lastly, the mediating mechanisms of exercise protection of endothelial health is discussed, focusing on the importance of exercise for endothelial health, function, repair, inflammation and hyperlipidaemia, angiogenesis, and vascular remodelling. These are all important counteracting measures against chemotherapy-induced toxicity and are discussed in detail.

scholarly journals Narrowing racial gaps in breast cancer chemotherapy initiation: the role of the patient–provider relationship

2013 ◽  
Vol 139 (1) ◽  
pp. 207-216 ◽  
Author(s):  
Vanessa B. Sheppard ◽  
Claudine Isaacs ◽  
George Luta ◽  
Shawna C. Willey ◽  
Marc Boisvert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Chemotherapy ◽  
Breast Cancer Chemotherapy ◽  
Racial Gaps ◽  
Chemotherapy Initiation
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