scholarly journals Dual Functional Capability of Dendritic Cells – Cytokine-Induced Killer Cells in Improving Side Effects of Colorectal Cancer Therapy

2017 ◽  
Vol 8 ◽  
Author(s):  
Paula Mosińska ◽  
Agata Gabryelska ◽  
Malwina Zasada ◽  
Jakub Fichna
Keyword(s):  
Colorectal Cancer ◽  
Dendritic Cells ◽  
Side Effects ◽  
Cancer Therapy ◽  
Functional Capability ◽  
Killer Cells ◽  
Dual Functional

Targeting vitamin E TPGS–cantharidin conjugate nanoparticles for colorectal cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (66) ◽  
pp. 53846-53856 ◽  
Author(s):  
Shihou Sheng ◽  
Tao Zhang ◽  
Shijie Li ◽  
Jun Wei ◽  
Guangjun Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Vitamin E ◽  
Chinese Medicine ◽  
Side Effects ◽  
Cancer Therapy ◽  
Traditional Chinese Medicine ◽  
Drug Efficacy ◽  
Vitamin E Tpgs ◽  
Colorectal Cancer Cells

A traditional Chinese medicine cantharidin which was previously found to be effective on colorectal cancer cells was translated into nanoparticles for drug delivery to reduce its side effects and enhance its drug efficacy.

The dual-functional capability of cytokine-induced killer cells and application in tumor immunology

2015 ◽  
Vol 76 (5) ◽  
pp. 385-391 ◽  
Author(s):  
Qiang Zhang ◽  
Xiao-yan Liu ◽  
Teng Zhang ◽  
Xin-feng Zhang ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Tumor Immunology ◽  
Functional Capability ◽  
Killer Cells ◽  
Dual Functional

scholarly journals FOLFOX regimen plus dendritic cells–cytokine-induced killer cells immunotherapy for the treatment of colorectal cancer: a meta-analysis

2017 ◽  
Vol Volume 10 ◽  
pp. 2621-2633 ◽  
Author(s):  
Yan Liu ◽  
Zhong Zheng ◽  
Qixin Zhang ◽  
Xinling Zhou ◽  
Yikuan Feng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dendritic Cells ◽  
Meta Analysis ◽  
Killer Cells

scholarly journals IMMUNOTHERAPY BASED ON DENDRITIC CELLS IN BLADDER CANCER TREATMENT

2018 ◽  
Vol 5 (2) ◽  
pp. 16-23
Author(s):  
A. S. Ilnitskaya ◽  
A. B. Danilova ◽  
I. A. Baldueva
Keyword(s):  
Bladder Cancer ◽  
Dendritic Cells ◽  
Side Effects ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Relevant Today ◽  
Vaccine Treatment ◽  
Antitumor Vaccine ◽  
Methods Of Treatment ◽  
Selection Of

The development of an antitumor vaccine based on autologous dendritic cells (DCs) for bladder cancer treatment is extremely relevant today due to the proven high immunological potency of this type of tumor. Vaccination with DCs-based drugs as a monotherapy or in combination with other methods of treatment has shown to be effective in cancer therapy. The vaccine administration is considered to be safe, the associated side effects are insignificant and can be characterized as undesirable phenomena of 1st or 2nd degree. There are a number of issues that arise while creating DCs vaccines that need to be carefully resolved. Among them, the problem of selecting potential targets for the vaccine treatment, the ways to enhance the potency of the vaccine, and the selection of technology for obtaining a sufficient number of functional DCs should be specifically mentioned. The review focuses on the use of autoantigen or alloantibody material for the activation of DCs, and the results of experimental and clinical studies of DCs vaccines in bladder cancer.

Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

2020 ◽  
Vol 27 (13) ◽  
pp. 2118-2132 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Hakan Ozben ◽  
Ferhat Hanikoglu ◽  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Side Effects ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Agents ◽  
Oxidation Reactions ◽  
Hybrid Compounds ◽  
Induced Apoptosis

: Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative stress induced apoptosis and hybrid anticancer drugs.

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