scholarly journals Multipronged Therapeutic Effects of Chinese Herbal Medicine Qishenyiqi in the Treatment of Acute Myocardial Infarction

2017 ◽  
Vol 8 ◽  
Author(s):  
Yong Wang ◽  
Weili Lin ◽  
Chun Li ◽  
Sarita Singhal ◽  
Gaurav Jain ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Therapeutic Effects ◽  
Chinese Herbal

Treatment of atopic dermatitis with Chinese herbal medicine. Therapeutic effects of Hochuekkitou.

1989 ◽  
Vol 51 (5) ◽  
pp. 1003-1013 ◽  
Author(s):  
Hiromi KOBAYASHI ◽  
Masamitsu ISHII ◽  
Tsukasa TANII ◽  
Takeshi KOHNO ◽  
Toshio HAMADA
Keyword(s):  
Atopic Dermatitis ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Therapeutic Effects ◽  
Chinese Herbal

scholarly journals Chinese Herbal Medicine Bushen Qinggan Formula for Blood Pressure Variability and Endothelial Injury in Hypertensive Patients: A Randomized Controlled Pilot Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chunxiao Wu ◽  
Jingchun Zhang ◽  
Yingke Zhao ◽  
Jing Chen ◽  
Yue Liu
Keyword(s):  
Blood Pressure ◽  
Herbal Medicine ◽  
Endothelial Function ◽  
Chinese Herbal Medicine ◽  
Blood Pressure Variability ◽  
Endothelial Injury ◽  
Control Group ◽  
Therapeutic Effects ◽  
Chinese Herbal ◽  
Significant Difference

Background.Blood pressure variability (BPV) independent of average blood pressure is related to cardiovascular damage. Meanwhile, BPV is also associated with measures of endothelial injury. Decoction, a traditional used form of Traditional Chinese Medicine (TCM), is inconvenient to prepare, carry, and store. Dispensing granules is now developing as an alternative to decoction, but the evidence supporting its clinical efficacy the same as decoction remains unclear.Objective.To examine the therapeutic effects on mean blood pressure (MBP), blood pressure variability, and endothelial function by giving Bushen Qinggan Formula, a compound Chinese Herbal Medicine and also to evaluate the difference in efficacy between decoction and granule.Methods.A total of 150 patients with hypertension were enrolled and randomly assigned to receive the placebo, Bushen Qinggan decoction, or Bushen Qinggan granule in addition to the standard medications (amlodipine-5 mg/d) for the treatment of essential hypertension (EH). The outcome was the reduction in the MBP and BPV and also included changes in the endothelial markers including endothelin-1 (ET-1) and nitric oxide (NO) after 8 weeks of treatment.Results.Compared with the control group, the Bushen Qinggan decoction and granule groups had significant improvement (P<0.01) in BPV and endothelial founction. The level of BPV and endothelial function between decoction and granule group had no significant difference (P>0.05).Conclusion.Based on the standard treatment, Bushen Qinggan Formula further improved BPV and endothelial function. The efficacy of Bushen Qinggan decoction and granule is similar in improving BPV and endothelial function. However, no significant antihypertensive effects could be demonstrated.

Regulatory Role Of Chinese Herbal Medicine In Regulated Neuronal Death

2020 ◽  
Vol 19 ◽  
Author(s):  
Xiuyu Wu ◽  
Ximin Hu ◽  
Qi Zhang ◽  
Fengxia Liu ◽  
Kun Xiong
Keyword(s):  
Cell Death ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Synergistic Effects ◽  
Neuronal Injury ◽  
Therapeutic Effects ◽  
Chinese Herbal ◽  
Regulated Cell Death ◽  
Nitrative Stress ◽  
Ischemic Neuronal Injury

: Ischemic neuronal injury results from a complex series of pathophysiological events, including oxidative, excitotoxicity, inflammation and nitrative stress. Consequently, many of these events can induce cell death, including necrosis (unregulated cell death) and apoptosis (a type of regulated cell death). These are long-established paradigms to which newly discovered regulated cell death processes have been added, such as necroptosis (a regulated form of necrosis) and autophagy-dependent cell death. Moreover, many researchers have targeted products associated with Chinese herbal medicine at regulated pathways for the treatment of ischemic neuronal injury. In East Asia, these drugs have been known for centuries to protect and improve the nervous system. Herbal extracts, especially those used in Chinese herbal medicine, have emerged as new pharmaceuticals for the treatment of ischemic neuronal injury. Here, we review the evidence from preclinical studies investigating the neuroprotective properties and therapeutic application of Chinese herbal medicines (Chinese herbal monomer, extract, and medicinal compounds) and highlight the potential mechanisms underlying their therapeutic effects via targeting different regulated cell death pathways. Notably, many herbs have been shown to target multiple mechanisms of regulated cell death and, in combination, may exert synergistic effects on signaling pathways, thereby attenuating multiple aspects of ischemic pathology. In this review, we summarize a general regulated pathway of cell death as a target for novel natural herbal regimens against ischemic neuronal injury.

scholarly journals Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Kuo-Jen Wu ◽  
Yuh-Fung Chen ◽  
Huei-Yann Tsai ◽  
Chi-Rei Wu ◽  
W. Gibson Wood
Keyword(s):  
Diabetes Mellitus ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Neuronal Apoptosis ◽  
Caspase 3 ◽  
Memory Deficits ◽  
Therapeutic Effects ◽  
Apoptosis Pathway ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal

Brain neuronal apoptosis and cognitive impairment are associated with hyperglycemia and diabetes mellitus. The present study determined if the Chinese herbal medicineGuizhi-Fuling-Wan(GFW) would reduce memory loss and neuronal apoptosis in streptozotocin- (STZ-) induced hyperglycemic rodents. Two weeks after STZ induction, GFW was orally administered once daily for 7 days. GFW significantly improved spatial memory deficits in STZ-induced hyperglycemic mice. GFW decreased TUNEL-positive cells and caspase-3 positive cells in STZ-induced hyperglycemic rats. It also was found that GFW treatment reduced caspase-3 protein levels and increased levels of the antiapoptotic protein Bcl-2 that were indicative of neuroprotection. The protective therapeutic effects of GFW on neuronal apoptosis and cognition deficits caused by STZ-induced hyperglycemia may be due in part to inhibition of the cellular apoptosis pathway. GFW may have therapeutic effects in patients with diabetes-mellitus-induced neuropathology.

scholarly journals Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation

2021 ◽  
Vol 12 ◽  
Author(s):  
Wenqian Guo ◽  
Han Ma ◽  
Chong-Zhi Wang ◽  
Jin-Yi Wan ◽  
Haiqiang Yao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Bioactive Compound ◽  
Plant Responses ◽  
Therapeutic Effects ◽  
Health Maintenance ◽  
Cellular Processes ◽  
Chinese Herbal

Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treatment of multiple diseases. Newly developed epigenetic techniques have brought great opportunities for the development of CHM. In this review, we summarize the DNA methylation studies and portray the pleiotropic role of DNA methylation in CHM. DNA methylation serves as a mediator participating in plant responses to environmental factors, and thus affecting CHM medicinal plants growth and bioactive compound biosynthesis which are vital for therapeutic effects. Furthermore, DNA methylation helps to uncover the pharmaceutical mechanisms of CHM formulae, herbs, and herbal-derived compounds. It also provides scientific validation for constitution theory and other essential issues of CHM. This newly developed field of DNA methylation is up-and-coming to address many complicated scientific questions of CHM; it thus not only promotes disease treatment but also facilitates health maintenance.

scholarly journals The Therapeutic Effects of the Chinese Herbal Medicine, Lang Chuang Fang Granule, on Lupus-Prone MRL/lprMice

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Kai-Peng Huang ◽  
Zhi-Hao Zhang ◽  
Rui-Ming Li ◽  
Xiao Chen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Lupus Erythematosus ◽  
Therapeutic Effects ◽  
Systemic Lupus ◽  
Treatment Groups ◽  
Beneficial Effects ◽  
Chinese Herbal ◽  
Chronic Autoimmune Disease

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that leads to severe multiorgan damage. Lang Chuang Fang (LCF) is a Chinese herbal medicine that is clinically prescribed for treating SLE. In this study, we examined the therapeutic effects of LCF granule on lupus-prone MRL/lprmice. Female mice were randomly separated into six groups, and LCF treatment groups received LCF granule at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, respectively. Here, we found that, compared to the MRL/lprmice, both the spleen coefficient and thymus coefficient were reduced in the LCF granule-treated mice. There was a marked downregulation in CRP and anti-dsDNA autoantibody and an evident upregulation of CH50 in LCF granule-treated mice. LCF granule treatment also obviously reduced the proteinuria, BUN, and SCr levels in MRL/lprmice at the dosage of 0.97 g/kg/d, 1.95 g/kg/d, and 3.90 g/kg/d, indicating that LCF granule alleviated the renal injury of MRL/lprmice. Furthermore, LCF granule decreased p65 NF-κB levels and increased Sirt1 and Nrf2 levels in the kidney tissues of MRL/lprmice, which might elucidate the beneficial effects of LCF on lupus nephritis. In conclusion, this study demonstrates that LCF granule has therapeutic effects on lupus-prone MRL/lprmice.

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