scholarly journals Pomegranate Extract Enhances Endothelium-Dependent Coronary Relaxation in Isolated Perfused Hearts from Spontaneously Hypertensive Ovariectomized Rats

2017 ◽  
Vol 7 ◽  
Author(s):  
Nathalie T. B. Delgado ◽  
Wender do N. Rouver ◽  
Leandro C. Freitas-Lima ◽  
Tiago D.-C. de Paula ◽  
Andressa Duarte ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Spontaneously Hypertensive ◽  
Perfused Hearts ◽  
Coronary Relaxation

Ubiquinol–cytochrome-c reductase 7.2 kDa protein of mitochondrial complex III is steroid-responsive and increases in cardiac hypertrophy and hypertension

2007 ◽  
Vol 85 (10) ◽  
pp. 986-996 ◽  
Author(s):  
Hung Huynh ◽  
Nicolas Servant ◽  
Lorraine E. Chalifour
Keyword(s):  
Cytochrome C ◽  
Cardiac Hypertrophy ◽  
Premenopausal Women ◽  
Complex Iii ◽  
Ovariectomized Rats ◽  
Spontaneously Hypertensive ◽  
Cytochrome C Reductase ◽  
Mitochondrial Respiratory Complex ◽  
Wistar Kyoto ◽  
Intact Rats

Women and men do not respond identically to cardiac insults; premenopausal women are somewhat protected from cardiovascular disease. Our objective was to isolate and characterize hormone-responsive genes in the heart. Differential display identified an estrogen-inducible fragment that was found to encode the ubiquinol–cytochrome-c reductase (UCCR) 7.2 kDa protein of the mitochondrial respiratory complex III. We found UCCR7.2 mRNA to be highly expressed in the heart, and this expression increased in hearts of 4-, 10-, and 28-week-old spontaneously hypertensive rats (SHR) compared with normotensive Wistar–Kyoto rats. Oral hydralazine treatment to reduce hypertension reduced SHR UCCR7.2 expression. Cardiac UCCR7.2 mRNA expression was also increased significantly after a 5/6 nephrectomy compared with mock surgery. Cardiac expression after ovariectomy was 50% that of intact rats. Supplementation of ovariectomized rats with estrogen had no effect, whereas progesterone increased cardiac expression, although not to intact levels. No change in cardiac UCCR7.2 expression was found when intact rats were treated with either tamoxifen or ICI 182780. Thus, UCCR7.2 expression is reduced in the absence of ovarian hormones, but is not directly regulated by estrogen in the heart. We conclude that UCCR7.2 is a steroid hormone-responsive gene in the heart, with expression increased in cardiac hypertrophy and in response to hypertension.

A comparison of the uterotrophic response in cyclic and ovariectomized normotensive and spontaneously hypertensive rats

1992 ◽  
Vol 135 (2) ◽  
pp. 263-269 ◽  
Author(s):  
M. B. Kerr ◽  
K. Marshall ◽  
J. Senior
Keyword(s):  
Blood Flow ◽  
Dry Weight ◽  
Ovariectomized Rats ◽  
Target Tissue ◽  
Temporal Response ◽  
Hypertensive Rats ◽  
Maximum Weight ◽  
Spontaneously Hypertensive ◽  
Water Imbibition ◽  
Hyperaemic Response

ABSTRACT The uterotrophic response in the normotensive (CD) and the hypertensive (SHR) rat was compared in intact cyclic rats and in ovariectomized rats given oestradiol. The parameters measured were blood flow, and uterine wet and dry weights. In the cyclic animals blood flow to the oestogen target tissue varied throughout the oestrous cycle, peak flows being achieved at pro-oestrus; in the SHR rat, however, the pro-oestrous maximum was significantly attenuated compared with the CD rat. Uterine wet and dry weights were similar. The temporal response to oestradiol in ovariectomized rats showed that in the CD rat the hyperaemic response peaked earlier than in the SHR rat, significant changes in terms of increased water imbibition also occurred more quickly in the CD strain. In both strains, uterine dry weight was the last parameter to be significantly increased, the maximum weight being attained more quickly in the SHR rat. The results of this study indicated that it is the blood flow to the oestrogen target tissues of the uterus and vagina that is most susceptible to change with strain of rat. Journal of Endocrinology (1992) 135, 263–269

scholarly journals Effects of progesterone treatment on endothelium-dependent coronary relaxation in ovariectomized rats

Life Sciences ◽  
2020 ◽  
Vol 247 ◽  
pp. 117391
Author(s):  
Tagana Rosa da Cunha ◽  
Jéssyca Aparecida Soares Giesen ◽  
Wender Nascimento Rouver ◽  
Eduardo Damasceno Costa ◽  
Marcella Daruge Grando ◽  
...  
Keyword(s):  
Ovariectomized Rats ◽  
Progesterone Treatment ◽  
Coronary Relaxation

Isoproterenol and glucagon effects in perfused hearts from spontaneously hypertensive and normotensive rats

1973 ◽  
Vol 22 (14) ◽  
pp. 1735-1744 ◽  
Author(s):  
Elwood E. Largis ◽  
Donald O. Allen ◽  
Julia Clark ◽  
James Ashmore
Keyword(s):  
Spontaneously Hypertensive ◽  
Perfused Hearts
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