scholarly journals Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury

2016 ◽  
Vol 7 ◽  
Author(s):  
Chad A. Lerner ◽  
Wei Lei ◽  
Isaac K. Sundar ◽  
Irfan Rahman
Keyword(s):  
Cigarette Smoke ◽  
Lung Inflammation ◽  
Genetic Ablation

scholarly journals Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice

2008 ◽  
Vol 172 (5) ◽  
pp. 1222-1237 ◽  
Author(s):  
Hongwei Yao ◽  
Indika Edirisinghe ◽  
Se-Ran Yang ◽  
Saravanan Rajendrasozhan ◽  
Aruna Kode ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Cigarette Smoke ◽  
Lung Inflammation ◽  
Genetic Ablation

Effects of intranasal azithromycin on features of cigarette smoke-induced lung inflammation

2021 ◽  
pp. 174467
Author(s):  
Siddhi Jain ◽  
Sneha Durugkar ◽  
Pritam Saha ◽  
Sharad B. Gokhale ◽  
V.G.M. Naidu ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Lung Inflammation

scholarly journals p53- and PAI-1-mediated induction of C-X-C chemokines and CXCR2: importance in pulmonary inflammation due to cigarette smoke exposure

2016 ◽  
Vol 310 (6) ◽  
pp. L496-L506 ◽  
Author(s):  
Nivedita Tiwari ◽  
Amarnath S. Marudamuthu ◽  
Yoshikazu Tsukasaki ◽  
Mitsuo Ikebe ◽  
Jian Fu ◽  
...  
Keyword(s):  
Lung Injury ◽  
Cigarette Smoke ◽  
Lung Inflammation ◽  
Cellular Adhesion ◽  
Alveolar Epithelial Cells ◽  
Cigarette Smoke Exposure ◽  
Chronic Obstructive ◽  
P53 Expression ◽  
Cellular Adhesion Molecule ◽  
Pai 1

We previously demonstrated that tumor suppressor protein p53 augments plasminogen activator inhibitor-1 (PAI-1) expression in alveolar epithelial cells (AECs) during chronic cigarette smoke (CS) exposure-induced lung injury. Chronic lung inflammation with elevated p53 and PAI-1 expression in AECs and increased susceptibility to and exacerbation of respiratory infections are all associated with chronic obstructive pulmonary disease (COPD). We recently demonstrated that preventing p53 from binding to the endogenous PAI-1 mRNA in AECs by either suppressing p53 expression or blockading p53 interactions with the PAI-1 mRNA mitigates apoptosis and lung injury. Within this context, we now show increased expression of the C-X-C chemokines (CXCL1 and CXCL2) and their receptor CXCR2, and the intercellular cellular adhesion molecule-1 (ICAM-1), in the lung tissues of patients with COPD. We also found a similar increase in lung tissues and AECs from wild-type (WT) mice exposed to passive CS for 20 wk and in primary AECs treated with CS extract in vitro. Interestingly, passive CS exposure of mice lacking either p53 or PAI-1 expression resisted an increase in CXCL1, CXCL2, CXCR2, and ICAM-1. Furthermore, inhibition of p53-mediated induction of PAI-1 expression by treatment of WT mice exposed to passive CS with caveolin-1 scaffolding domain peptide reduced CXCL1, CXCL2, and CXCR2 levels and lung inflammation. Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2. We further provide evidence that targeting this pathway mitigates lung injury associated with chronic CS exposure.

scholarly journals Early Detection of Susceptibility to Acute Lung Inflammation by Molecular Imaging in Mice Exposed to Cigarette Smoke

2011 ◽  
Vol 10 (5) ◽  
pp. 7290.2011.00010 ◽  
Author(s):  
Sandra Pérez-Rial ◽  
Laura del Puerto-Nevado ◽  
Nicolás González-Mangado ◽  
Germán Peces-Barba
Keyword(s):  
Molecular Imaging ◽  
Early Detection ◽  
Cigarette Smoke ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58258 ◽  
Author(s):  
Hsi-Min Hsiao ◽  
Ramil E. Sapinoro ◽  
Thomas H. Thatcher ◽  
Amanda Croasdell ◽  
Elizabeth P. Levy ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Lung Inflammation ◽  
Resolvin D1 ◽  
Anti Inflammatory
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