scholarly journals Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin

2016 ◽  
Vol 7 ◽  
Author(s):  
Koji Takeuchi ◽  
Takuya Endoh ◽  
Shusaku Hayashi ◽  
Takeshi Aihara
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Acetylcholine Receptor ◽  
Muscarinic Acetylcholine Receptor ◽  
Receptor Subtype ◽  
Cholinergic Stimulation ◽  
Muscarinic Acetylcholine ◽  
D Cell ◽  
Stimulation Of

scholarly journals Cholinergically stimulated gastric acid secretion is mediated by M3 and M5 but not M1 muscarinic acetylcholine receptors in mice

2005 ◽  
Vol 288 (6) ◽  
pp. G1199-G1207 ◽  
Author(s):  
Takeshi Aihara ◽  
Yusuke Nakamura ◽  
Makoto M. Taketo ◽  
Minoru Matsui ◽  
Susumu Okabe
Keyword(s):  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Receptor Subtype ◽  
Gastric Fistula ◽  
Antral Mucosa ◽  
Dependent Manner ◽  
Muscarinic Acetylcholine

Muscarinic acetylcholine receptors play an important role in the regulation of gastric acid secretion stimulated by acetylcholine; nonetheless, the precise role of each receptor subtype (M1–M5) remains unclear. This study examined the involvement of M1, M3, and M5 receptors in cholinergic regulation of acid secretion using muscarinic receptor knockout (KO) mice. Gastric acid secretion was measured in both mice subjected to acute gastric fistula production under urethane anesthesia and conscious mice that had previously undergone pylorus ligation. M3 KO mice exhibited impaired gastric acid secretion in response to carbachol. Unexpectedly, M1 KO mice exhibited normal intragastric pH, serum gastrin and mucosal histamine levels, and gastric acid secretion stimulatied by carbachol, histamine, and gastrin. Pirenzepine, known as an M1-receptor antagonist, inhibited carbachol-stimulated gastric acid secretion in a dose-dependent manner in M1 KO mice as well as in wild-type (WT) mice, suggesting that the inhibitory effect of pirenzepine on gastric acid secretion is independent of M1-receptor antagonism. Notably, M5 KO mice exhibited both significantly lower carbachol-stimulated gastric acid secretion and histamine-secretory responses to carbachol compared with WT mice. RT-PCR analysis revealed M5-mRNA expression in the stomach, but not in either the fundic or antral mucosa. Consequently, cholinergic stimulation of gastric acid secretion is clearly mediated by M3 (on parietal cells) and M5 receptors (conceivably in the submucosal plexus), but not M1 receptors.

Electrical stimulation of the medial amygdala facilitates gastric acid secretion in conscious rats

1990 ◽  
Vol 524 (2) ◽  
pp. 208-212 ◽  
Author(s):  
Myung Suk Kim ◽  
Yang Hyeok Jo ◽  
Shin Hee Yoon ◽  
Sang June Hahn ◽  
Duck Joo Rhie ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Medial Amygdala ◽  
Conscious Rats ◽  
Stimulation Of
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