scholarly journals Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes

2016 ◽  
Vol 7 ◽  
Author(s):  
Kelath Murali Manoj ◽  
Abhinav Parashar ◽  
Sudeep K. Gade ◽  
Avanthika Venkatachalam
Keyword(s):  
Cytochrome P450s ◽  
Microsomal Cytochrome ◽  
Metabolism Of Xenobiotics

Expression of hepatic microsomal cytochrome P450s as altered by uremia

1992 ◽  
Vol 43 (11) ◽  
pp. 2407-2412 ◽  
Author(s):  
Shinichi Ikemoto ◽  
Susumu Imaoka ◽  
Nobuyuki Hayahara ◽  
Masanobu Maekawa ◽  
Yoshihiko Funae
Keyword(s):  
Cytochrome P450s ◽  
Microsomal Cytochrome

P450 catalysed dehydrogenation

2017 ◽  
Vol 89 (6) ◽  
pp. 841-852 ◽  
Author(s):  
Siew Hoon Wong ◽  
Stephen G. Bell ◽  
James J. De Voss
Keyword(s):  
Valproic Acid ◽  
Direct Product ◽  
Vital Role ◽  
Cytochrome P450s ◽  
Catalysed Reaction ◽  
Endogenous Compounds ◽  
Oxidative Transformations ◽  
Metabolism Of Xenobiotics

Abstract Cytochrome P450s belong to a superfamily of enzymes that catalyse a wide variety of oxidative transformations. Hydroxylation is one the most thoroughly investigated of all identified P450-catalysed reactions whilst dehydrogenation has been relatively much less explored to date. P450-catalysed dehydrogenation is often found to occur with hydroxylation and thus, it was initially suspected to be a stepwise process consisting of hydroxylation and subsequent dehydration to yield the final olefin product. This theory has been proven to be invalid and the olefin was shown to be the direct product of a P450-catalysed reaction. This interesting reaction plays a vital role in the metabolism of xenobiotics and the biosynthesis of endogenous compounds, including a number of steroids. A number of well-known examples of P450 mediated dehydrogenation, including those in the metabolism of valproic acid, capsaicin and 3-methylindole and those in the biosynthesis of plant and fungal sterols are discussed in this review.

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