scholarly journals Untargeted Metabolomics Reveals Dose-Response Characteristics for Effect of Rhubarb in a Rat Model of Cholestasis

2016 ◽  
Vol 7 ◽  
Author(s):  
Cong-En Zhang ◽  
Ming Niu ◽  
Rui-Yu Li ◽  
Wu-Wen Feng ◽  
Xiao Ma ◽  
...  
Keyword(s):  
Dose Response ◽  
Rat Model ◽  
Untargeted Metabolomics ◽  
Response Characteristics

Dose-response characteristics of an amorphous silicon EPID

2005 ◽  
Vol 32 (10) ◽  
pp. 3095-3105 ◽  
Author(s):  
Peter Winkler ◽  
Alfred Hefner ◽  
Dietmar Georg
Keyword(s):  
Amorphous Silicon ◽  
Dose Response ◽  
Response Characteristics

Dose-response of vasopressin in a rat model of asphyxial cardiac arrest

2009 ◽  
Vol 27 (8) ◽  
pp. 935-941 ◽  
Author(s):  
Meng-Hua Chen ◽  
Feng-Qing Song ◽  
Lu Xie ◽  
Li-Ping Wang ◽  
Jun-Yu Lu ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Dose Response ◽  
Rat Model ◽  
Asphyxial Cardiac Arrest

A rat model of unilateral hindpaw burn injury: Slowly developing rightwards shift of the morphine dose–response curve

Pain ◽  
2005 ◽  
Vol 116 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Shuxing Wang ◽  
Grewo Lim ◽  
Liling Yang ◽  
Qing Zeng ◽  
Backil Sung ◽  
...  
Keyword(s):  
Dose Response ◽  
Rat Model ◽  
Response Curve ◽  
Burn Injury ◽  
Dose Response Curve ◽  
Morphine Dose

A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25751-25765 ◽  
Author(s):  
Xinyu Yu ◽  
Shanlei Qiao ◽  
Di Wang ◽  
Jiayong Dai ◽  
Jun Wang ◽  
...  
Keyword(s):  
Animal Model ◽  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Depressive Disorder ◽  
Rat Model ◽  
Untargeted Metabolomics ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Major Depressive ◽  
Metabolomics Study

An untargeted metabolomics study to investigate the metabolome change in plasma, hippocampus and prefrontal cortex (PFC) in an animal model with a major depressive disorder (MDD) had been conducted.

Varying dose–response characteristics of different immunoassays and an in-vitro bioassay for FSH are responsible for changing ratios of biologically active to immunologically active FSH

1990 ◽  
Vol 127 (3) ◽  
pp. 523-532 ◽  
Author(s):  
F. Jockenhövel ◽  
S. A. Khan ◽  
E. Nieschlag
Keyword(s):  
Sertoli Cell ◽  
Dose Response ◽  
Serum Levels ◽  
Biologically Active ◽  
Testicular Function ◽  
In Vitro Bioassay ◽  
Great Caution ◽  
Response Characteristics ◽  
Infertile Men

ABSTRACT Serum FSH levels in fertile and infertile men were determined by applying the Sertoli cell in-vitro bioassay and six different immunoassays. Bioassay and immunoassay estimates were significantly correlated (r ranging from 0·78 to 0·86; P<0·01). On average, all immunoassays measured lower FSH concentrations in samples with low FSH levels and higher FSH concentrations in those with high FSH levels compared with the bioassay. Ratios of bioactivity to immunoreactivity (B/I) were highest in fertile men and lowest in men with severe disturbances of testicular function. Depending on which immunoassay was used these differences were either significant or only marginal. Dose–response characteristics for WHO FSH standard preparation 78/549, used in the bioassay as well as in the immunoassays, were different between immunoassays and the bioassay, suggesting that decreasing B/I ratios with increasing FSH serum levels were method-related and reflected different slopes of the dose–response characteristics of the assays, rather than being true changes in the molecular composition of FSH. The present investigation underlines the necessity of choosing the immunoassay used for comparison with the bioassay carefully and of validating the system in regard to parallelism between dose–response characteristics. B/I ratios must be interpreted with great caution and previous studies which report changing B/I ratios in various endocrine situations may have to be reevaluated. Journal of Endocrinology (1990) 127, 523–532

scholarly journals Dose‐response relationship of human CD34+ cells in an athymic rat model of myocardial infarction

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Ben Brooks ◽  
Jeff McKee ◽  
Deborah Rice ◽  
Bernhard Baumgartner ◽  
Delara Motlagh ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Dose Response ◽  
Rat Model ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Human Cd34 ◽  
Cd34 Cells ◽  
Relationship Of
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