scholarly journals The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies

2015 ◽  
Vol 6 ◽  
Author(s):  
Hae J. Chon ◽  
Kyoung J. Bae ◽  
Yura Lee ◽  
Jiyeon Kim
Keyword(s):  
Hematological Malignancies ◽  
Casein Kinase ◽  
Casein Kinase 2 ◽  
Cancer Drug ◽  
Anti Cancer

Casein Kinase II: An attractive target for anti-cancer drug design

2010 ◽  
Vol 42 (10) ◽  
pp. 1602-1605 ◽  
Author(s):  
Ismail Muhamad Hanif ◽  
Ibrahim Muhammad Hanif ◽  
Muhammad Ali Shazib ◽  
Kashif Adil Ahmad ◽  
Shazib Pervaiz
Keyword(s):  
Drug Design ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Cancer Drug ◽  
Anti Cancer

scholarly journals RNA sequencing identified novel target genes for Adansonia digitata in breast and colon cancer cells

2021 ◽  
Vol 104 (3) ◽  
pp. 003685042110320
Author(s):  
Omar S. El-Masry ◽  
Arafat Goja ◽  
Mostafa Rateb ◽  
Amani Y Owaidah ◽  
Khaldoon Alsamman
Keyword(s):  
Ovarian Cancer ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Rna Sequencing ◽  
Casein Kinase ◽  
Casein Kinase 2 ◽  
Ovarian Cancer Cells ◽  
Adansonia Digitata ◽  
Anti Cancer ◽  
Mcf 7

Adansonia digitata exhibits numerous beneficial effects. In the current study, we investigated the anti-cancer effects of four different extracts of A. digitata (polar and non-polar extracts of fruit powder and fibers) on the proliferation of human colon cancer (HCT116), human breast cancer (MCF-7), and human ovarian cancer (OVCAR-3 and OVCAR-4) cell lines. RNA sequencing revealed the influence of the effective A. digitata fraction on the gene expression profiles of responsive cells. The results indicated that only the polar extract of the A. digitata fibers exhibited anti-proliferative activities against HCT116 and MCF-7 cells, but not ovarian cancer cells. Moreover, the polar extract of the fibers resulted in the modulation of the expression of multiple genes in HCT116 and MCF-7 cells. We propose that casein kinase 2 alpha 3 ( CSNK2A3) is a novel casein kinase 2 ( CSNK2) isoform in HCT116 cells and report, for the first time, the potential involvement of FYVE, RhoGEF, and PH domain-containing 3 ( FGD3) in colon cancer. Together, these findings provide evidence supporting the anti-cancer potential of the polar extract of A. digitata fibers in this experimental model of breast and colon cancers.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Psychogenic Mass Syndrome in Anti-Cancer Drug Exposure

2010 ◽  
Author(s):  
N. Magnavita ◽  
I. lavicoli ◽  
V. Leso ◽  
A. Bergamaschi
Keyword(s):  
Drug Exposure ◽  
Cancer Drug ◽  
Anti Cancer
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