scholarly journals Prenatal transplantation of mesenchymal stem cells to treat osteogenesis imperfecta

2014 ◽  
Vol 5 ◽  
Author(s):  
Jerry K. Y. Chan ◽  
Cecilia Götherström
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta

Gene expression profiling of bone marrow mesenchymal stem cells from Osteogenesis Imperfecta patients during osteoblast differentiation

2017 ◽  
Vol 60 (6) ◽  
pp. 326-334 ◽  
Author(s):  
Carla Martins Kaneto ◽  
Patrícia S. Pereira Lima ◽  
Karen Lima Prata ◽  
Jane Lima dos Santos ◽  
João Monteiro de Pina Neto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Osteoblast Differentiation ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Gene Targeting of Mutant COL1A2 Alleles in Mesenchymal Stem Cells From Individuals With Osteogenesis Imperfecta

2008 ◽  
Vol 16 (1) ◽  
pp. 187-193 ◽  
Author(s):  
Joel R Chamberlain ◽  
David R Deyle ◽  
Ulrike Schwarze ◽  
Peirong Wang ◽  
Roli K Hirata ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Gene Targeting

scholarly journals Upregulating CXCR4 in Human Fetal Mesenchymal Stem Cells Enhances Engraftment and Bone Mechanics in a Mouse Model of Osteogenesis Imperfecta

2011 ◽  
Vol 1 (1) ◽  
pp. 70-78 ◽  
Author(s):  
Gemma N. Jones ◽  
Dafni Moschidou ◽  
Kenneth Lay ◽  
Hassan Abdulrazzak ◽  
Maximilien Vanleene ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Bone Mechanics

Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice

Blood ◽  
2008 ◽  
Vol 111 (3) ◽  
pp. 1717-1725 ◽  
Author(s):  
Pascale V. Guillot ◽  
Oyebode Abass ◽  
J. H. Duncan Bassett ◽  
Sandra J. Shefelbine ◽  
George Bou-Gharios ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Bone Fractures ◽  
First Trimester ◽  
Long Bone ◽  
Structural Protein ◽  
Plate Height ◽  
Multiple Fractures ◽  
Donor Cells

Abstract The inherited skeletal dysplasia osteogenesis imperfecta (OI) results in multiple fractures and is currently treated empirically. We transplanted human first-trimester fetal blood mesenchymal stem cells (MSCs) into homozygous oim mice in utero. This resulted in a two-thirds reduction in long bone fractures (P < .01), with fewer fractures per mouse (median 1, range 0-2 in mice that received transplants vs median 3, range 1-5 in mice that did not receive transplants by 12 weeks, P < .01). Nearly all mice that did not receive transplants had fractures (47 [97.9%] of 48), in contrast to 17 (58.6%) of 29 4- to 12-week-old mice that received transplants (P < .01). Transplantation was associated with increased bone strength (P < .01), thickness (P < .01), and length (P < .01), and normalization/reduction of growth plate height in 4- to 12-week-old oim was reduced in mice that underwent transplantion (P < .001). More donor cells were found in bone tissues compared with other organs (P < .001), with cells clustered in areas of active bone formation and remodeling, and at sites of fracture healing. Donor cells found in the bone expressed osteoblast lineage genes, and produced the extracellular bone structural protein osteopontin. Finally, MSC transplantation decreased bone hydroxyproline content. In conclusion, intrauterine transplantation of fetal MSCs markedly reduced fracture rates and skeletal abnormalities in a mouse model of the intermediate severity type III OI, suggesting a scientific basis for MSC treatment of affected human fetuses.

scholarly journals Stakeholder views and attitudes towards prenatal and postnatal transplantation of fetal mesenchymal stem cells to treat Osteogenesis Imperfecta

2019 ◽  
Vol 27 (8) ◽  
pp. 1244-1253 ◽  
Author(s):  
Melissa Hill ◽  
Celine Lewis ◽  
Megan Riddington ◽  
Belinda Crowe ◽  
Catherine DeVile ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta ◽  
Stakeholder Views

Amelioration of osteogenesis in iPSC-derived mesenchymal stem cells from osteogenesis imperfecta patients by endoplasmic reticulum stress inhibitor

Life Sciences ◽  
2021 ◽  
pp. 119628
Author(s):  
Thitinat Duangchan ◽  
Tulyapruek Tawonsawatruk ◽  
Chanika Angsanuntsukh ◽  
Objoon Trachoo ◽  
Suradej Hongeng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Endoplasmic Reticulum Stress ◽  
Osteogenesis Imperfecta

scholarly journals Pre- and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta: A Two-Center Experience

2013 ◽  
Vol 3 (2) ◽  
pp. 255-264 ◽  
Author(s):  
Cecilia Götherström ◽  
Magnus Westgren ◽  
S.W. Steven Shaw ◽  
Eva Åström ◽  
Arijit Biswas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Osteogenesis Imperfecta
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