Selective Serotonin Reuptake Inhibitor Antidepressant Treatment Discontinuation Syndrome: A Review of the Clinical Evidence and the Possible Mechanisms Involved

Frontiers in Pharmacology ◽

10.3389/fphar.2013.00045 ◽

2013 ◽

Vol 4 ◽

Cited By ~ 34

Author(s):

Thibault Renoir

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Clinical Evidence ◽

Antidepressant Treatment ◽

Treatment Discontinuation ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

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SELECTIVE SEROTONIN REUPTAKE INHIBITOR DISCONTINUATION SYNDROME: THREE CASES PRESENTING TO A NEUROLOGIC PRACTICE

The Neurologist ◽

10.1097/00127893-200006060-00005 ◽

2000 ◽

Vol 6 (6) ◽

pp. 348-352

Author(s):

Rafael A. Rivas-Vazquez ◽

Enrique J. Carrazana ◽

Gustavo J. Rey ◽

Steve D. Wheeler

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

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Selective serotonin reuptake inhibitor discontinuation syndrome: A review

Advances in Therapy ◽

10.1007/bf02850015 ◽

2002 ◽

Vol 19 (1) ◽

pp. 17-26 ◽

Cited By ~ 41

Author(s):

Lut Tamam ◽

Nurgul Ozpoyraz

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

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Selective serotonin reuptake inhibitor discontinuation syndrome: Understanding, recognition, and management for psychologists.

Professional Psychology Research and Practice ◽

10.1037/0735-7028.30.5.464 ◽

1999 ◽

Vol 30 (5) ◽

pp. 464-469 ◽

Cited By ~ 5

Author(s):

Rafael A. Rivas-Vazquez ◽

Sheri L. Johnson ◽

Mark A. Blais ◽

Gustavo J. Rey

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

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Selective Serotonin Reuptake Inhibitor Discontinuation Syndrome

Journal of Psychosocial Nursing and Mental Health Services ◽

10.3928/0279-3695-20021201-10 ◽

2002 ◽

Vol 40 (12) ◽

pp. 14-18

Author(s):

Deborah L Finfgeld

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

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Biological and behavioural antidepressant treatment responses with the selective serotonin reuptake inhibitor fluoxetine can be determined by the environment

Molecular Psychiatry ◽

10.1038/mp.2017.68 ◽

2017 ◽

Vol 22 (4) ◽

pp. 484-484 ◽

Cited By ~ 2

Author(s):

A W Licinio ◽

M L Wong ◽

J Licinio

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Antidepressant Treatment ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Treatment Responses

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The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain — A translational model for postpartum depression

Hormones and Behavior ◽

10.1016/j.yhbeh.2015.05.005 ◽

2016 ◽

Vol 77 ◽

pp. 124-131 ◽

Cited By ~ 25

Author(s):

Achikam Haim ◽

Christopher Albin-Brooks ◽

Morgan Sherer ◽

Emily Mills ◽

Benedetta Leuner

Keyword(s):

Postpartum Depression ◽

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Antidepressant Treatment ◽

Structural Plasticity ◽

Selective Serotonin ◽

Translational Model ◽

Serotonin Reuptake Inhibitor ◽

Gestational Stress

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Is left stroke a risk-factor for selective serotonin reuptake inhibitor antidepressant treatment resistance?

Journal of Neurology ◽

10.1007/s00415-003-1023-2 ◽

2003 ◽

Vol 250 (4) ◽

pp. 449-455 ◽

Cited By ~ 20

Author(s):

Gianfranco Spalletta ◽

Giovanni Guida ◽

Carlo Caltagirone

Keyword(s):

Risk Factor ◽

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Antidepressant Treatment ◽

Treatment Resistance ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor

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Selective serotonin reuptake inhibitor discontinuation syndrome in children: Six case reports

Current Therapeutic Research ◽

10.1016/s0011-393x(02)80025-x ◽

2002 ◽

Vol 63 (3) ◽

pp. 188-197 ◽

Cited By ~ 6

Author(s):

Rasim Somer Diler ◽

Ayse Avci

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Case Reports ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

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Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized clinical trial

Biological Psychiatry ◽

10.1016/s0006-3223(98)00126-7 ◽

1998 ◽

Vol 44 (2) ◽

pp. 77-87 ◽

Cited By ~ 301

Author(s):

Jerrold F Rosenbaum ◽

Maurizio Fava ◽

Sharon L Hoog ◽

Richard C Ascroft ◽

William B Krebs

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

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Selective serotonin reuptake inhibitor ‘discontinuation syndrome’ or withdrawal

The British Journal of Psychiatry ◽

10.1192/bjp.2019.269 ◽

2020 ◽

pp. 1-4

Author(s):

Ivana Massabki ◽

Elia Abi-Jaoude

Keyword(s):

Selective Serotonin Reuptake Inhibitor ◽

Reuptake Inhibitor ◽

Serotonin Reuptake ◽

Selective Serotonin ◽

Serotonin Reuptake Inhibitor ◽

Discontinuation Syndrome

Summary Attempts to define selective serotonin reuptake inhibitor (SSRI) withdrawal with the term ‘discontinuation syndrome’ are not supported by evidence. Acknowledging that SSRI use can result in dependence and withdrawal allows patients to be better informed around decisions related to these drugs, and helps inform strategies for safe tapering as appropriate.

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