scholarly journals The SLC25A42 Transcript Is a Biomarker for Fetal Reprogramming in Response to Placental Insufficiency in Preterm Newborns Under 32 Weeks Gestation—A Pilot Study

2020 ◽  
Vol 8 ◽  
Author(s):  
Fu-Sheng Chou ◽  
Pei-Shan Wang
Keyword(s):  
Pilot Study ◽  
Placental Insufficiency ◽  
Fetal Reprogramming ◽  
Preterm Newborns

scholarly journals Quantifying Fetal Reprogramming for Biomarker Development in the Era of High-Throughput Sequencing

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 329
Author(s):  
Fu-Sheng Chou ◽  
Krystel Newton ◽  
Pei-Shan Wang
Keyword(s):  
High Throughput ◽  
High Throughput Sequencing ◽  
Well Being ◽  
Placental Insufficiency ◽  
Definitive Treatment ◽  
Optimal Timing ◽  
Hypertensive Disorders ◽  
Clinical Tools ◽  
Fetal Reprogramming ◽  
Offspring Health

Gestational hypertensive disorders continue to threaten the well-being of pregnant women and their offspring. The only current definitive treatment for gestational hypertensive disorders is delivery of the fetus. The optimal timing of delivery remains controversial. Currently, the available clinical tools do not allow for assessment of fetal stress in its early stages. Placental insufficiency and fetal growth restriction secondary to gestational hypertensive disorders have been shown to have long-term impacts on offspring health even into their adulthood, becoming one of the major focuses of research in the field of developmental origins of health and disease. Fetal reprogramming was introduced to describe the long-lasting effects of the toxic intrauterine environment on the growing fetus. With the advent of high-throughput sequencing, there have been major advances in research attempting to quantify fetal reprogramming. Moreover, genes that are found to be differentially expressed as a result of fetal reprogramming show promise in the development of transcriptional biomarkers for clinical use in detecting fetal response to placental insufficiency. In this review, we will review key pathophysiology in the development of placental insufficiency, existing literature on high-throughput sequencing in the study of fetal reprogramming, and considerations regarding research design from our own experience.

A1 A pilot study to assess the effects of biological sounds on preterm newborns

2012 ◽  
Vol 88 ◽  
pp. S101
Author(s):  
M. Vivalda ◽  
G. Dealessandri ◽  
M. Fringuelllino ◽  
G.B. Brero ◽  
P. Manzoni ◽  
...  
Keyword(s):  
Pilot Study ◽  
Preterm Newborns

Exome sequencing and pathway analysis for identification of genetic variability relevant for bronchopulmonary dysplasia (BPD) in preterm newborns: A pilot study

2015 ◽  
Vol 451 ◽  
pp. 39-45 ◽  
Author(s):  
Paola Carrera ◽  
Chiara Di Resta ◽  
Chiara Volonteri ◽  
Emanuela Castiglioni ◽  
Silvia Bonfiglio ◽  
...  
Keyword(s):  
Pilot Study ◽  
Genetic Variability ◽  
Exome Sequencing ◽  
Bronchopulmonary Dysplasia ◽  
Pathway Analysis ◽  
Preterm Newborns

Pilot study on criteria in cavity preparation-facts or artifacts?

1973 ◽  
Vol 37 (11) ◽  
pp. 27-31 ◽  
Author(s):  
G Salvendy ◽  
WM Hinton ◽  
GW Ferguson ◽  
PR Cunningham
Keyword(s):  
Pilot Study ◽  
Cavity Preparation

A Pilot Study of Early Storybook Reading With Babies With Hearing Loss

2019 ◽  
Vol 62 (9) ◽  
pp. 3397-3412
Author(s):  
Michelle I. Brown ◽  
David Trembath ◽  
Marleen F. Westerveld ◽  
Gail T. Gillon
Keyword(s):  
Hearing Loss ◽  
Pilot Study ◽  
Visual Analysis ◽  
Single Case ◽  
Eye Contact ◽  
Preliminary Evidence ◽  
Storybook Reading ◽  
Book Selection ◽  
Turn Taking ◽  
Parent Child

Purpose This pilot study explored the effectiveness of an early storybook reading (ESR) intervention for parents with babies with hearing loss (HL) for improving (a) parents' book selection skills, (b) parent–child eye contact, and (c) parent–child turn-taking. Advancing research into ESR, this study examined whether the benefits from an ESR intervention reported for babies without HL were also observed in babies with HL. Method Four mother–baby dyads participated in a multiple baseline single-case experimental design across behaviors. Treatment effects for parents' book selection skills, parent–child eye contact, and parent–child turn-taking were examined using visual analysis and Tau-U analysis. Results Statistically significant increases, with large to very large effect sizes, were observed for all 4 participants for parent–child eye contact and parent–child turn-taking. Limited improvements with ceiling effects were observed for parents' book selection skills. Conclusion The findings provide preliminary evidence for the effectiveness of an ESR intervention for babies with HL for promoting parent–child interactions through eye contact and turn-taking.

Sign in / Sign up

Export Citation Format

Share Document