scholarly journals The rs1051931 G>A Polymorphism in the PLA2G7 Gene Confers Resistance to Immunoglobulin Therapy in Kawasaki Disease in a Southern Chinese Population

2020 ◽  
Vol 8 ◽  
Author(s):  
Xueping Gu ◽  
Wenchun Lin ◽  
Yufen Xu ◽  
Di Che ◽  
Yaqian Tan ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Chinese Population ◽  
Immunoglobulin Therapy ◽  
Southern Chinese

scholarly journals The IL-1B Gene Polymorphisms rs16944 and rs1143627 Contribute to an Increased Risk of Coronary Artery Lesions in Southern Chinese Children with Kawasaki Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Lan Yan Fu ◽  
Xiantao Qiu ◽  
Qiu Lian Deng ◽  
Ping Huang ◽  
Lei Pi ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Healthy Children ◽  
Nucleotide Polymorphisms ◽  
Coronary Artery Lesions ◽  
Multicenter Studies ◽  
Southern Chinese ◽  
Increased Risk

Background. Kawasaki disease (KD) is a systemic form of self-limited vasculitis in children less than five years old, and the main complication is coronary artery injury. However, the etiology of KD remains unclear. The IL-1B polymorphisms rs16944 GG and rs1143627 AA and their diplotype GA/GA have been associated with significantly increased risk of intravenous immunoglobulin (IVIG) resistance in a Taiwanese population, but the relationship between rs16944 A/G and rs1143627 G/A and coronary artery lesions (CALs) in patients with KD has not been investigated. The present study is aimed at investigating whether the rs16944 A/G and rs1143627 G/A polymorphisms in IL-1B were associated with KD susceptibility and CALs in a southern Chinese population. Methods and Results. We recruited 719 patients with KD and 1401 healthy children. Multiplex PCR was used to assess the genotypes of single nucleotide polymorphisms (SNPs), including two SNPs of IL-1B, rs16944 A/G and rs1143627 G/A. According to the results, no significant association was observed between the IL-1B (rs16944 and rs1143627) polymorphisms and KD risk in the patients compared with the healthy controls in our southern Chinese population. However, in further stratified analysis, we found that children younger than 12 months with the rs16944 GG and rs1143627 AA genotypes of IL-1B had a higher risk of CALs than those with the AA/AG genotypes of rs16944 and GG/AG genotypes of rs1143627 (OR=2.28, 95% CI=1.32-3.95, P=0.0032, adjusted OR=2.33, 95% CI=1.34-4.04, P=0.0027). Conclusions. Our results indicated that there was no association between the rs16944 A/G and rs1143627 G/A gene polymorphisms and KD susceptibility. However, the rs16944 GG and rs1143627 AA genotypes of IL-1B may significantly impact the risk of CAL formation in children younger than 12 months, which may contribute to the pathogenesis of KD. These findings need further validation in multicenter studies with larger sample sizes.

scholarly journals ABCC4 Variants Modify Susceptibility to Kawasaki Disease in a Southern Chinese Population

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Di Che ◽  
Lei Pi ◽  
Zhenzhen Fang ◽  
Yufen Xu ◽  
Minmin Cai ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Chinese Population ◽  
Linkage Study ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Ethnic Populations ◽  
Southern Chinese ◽  
Increased Risk ◽  
Variant Genotype ◽  
Family Based

A previous family-based linkage study revealed that Kawasaki disease (KD) was associated with variations of the ATP-binding cassette subfamily C member 4 (ABCC4) gene in most European populations. However, significant differences exist among ethnic populations in European and Chinese subjects; therefore, whether ABCC4 variants indicate susceptibility to KD in Chinese children is unclear. The purpose of this research was to evaluate correlations between ABCC4 gene polymorphisms and susceptibility to KD in a Southern Chinese population. We genotyped six polymorphisms (rs7986087, rs868853, rs3765534, rs1751034, rs3742106, and rs9561778) in 775 KD patients and 774 healthy controls. Ninety-five percent confidence intervals (95% CIs) and odds ratios (ORs) were used to assess the strength of each association. We found that the rs7986087 T variant genotype was associated with significantly higher susceptibility to KD (adjusted OR = 1.30, 95% CI = 1.05–1.60 for rs7986087 CT/TT). However, the rs868853 T variant genotype was associated with significantly lower susceptibility to KD (adjusted OR = 0.74, 95% CI = 0.59–0.92 for rs868853 CT/CC). Compared with the patients with 0–4 ABCC4 risk genotypes, the patients with 5-6 ABCC4 risk genotypes had a significantly increased risk of KD (adjusted OR = 1.63, 95% CI = 1.07–2.47), and this risk was more significant in the subgroups of females, subjects aged 12–60 months, and individuals with coronary artery lesions. These results indicate that specific single-nucleotide polymorphisms in the ABCC4 gene may increase susceptibility to KD in a Southern Chinese population.

scholarly journals The association between the miR-146a rs2910164 C>G polymorphism and Kawasaki disease in a southern Chinese population

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Li Zhang ◽  
Jinxin Wang ◽  
Di Che ◽  
Yanfei Wang ◽  
Xing Rong ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Chinese Population ◽  
Inflammatory Responses ◽  
Disease Risk ◽  
Critical Role ◽  
Vascular Endothelial ◽  
Multicenter Studies ◽  
Southern Chinese ◽  
Immune Mediated ◽  
Stratified Analysis

miR-146a plays a critical role in innate immune and inflammatory responses. Kawasaki disease involves immune-mediated inflammatory responses, which leads to vascular endothelial injury. However, there has been no study on the association between the miR-146a rs2910164 C>G polymorphism and Kawasaki disease risk. We enrolled 532 Kawasaki disease patients and 623 healthy controls from southern Chinese population, and the miR-146a rs2910164 C>G polymorphism was genotyped by the TaqMan method. There was no evidence that this polymorphism was associated with Kawasaki disease. Stratified analysis also showed no significant association. The present study indicates that the miR-146a rs2910164 C>G polymorphism may not be associated with Kawasaki disease in the southern Chinese population. Larger multicenter studies are needed to confirm our conclusions.

scholarly journals The rs1625579 T>G polymorphism in the miRNA-137 gene confers a risk of early-onset Kawasaki disease in a southern Chinese population

2018 ◽  
Vol Volume 11 ◽  
pp. 1055-1060 ◽  
Author(s):  
Di Che ◽  
Jiawen Li ◽  
Lanyan Fu ◽  
Lei Pi ◽  
Xing Rong ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Early Onset ◽  
Chinese Population ◽  
Southern Chinese ◽  
Em Gene
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