scholarly journals Association Between Lactates, Blood Glucose, and Systemic Oxygen Delivery in Children After Cardiopulmonary Bypass

2020 ◽  
Vol 8 ◽  
Author(s):  
Philippe Klee ◽  
Peter C. Rimensberger ◽  
Oliver Karam
Keyword(s):  
Blood Glucose ◽  
Cardiopulmonary Bypass ◽  
Oxygen Delivery ◽  
Systemic Oxygen Delivery ◽  
Systemic Oxygen

Gastric Mucosal Oxygen Delivery Decreases During Cardiopulmonary Bypass Despite Constant Systemic Oxygen Delivery

1998 ◽  
Vol 86 (3) ◽  
pp. 455-460 ◽  
Author(s):  
Jean-Charles Sicsic ◽  
Jacques Duranteau ◽  
Herve Corbineau ◽  
Sami Antoun ◽  
Pascal Menestret ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Oxygen Delivery ◽  
Systemic Oxygen Delivery ◽  
Systemic Oxygen

Gastric Mucosal Oxygen Delivery Decreases During Cardiopulmonary Bypass Despite Constant Systemic Oxygen Delivery

1998 ◽  
Vol 86 (3) ◽  
pp. 455-460 ◽  
Author(s):  
Jean-Charles Sicsic ◽  
Jacques Duranteau ◽  
Herve Corbineau ◽  
Sami Antoun ◽  
Pascal Menestret ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Oxygen Delivery ◽  
Systemic Oxygen Delivery ◽  
Systemic Oxygen

Measurement of inotropy and systemic oxygen delivery in term, low- and very-low-birth-weight neonates using the Ultrasonic Cardiac Output Monitor (USCOM)

2020 ◽  
Vol 48 (3) ◽  
pp. 289-295
Author(s):  
Man-Li Zheng ◽  
Shao-Ru He ◽  
Yu-Mei Liu ◽  
Lin Chen
Keyword(s):  
Cardiac Output ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pulse Oximetry ◽  
Oxygen Delivery ◽  
Very Low Birth Weight ◽  
Hemoglobin Concentration ◽  
Systemic Oxygen Delivery ◽  
Systemic Oxygen ◽  
Cardiac Output Monitor

AbstractBackgroundThe aim of this study was to assess the normal values of the Smith-Madigan inotropy index (SMII) and oxygen delivery index (DO2I) in low-birth-weight (LBW) and very-low-birth-weight (VLBW) newborns on the first 3 days of life, and to identify how different degrees of maturity influence cardiovascular alterations during the transitional period compared with term neonates.MethodsTwenty-eight VLBW newborns, 46 LBW newborns and 50 normal full-term newborns admitted to our department were studied. Hemodynamics of the left heart were measured in all neonates over the first 3 days using the Ultrasonic Cardiac Output Monitor (USCOM). This was combined with hemoglobin concentration and pulse oximetry to calculate DO2I. Blood pressure was combined with the hemodynamic measures and hemoglobin concentration to calculate SMII.ResultsSMII showed statistically significant differences among the three groups (VLBW 0.48 ± 0.11; LBW 0.54 ± 0.13; term 0.69 ± 0.17 W/m2 P < 0.001), which was in line with the following myocardial parameters: stroke volume index (SVI) and cardiac index (CI) (P < 0.001 and <0.001). For systemic oxygen delivery (DO2) parameters, significant differences were found for DO2I (P < 0.001) while hemoglobin concentration and pulse oximetry demonstrated no significant differences. In the VLBW group, SMII and DO2I showed no significant change over the 3 days.ConclusionNormal inotropy and systemic DO2I values in VLBW neonates over the first 3 days of life were assessed. SMII and DO2I were significantly lower in VLBW neonates during the first 72 h of life. With increasing birth weight, higher myocardial inotropy and DO2 were found. The addition of USCOM examination to standard neonatal echocardiography may provide further important information regarding cardiac function.

Hyperglycaemia is negatively associated with systemic and cerebral oxygen transport in neonates after the Norwood procedure

2011 ◽  
Vol 22 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Gencheng Zhang ◽  
Sally Cai ◽  
Jia Li
Keyword(s):  
Cardiac Output ◽  
Oxygen Consumption ◽  
Blood Glucose ◽  
Cardiopulmonary Bypass ◽  
Oxygen Transport ◽  
Norwood Procedure ◽  
Cerebral Oxygen ◽  
Tight Glucose Control ◽  
Oxygen Extraction Ratio ◽  
Systemic Oxygen

AbstractObjectiveHyperglycaemia has been identified as a risk factor for adverse outcomes in critically ill patients, including those who have undergone cardiopulmonary bypass. Tight glucose control with insulin therapy has been shown to improve outcomes, but is not common practice for children following cardiopulmonary bypass. We examined the relationship between blood glucose level and systemic and cerebral oxygen transport in a uniform group of neonates after the Norwood procedure.MethodsSystemic oxygen consumption was measured using respiratory mass spectrometry in 17 neonates for 72 hours postoperatively. Cardiac output, systemic and total pulmonary vascular resistances – including the Blalock–Taussig shunt, systemic oxygen delivery and oxygen extraction ratio, as well as arterial lactate and glucose, were measured at 2- to 4-hour intervals. Cerebral oxygen saturation was measured by near-infrared spectroscopy.ResultsBlood glucose levels ranged from 2.8 to 24.6 millimoles per litre. Elevated glucose level showed a significant negative correlation with cardiac output (p = 0.02) and cerebral oxygen saturation (p = 0.03), and a positive correlation with oxygen extraction ratio (p = 0.03). It tended to correlate positively with systemic vascular resistance (p = 0.09) and negatively with oxygen delivery (p = 0.09), but did not correlate with oxygen consumption (p = 0.13).ConclusionsHyperglycaemia is negatively associated with systemic haemodynamics, oxygen transport, and cerebral oxygenation status in neonates after the Norwood procedure. Further study is warranted to examine tight glucose control with insulin therapy on postoperative systemic and cerebral oxygen transport and functional outcomes in neonates after cardiopulmonary bypass.

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