scholarly journals Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea

2020 ◽  
Vol 8 ◽  
Author(s):  
Olubukola T. Idoko ◽  
Kinga K. Smolen ◽  
Oghenebrume Wariri ◽  
Abdulazeez Imam ◽  
Casey P. Shannon ◽  
...  
Keyword(s):  
Cohort Study ◽  
Systems Biology ◽  
Papua New Guinea ◽  
Newborn Infants ◽  
New Guinea ◽  
The Gambia ◽  
Longitudinal Cohort Study ◽  
Clinical Protocol ◽  
Longitudinal Cohort ◽  
Vaccine Immunogenicity

scholarly journals Epilepsy in children in Papua New Guinea: a longitudinal cohort study

2019 ◽  
Author(s):  
Casparia Mond ◽  
John D Vince ◽  
Trevor Duke
Keyword(s):  
Cohort Study ◽  
Papua New Guinea ◽  
Low Income ◽  
Seizure Control ◽  
New Guinea ◽  
Longitudinal Cohort Study ◽  
Seizure Type ◽  
Treatment Access ◽  
Longitudinal Cohort ◽  
Children And Parents

AbstractBackgroundEpilepsy affects up to 1-4% of children living in low income and middle countries, however there are few studies of the problems faced by children with epilepsy in such settings.AimTo document the characteristics and situation for children with epilepsy in Port Moresby, an urban area in Papua New Guinea, a low-middle income country in the Western Pacific region. To describe the types of epilepsy, associated comorbidities, treatment access and barriers, the adequacy of seizure control, the quality of life and developmental opportunities, and the difficulties faced by children with epilepsy and their families.MethodsA longitudinal cohort study, following children with epilepsy over 18-24 months. Mixed methods evaluations included assessments of seizure control, medications, neurodevelopment, and structured interviews with children and parents, and a parent-diary to record additional information.ResultsForty-seven children with epilepsy were followed for a median of 18 months; 75% were being treated with phenobarbitone. Seizure control improved over time for some children, but inconsistent supply of phenobarbitone hindered better control. Twenty six (55%) children had some developmental delay. Children gave vivid descriptions of their experience of seizures. Most children and parents had a positive view of the future but faced many challenges including financial difficulties, fear of seizures especially at school, restriction of activity and stigma and discrimination.ConclusionComprehensive care for children with epilepsy requires a good knowledge of the individual patient - including their seizure type and comorbidities, their family, and their strengths and vulnerabilities. It requires long term follow up, with a dedicated team of health professionals to provide support.

scholarly journals Epilepsy in Papua New Guinea: a longitudinal cohort study

2019 ◽  
Vol 104 (10) ◽  
pp. 941-946 ◽  
Author(s):  
Casparia Mond ◽  
Trevor Duke ◽  
John Vince
Keyword(s):  
Cohort Study ◽  
Papua New Guinea ◽  
Low Income ◽  
Seizure Control ◽  
New Guinea ◽  
Longitudinal Cohort Study ◽  
Seizure Type ◽  
Structured Interviews ◽  
Longitudinal Cohort ◽  
Children And Parents

Epilepsy affects up to 1-4% of children living in low income and middle countries, however there are few studies of the problems faced by children with epilepsy in such settings. We aimed to document the situation for children with epilepsy in Port Moresby, an urban area in Papua New Guinea, a low-middle income country in the Western Pacific region. We conducted longitudinal cohort study using mixed methods, with serial data collected over 2 years which assessed seizure control, neurodevelopment, and structured interviews with children and parents. For quantitative data descriptive statistics are reported; for qualitative data common responses, themes, experiences and perceptions were grouped and reported in narrative. Forty-seven children with epilepsy were followed for a median of 18 months. Twenty six (55%) children had some associated neurodevelopmental disability. Children gave detailed and vivid descriptions of their experience of seizures. Most children and parents had a positive view of the future but faced many challenges including financial difficulties, fear of having seizures especially at school, restriction of activity that isolated them from peers, and significant stigma and discrimination. Seizure control improved over time for some children, but inconsistent supply of phenobarbitone hindered better control. Comprehensive care for children with epilepsy requires a good knowledge of the individual patient —including their seizure type and comorbidities, their family, and their strengths and vulnerabilities. Children with epilepsy face many problems that can lead to isolation, discrimination and restricted opportunities.

2453-PUB: Changes in Metabolic Syndrome and Diabetes Risk: A Nationwide Longitudinal Cohort Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2453-PUB
Author(s):  
MIN-KYUNG LEE ◽  
HYUK-SANG KWON ◽  
KI-HO SONG ◽  
JAE HYUK LEE
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Diabetes Risk ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort
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