scholarly journals The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT

2019 ◽  
Vol 7 ◽  
Author(s):  
Shahrzad Bakhtiar ◽  
Bella Shadur ◽  
Polina Stepensky
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Working Party ◽  
Inborn Errors ◽  
Hematopoietic Stem ◽  
Comprehensive Review ◽  
Party Group

scholarly journals β3-Adrenoreceptors as ROS Balancer in Hematopoietic Stem Cell Transplantation

2021 ◽  
Vol 22 (6) ◽  
pp. 2835
Author(s):  
Amada Pasha ◽  
Maura Calvani ◽  
Claudio Favre
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Therapeutic Potential ◽  
Redox Homeostasis ◽  
Primary Role ◽  
Inborn Errors ◽  
Hematopoietic Stem

In the last decades, the therapeutic potential of hematopoietic stem cell transplantation (HSCT) has acquired a primary role in the management of a broad spectrum of diseases including cancer, hematologic conditions, immune system dysregulations, and inborn errors of metabolism. The different types of HSCT, autologous and allogeneic, include risks of severe complications including acute and chronic graft-versus-host disease (GvHD) complications, hepatic veno-occlusive disease, lung injury, and infections. Despite being a dangerous procedure, it improved patient survival. Hence, its use was extended to treat autoimmune diseases, metabolic disorders, malignant infantile disorders, and hereditary skeletal dysplasia. HSCT is performed to restore or treat various congenital conditions in which immunologic functions are compromised, for instance, by chemo- and radiotherapy, and involves the administration of hematopoietic stem cells (HSCs) in patients with depleted or dysfunctional bone marrow (BM). Since HSCs biology is tightly regulated by oxidative stress (OS), the control of reactive oxygen species (ROS) levels is important to maintain their self-renewal capacity. In quiescent HSCs, low ROS levels are essential for stemness maintenance; however, physiological ROS levels promote HSC proliferation and differentiation. High ROS levels are mainly involved in short-term repopulation, whereas low ROS levels are associated with long-term repopulating ability. In this review, we aim summarize the current state of knowledge about the role of β3-adrenoreceptors (β3-ARs) in regulating HSCs redox homeostasis. β3-ARs play a major role in regulating stromal cell differentiation, and the antagonist SR59230A promotes differentiation of different progenitor cells in hematopoietic tumors, suggesting that β3-ARs agonism and antagonism could be exploited for clinical benefit.

Hematopoietic stem cell transplantation and acute kidney injury in children: A comprehensive review

2017 ◽  
Vol 21 (4) ◽  
pp. e12935 ◽  
Author(s):  
Rupesh Raina ◽  
Nicholas Herrera ◽  
Vinod Krishnappa ◽  
Sidharth Kumar Sethi ◽  
Akash Deep ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Kidney Injury ◽  
Hematopoietic Stem ◽  
Comprehensive Review
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