scholarly journals Epstein-Barr Virus Induced Gene-2 Upregulation Identifies a Particular Subtype of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

2019 ◽  
Vol 7 ◽  
Author(s):  
Jonathan R. Kerr
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Epstein Barr Virus ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Epstein Barr

scholarly journals Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Manuel Ruiz-Pablos ◽  
Bruno Paiva ◽  
Rosario Montero-Mateo ◽  
Nicolas Garcia ◽  
Aintzane Zabaleta
Keyword(s):  
T Cell ◽  
Chronic Fatigue Syndrome ◽  
Epstein Barr Virus ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Th2 Response ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Cell Immunity ◽  
Epstein Barr

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) affects approximately 1% of the general population. It is a chronic, disabling, multi-system disease for which there is no effective treatment. This is probably related to the limited knowledge about its origin. Here, we summarized the current knowledge about the pathogenesis of ME/CFS and revisit the immunopathobiology of Epstein-Barr virus (EBV) infection. Given the similarities between EBV-associated autoimmune diseases and cancer in terms of poor T cell surveillance of cells with EBV latency, expanded EBV-infected cells in peripheral blood and increased antibodies against EBV, we hypothesize that there could be a common etiology generated by cells with EBV latency that escape immune surveillance. Albeit inconclusive, multiple studies in patients with ME/CFS have suggested an altered cellular immunity and augmented Th2 response that could result from mechanisms of evasion to some pathogens such as EBV, which has been identified as a risk factor in a subset of ME/CFS patients. Namely, cells with latency may evade the immune system in individuals with genetic predisposition to develop ME/CFS and in consequence, there could be poor CD4 T cell immunity to mitogens and other specific antigens, as it has been described in some individuals. Ultimately, we hypothesize that within ME/CFS there is a subgroup of patients with DRB1 and DQB1 alleles that could confer greater susceptibility to EBV, where immune evasion mechanisms generated by cells with latency induce immunodeficiency. Accordingly, we propose new endeavors to investigate if anti-EBV therapies could be effective in selected ME/CFS patients.

scholarly journals Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 185
Author(s):  
Maria Eugenia Ariza
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Disease Process ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Specific Proteins ◽  
Epstein Barr ◽  
Human Herpesviruses

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Systemic Exertion Intolerance Disease (SEID) is a chronic multisystem illness of unconfirmed etiology. There are currently no biomarkers and/or signatures available to assist in the diagnosis of the syndrome and while numerous mechanisms have been hypothesized to explain the pathology of ME/CFS, the triggers and/or drivers remain unknown. Initial studies suggested a potential role of the human herpesviruses especially Epstein-Barr virus (EBV) in the disease process but inconsistent and conflicting data led to the erroneous suggestion that these viruses had no role in the syndrome. New studies using more advanced approaches have now demonstrated that specific proteins encoded by EBV could contribute to the immune and neurological abnormalities exhibited by a subgroup of patients with ME/CFS. Elucidating the role of these herpesvirus proteins in ME/CFS may lead to the identification of specific biomarkers and the development of novel therapeutics.

Post Viral Chronic Fatigue Syndrome: Persistence of Epstein-Barr Virus DNA in Muscle

1989 ◽  
pp. 439-444
Author(s):  
Leonard C. Archard ◽  
John L. Peters ◽  
Peter O. Behan ◽  
David Doyle ◽  
Michael Mackett ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Epstein Barr Virus ◽  
Chronic Fatigue ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Epstein Barr

Antibody Responses to Epstein-Barr Virus, Human Herpesvirus 6 and Human Herpesvirus 7 in Patients with Chronic Fatigue Syndrome

Intervirology ◽  
1995 ◽  
Vol 38 (5) ◽  
pp. 269-273 ◽  
Author(s):  
Takeshi Sairenji ◽  
Koichi Yamanishi ◽  
Yoichi Tachibana ◽  
Giuseppe Bertoni ◽  
Takeshi Kurata
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Chronic Fatigue ◽  
Antibody Responses ◽  
Human Herpesvirus 6 ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Herpesvirus 6 ◽  
Epstein Barr

Stress-associated changes in the steady-state expression of latent Epstein–Barr virus: Implications for chronic fatigue syndrome and cancer

2005 ◽  
Vol 19 (2) ◽  
pp. 91-103 ◽  
Author(s):  
Ronald Glaser ◽  
David A. Padgett ◽  
Monica L. Litsky ◽  
Robert A. Baiocchi ◽  
Eric V. Yang ◽  
...  
Keyword(s):  
Steady State ◽  
Chronic Fatigue Syndrome ◽  
Epstein Barr Virus ◽  
Chronic Fatigue ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Epstein Barr

scholarly journals Response to valganciclovir in chronic fatigue syndrome patients with human herpesvirus 6 and Epstein-Barr virus IgG antibody titers

2012 ◽  
Vol 84 (12) ◽  
pp. 1967-1974 ◽  
Author(s):  
Tessa Watt ◽  
Stephanie Oberfoell ◽  
Raymond Balise ◽  
Mitchell R. Lunn ◽  
Aroop K. Kar ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Epstein Barr Virus ◽  
Human Herpesvirus ◽  
Chronic Fatigue ◽  
Human Herpesvirus 6 ◽  
Igg Antibody ◽  
Barr Virus ◽  
Fatigue Syndrome ◽  
Antibody Titers ◽  
Epstein Barr
Sign in / Sign up

Export Citation Format

Share Document