scholarly journals Modeling How Heterogeneity in Cell Cycle Length Affects Cancer Cell Growth Dynamics in Response to Treatment

2020 ◽  
Vol 10 ◽  
Author(s):  
Eleftheria Tzamali ◽  
Georgios Tzedakis ◽  
Vangelis Sakkalis
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cycle Length ◽  
Growth Dynamics ◽  
Response To Treatment ◽  
Cancer Cell Growth ◽  
Cell Cycle Length

scholarly journals ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis

2016 ◽  
Vol 7 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Xingjie Ma ◽  
Minlu Huang ◽  
Zhenqiang Wang ◽  
Bingya Liu ◽  
Zhenggang Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals MicroRNA-203 Regulates Growth and Metastasis of Breast Cancer

2015 ◽  
Vol 37 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Shan Zhao ◽  
Jinzhu Han ◽  
Likang Zheng ◽  
Zixin Yang ◽  
Li Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

Backgrounds/Aims: MicroRNAs (MiRNAs) control many biological events and play critical roles in the development of tumor. Among all miRNAs, miR203 has been recently shown to have an inhibitory effect on prostate cancer. However, its involvement in the carcinogenesis of breast cancer has not been reported. Methods: We examined the levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. We also examined the levels of miR203 in several commonly used breast cancer cell lines. The effects of overexpression or depletion of miR203 on breast cancer cell growth were analyzed by a MTT assay, and on breast cancer cell invasion were examined by a scratch wound healing assay and a transwell cell migration assay. MiR203-targeted genes were analyzed by Western blot. Results: We detected significantly lower levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. Moreover, the levels of miR203 were significantly lower in breast cancer tissue from the patients with cancer metastasis. Decreased miR203 levels were detected in all examined breast cancer lines. Overexpression of miR203 inhibited breast cancer cell growth and invasion, while antisense-mediated inhibition of miR203 enhanced cancer cell growth and invasion. Further analyses show that miR203 may inhibit cell growth through decreasing cell-cycle activator cyclinD2 and CDK6, increasing cell-cycle suppressor p21 and p27, and increasing apoptosis-associated protein Bcl-2. MiR203 may also inhibit cell metastasis through suppressing matrix metalloproteinase 2 (MMP2), MMP7 and MMP9. Conclusion: Our data thus highlight miR203 as a novel therapeutic target for breast cancer.

A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest

2006 ◽  
Vol 340 (4) ◽  
pp. 1224-1228 ◽  
Author(s):  
Michael B. Ujiki ◽  
Ben Milam ◽  
Xian-Zhong Ding ◽  
Alexandra B. Roginsky ◽  
M. Reza Salabat ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest

Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G2/M cell cycle arrest

2008 ◽  
Vol 120 (3) ◽  
pp. 394-401 ◽  
Author(s):  
Shih-Chung Hsu ◽  
Chien-Chih Ou ◽  
Jhy-Wei Li ◽  
Tzu-Chao Chuang ◽  
Han-Pon Kuo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
M Cell ◽  
Cancer Cell Growth ◽  
Cycle Arrest

scholarly journals ICT1 knockdown inhibits breast cancer cell growth via induction of cell cycle arrest and apoptosis

2017 ◽  
Vol 39 (4) ◽  
pp. 1037-1045 ◽  
Author(s):  
Chen Wang ◽  
Chenlu Liang ◽  
Weiliang Feng ◽  
Xianghou Xia ◽  
Feng Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Cycle Arrest
Sign in / Sign up

Export Citation Format

Share Document