scholarly journals Co-incidence of Human Papillomaviruses and Epstein–Barr Virus Is Associated With High to Intermediate Tumor Grade in Human Head and Neck Cancer in Syria

2020 ◽  
Vol 10 ◽  
Author(s):  
Ishita Gupta ◽  
Lina Ghabreau ◽  
Hamda Al-Thawadi ◽  
Amber Yasmeen ◽  
Semir Vranic ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Human Head ◽  
Tumor Grade ◽  
Human Papillomaviruses ◽  
Barr Virus ◽  
Epstein Barr

Head and neck cancer in patients with human immunodeficiency virus-1 infection: incidence, outcome and association with Epstein-Barr virus

2004 ◽  
Vol 118 (3) ◽  
pp. 207-212 ◽  
Author(s):  
T. Powles ◽  
J. Powles ◽  
M. Nelson ◽  
A. Sandison ◽  
D. Peston ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Clinical Features ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Human Immunodeficiency Virus 1

Head and neck cancers have been described in patients with human immunodeficiency virus-1 (HIV-1) infection. However the incidence, aetiology and clinical features of the disease remain unclear.Patients with head and neck cancer and HIV were identified from a large HIV centre. The incidence and clinical features were recorded, and the tumours were stained for Epstein-Barr virus (EBV).Head and neckcancer occurred more frequently than in an age-matched control group (1.66 vs 0.55/10,000 patient years respectively p < 0.05). Highly active anti-retroviral therapy has not significantly altered the incidence of the disease. All of the tumours tested were positive for EBV. Patients were moderately immunosuppressed at diagnosis and had aggressive tumours. All but one of the patients died of cancer with a median survival of 28 months.Head and neck cancer occurs more frequently in HIV. It is an aggressive disease and EBV may play a role in its pathogenesis.

Epstein-barr virus (EBV) antibody in patients treated by radical radiotherapy for head and neck cancer

1978 ◽  
Vol 10 (5) ◽  
pp. 457-463 ◽  
Author(s):  
Marlene R. Halili ◽  
Ilya Spigland ◽  
Nan Foster ◽  
Nemetallah A. Ghossein
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Radical Radiotherapy ◽  
Barr Virus ◽  
Epstein Barr

Epstein-Barr Virus in Head and Neck Cancer Assessed by Quantitative Polymerase Chain Reaction

2004 ◽  
Vol 114 (6) ◽  
pp. 1027-1031 ◽  
Author(s):  
David Goldenberg ◽  
Nicole E. Benoit ◽  
Shahnaz Begum ◽  
William H. Westra ◽  
Yoram Cohen ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Epstein Barr Virus ◽  
Quantitative Polymerase Chain Reaction ◽  
Chain Reaction ◽  
Barr Virus ◽  
Polymerase Chain ◽  
Epstein Barr

scholarly journals Biomarkers for Cancers of the Head and Neck

2008 ◽  
Vol 1 ◽  
pp. CMENT.S1051 ◽  
Author(s):  
Viviana P. Lutzky ◽  
Denis J. Moss ◽  
David Chin ◽  
William B. Coman ◽  
Peter G. Parsons ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Strong Association ◽  
Human Head ◽  
Diagnostic Tools ◽  
Proteomic Profiling ◽  
Serum Samples ◽  
Barr Virus ◽  
New Biomarkers

Head and neck cancer is a broad term used to describe malignancies that arise in the nasal and oral cavities, pharynx and larynx, as well as the paranasal sinuses. Head and neck squamous cell carcinoma (HNSCC) affects the squamous epithelium of the oral cavity, tongue and oropharynx, excluding the nasopharynx. Recent advances in molecular technology, including gene expression and proteomic profiling appear to offer the potential for the development of specific biomarkers including diagnostic tools which may act as an aid to guide therapy for this malignancy. The other human head and neck cancer included in this review, nasopharyngeal carcinoma (NPC) is a malignancy derived from the undifferentiated epithelium of the nasopharyngeal cavity, and is considered here as a separate entity because its strong association with Epstein-Barr virus (EBV) presents the opportunity for the development of virus related and unrelated biomarkers. In particular, IgA antibodies to EBV and high levels of EBV DNA in serum samples of NPC patients have been recorded. This review aims to summarize some current and also potential new biomarkers that could be used for screening, diagnosis, monitoring and prognostic prediction for cancers of the head and neck, including NPC and HNSCC.

scholarly journals High-risk human papillomaviruses and Epstein–Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Karim Nagi ◽  
Ishita Gupta ◽  
Nawaf Jurdi ◽  
Ayesha Jabeen ◽  
Amber Yasmeen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Tissue Microarray ◽  
Epstein Barr Virus ◽  
Tumor Grade ◽  
Human Papillomaviruses ◽  
Breast Cancers ◽  
Human Breast ◽  
Barr Virus ◽  
Epstein Barr

Abstract Background High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein–Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as head and neck; in parallel, it has been recently pointed out that these oncoviruses can be detected in human breast cancers. Thus, we herein explored the presence/co-presence of high-risk HPVs and EBV in breast cancer in Lebanese women. Methods A cohort of 102 breast cancer samples and 14 normal breast tissues were assessed for the presence of HPVs and EBV. Polymerase chain reaction (PCR) and immunohistochemistry (IHC) analysis in addition to tissue microarray (TMA) platform were used in this study. Results We found the presence of HPV in 66/102 (65%) of our samples, while EBV is present in 41/102 (40%) of the cohort. Additionally, our data showed that high-risk HPV types (52, 35, 58, 45, 16 and 51) are the most frequent in breast cancer in Lebanese women. Meanwhile, we report that high-risk HPVs and EBV are co-present in 30/102 (29%) of the samples; more significantly, our results indicate that their co-presence is associated with tumor grade (p = 0.03). Conclusion Our data revealed that HPVs and EBV are present/co-present in human breast cancer where they may play an important role in its development and/or progression; thus, we believe that further investigations are essential to confirm and elucidate the presence/co-presence of these oncoviruses and the underlying mechanisms of their interaction in breast carcinogenesis.

scholarly journals High-Risk Human Papillomavirus and Epstein–Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis

Biology ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1232
Author(s):  
Rancés Blanco ◽  
Diego Carrillo-Beltrán ◽  
Alejandro H. Corvalán ◽  
Francisco Aguayo
Keyword(s):  
High Risk ◽  
Head And Neck ◽  
Tobacco Smoke ◽  
Epstein Barr Virus ◽  
Potential Role ◽  
Human Papillomaviruses ◽  
Oral Epithelium ◽  
Oncogenic Viruses ◽  
Barr Virus ◽  
Epstein Barr

High-risk human papillomaviruses (HR-HPVs) and Epstein–Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.

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