scholarly journals Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis

2020 ◽  
Vol 10 ◽  
Author(s):  
Aishe Dun ◽  
Xuan Zhao ◽  
Xu Jin ◽  
Tao Wei ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Risk ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work

scholarly journals Corrigendum: Association Between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis

2020 ◽  
Vol 10 ◽  
Author(s):  
Aishe Dun ◽  
Xuan Zhao ◽  
Xu Jin ◽  
Tao Wei ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Risk ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work

Association between Night-Shift-Work and Level of Melatonin: Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Tao Wei ◽  
Cancan Li ◽  
Yuanyuan Heng ◽  
Xiang Gao ◽  
Guimei Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work

Is shift-work associated with increased risk of rectal cancer? A meta-analysis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e15600-e15600
Author(s):  
Chenyu Sun ◽  
Ce Cheng ◽  
Kelly Kozma ◽  
Gopika Chandra ◽  
Na Hyun Kim ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Risk ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Fixed Effect Model ◽  
Night Shift Work ◽  
Increased Risk ◽  
Rotating Shift Work ◽  
Trim And Fill

e15600 Background: Globally, more than 1.8 million people were diagnosed of colorectal cancer (CRC) in 2018, with over 30% of CRC in the rectum. Shift-work, involving circadian disruption, sleep deprivation and lifestyle changes, was designated as a probable cause of cancer by The International Agency for Research on Cancer. Previous studies investigating the impact of permanent night-shift work and rotating shift-work on rectal cancer risk showed controversial results. Thus, this meta-analysis was conducted. Methods: A comprehensive literature search on PubMed was conducted to identify all relevant studies published prior to January 2021 according to the established inclusion criteria. The quality assessment was performed by the Newcastle-Ottawa Scale (NOS). The pooled odds ratio (OR) and 95% confidence intervals (CI) were calculated to estimate the association between the shift-work and rectal cancer risk. Based on heterogeneity significance, random-effect or fixed-effect model was used. Subgroup analyses were conducted to explore the night-shift and rotating-shift, respectively. Sensitivity analysis and publication bias detection were performed, and trim and fill analysis was also conducted. All statistical analyses were performed using RevMan software (version 5.3; Cochrane library) and STATA 15.0 statistical software (Stata Corp., College Station, TX), and all P values were two-tailed, the test level was 0.05. Results: Thirty-seven articles were obtained from database searching. Three articles involving 1,063 rectal cancer cases were included. All studies were considered moderate to high quality. All included studies investigated on the association between shift-work and rectal cancer risk. A statistically significant association between shift-work and increased rectal cancer risk was found (OR 1.53, 95%CI: 1.31, 1.79, P< 0.00001, I 2 = 35%). In subgroup analyses, night-shift work was associated with a non-statistically significant increased risk of rectal cancer (OR 1.25, 95%CI: 0.47, 3.32, P = 0.66, I 2 = 93%). In contrast, Rotating-shift was associated with a statistically significant increased rectal cancer risk (OR 1.35, 95%CI: 1.10, 1.65, P = 0.004, I 2 = 6%). Sensitivity analysis confirmed the stability of the result. Funnel plot, Egger's test (t = 1.69, P = 0.341), and Begg's test (z = 1.04, P = 0.296) found no publication bias of analysis. Trim and fill analysis on fixed-effect model showed the pooled OR kept stable after adding two “missing” studies (OR 1.403, 95%CI: 1.224, 1.609, P <0.05). Conclusions: The current meta-analysis demonstrates that shift-work is associated with increased rectal cancer risk. However, no association between night-shift work and rectal cancer risk was found. In contrast, association between rotating-shift work and increased rectal cancer risk was found. More original studies on this topic are needed to further explore shift-work impacts on rectal cancer risk.

scholarly journals Night-shift work and breast cancer – a systematic review and meta-analysis

2013 ◽  
Vol 39 (5) ◽  
pp. 431-447 ◽  
Author(s):  
Sharea Ijaz Ijaz ◽  
Jos H Verbeek ◽  
Andreas Seidler ◽  
Marja-Liisa Lindbohm ◽  
Anneli Ojajärvi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work

Is shift-work associated with increased risk of esophageal cancer for males? A meta-analysis.

2021 ◽  
Vol 39 (3_suppl) ◽  
pp. 190-190
Author(s):  
Chenyu Sun ◽  
Ce Cheng
Keyword(s):  
Sensitivity Analysis ◽  
Esophageal Cancer ◽  
Cancer Risk ◽  
Publication Bias ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work ◽  
Increased Risk ◽  
Subgroup Analyses

190 Background: Globally, more than 570,000 people are diagnosed of esophageal cancer each year. Shift-work involving circadian disruption was designated as a probable cause of cancer by The International Agency for Research on Cancer. Previous studies investigating the relationship between shift-work and esophageal cancer among showed controversial results. Thus, this meta-analysis was conducted. Methods: A comprehensive literature search on PubMed was conducted to identify all relevant studies published prior to September 2020 according to the established inclusion criteria. The quality assessment was performed by the Newcastle-Ottawa Scale (NOS). The pooled odds risk (OR) and 95% confidence intervals (CI) were calculated to estimate the association between the shift-work and esophageal cancer risk. Random-effect or fixed-effect model was used to calculate the pooled OR, based on heterogeneity significance. Subgroup analyses were conducted based on night-shift versus rotating-shift. Sensitivity analysis and publication bias detection were also performed. All statistical analyses were performed using RevMan software (version 5.3; Cochrane library) and STATA 12.0 statistical software (Stata Corp., College Station, TX), and all P values were two-tailed, the test level was 0.05. Results: 21 articles were obtained from database searching, and 9 articles were obtained from other sources. 3 articles involving 52,098 participants were included. All studies were considered moderate to high quality. All included studies investigated only males on the association between shift-work and esophageal cancer risk. A statistically significant association between shift-work and increased esophageal cancer risk among males was found (OR 2.09, 95%CI: 1.48, 2.94, P< 0.0001, I 2= 29%). In subgroup analyses, night-shift work was associated with a non-statistically significant increased risk of esophageal cancer (OR 1.56, 95%CI: 0.96, 2.53, P= 0.07, I 2= 0%). In contrast, Rotating-shift was associated with increased esophageal cancer risk (OR 2.80, 95%CI: 1.72, 4.57, P < 0.0001, I 2= 0%). Sensitivity analysis confirmed the stability of the result. Funnel plot, Egger's test, and Begg's test found no publication bias of analysis (P = 0.572). Conclusions: The current meta-analysis demonstrates that shift-work is associated with increased esophageal cancer risk for males. However, no association between night-shift work and esophageal cancer risk was found. In contrast, association between rotating-shift work and increased esophageal cancer risk was found. Original studies on females regarding shift-work and esophageal cancer risk are lacking. More original studies on this topic for both male and female are needed to further explore shift-work impacts on esophageal cancer risk.

Night-shift work and risk of breast cancer: a systematic review and meta-analysis

2013 ◽  
Vol 138 (1) ◽  
pp. 291-301 ◽  
Author(s):  
Biren B. Kamdar ◽  
Ana I. Tergas ◽  
Farrah J. Mateen ◽  
Neil H. Bhayani ◽  
Jiwon Oh
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work

scholarly journals Night-shift work duration and breast cancer risk: an updated systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
E. Manouchehri ◽  
A. Taghipour ◽  
V. Ghavami ◽  
A. Ebadi ◽  
F. Homaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Shift Work ◽  
Night Shift ◽  
Short Term ◽  
Shift Workers ◽  
Night Shift Work

Abstract Background The International Agency for Research on Cancer (IARC) has classified shift work as a possible human carcinogen. The results of systematic on this topic is contradictory. This systematic review and meta-analysis, therefore, aimed to update the current evidence regarding the relationship between night-shift work duration and breast cancer risk. Methods PubMed, Web of Science, and Scopus as well as reference list of included studies were searched until December 19, 2020. Observational case–control or cohort studies investigating the relationship between the duration of night-shift work and breast cancer in women were included, which all quantified night-shift work exposure. All statistical analyses were done by Stata version 11.2. Results Our literature search was resulted in retrieval of 4854 publications from which 26 eligible studies with 1,313,348 participants were included in the meta-analyses. The pooled relative risk (RR) and 95% confidence intervals (CIs) of breast cancer for short-term night-shift workers (< 10 years) was 1.13 (95% CI 1.03–1.24, p = 0.008, I2 = 71.3%), and for long-term night-shift workers (≥ 10 years) was 1.08 (95% CI 0.99–1.17, p = 0.09, I2 = 42.2%), with moderate to substantial statistical heterogeneity observed in both analyses. The results of subgroup analysis showed that flight attendants with long overnight flights were at an elevated risk of breast cancer, but unmeasured confounders limited these results. The risk of breast cancer in case control studies, adjusted for reproductive factors and family history of breast cancer as well as studies with high quality was increased in both short term and long term night-shift workers. Conclusions This systematic review found a positive statistical relationship between night work and breast cancer risk in short-term night-shift workers but no increase was observed in the long-term night-shift workers.

scholarly journals Response to Ijaz S, et al. “Night-shift work and breast cancer - a systematic review and meta-analysis”

2013 ◽  
Vol 39 (6) ◽  
pp. 631-632 ◽  
Author(s):  
Richard G Stevens ◽  
Johnni Hansen ◽  
Eva S Schernhammer ◽  
Scott Davis
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work

scholarly journals Response to Letter to the Editor, re: Ijaz S, et al. “Night-shift work and breast cancer – a systematic review and meta-analysis”

2013 ◽  
Vol 39 (6) ◽  
pp. 633-634 ◽  
Author(s):  
Sharea Ijaz ◽  
Jos Verbeek ◽  
Andreas Seidler ◽  
Marja-Liisa Lindbohm ◽  
Anneli Ojajärvi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Night Shift Work ◽  
Letter To The Editor

scholarly journals Sex Differences in the Association between Night Shift Work and the Risk of Cancers: A Meta-Analysis of 57 Articles

2018 ◽  
Vol 2018 ◽  
pp. 1-20 ◽  
Author(s):  
Wen Liu ◽  
Zhonghan Zhou ◽  
Dahai Dong ◽  
Lijiang Sun ◽  
Guiming Zhang
Keyword(s):  
Sex Differences ◽  
Cancer Risk ◽  
Shift Work ◽  
Meta Analysis ◽  
Night Shift ◽  
Case Control ◽  
Sensitivity Analyses ◽  
Response Analysis ◽  
Night Shift Work ◽  
Risk Of Cancer

Objectives. To identify the association between night shift work and the risk of various cancers with a comprehensive perspective and to explore sex differences in this association. Methods. We searched PubMed, Embase, and Web of Science for studies on the effect of night shift work on cancer, including case-control, cohort, and nested case-control studies. We computed risk estimates with 95% confidence intervals (CIs) in a random or fixed effects model and quantified heterogeneity using the I2 statistic. Subgroup, metaregression, and sensitivity analyses were performed to explore potential sources of heterogeneity. Contour-enhanced funnel plots and the trim and fill method were used together to analyze bias. Linear dose–response analysis was used to quantitatively estimate the accumulative effect of night shift work on the risk of cancer. Results. Fifty-eight studies were eligible for our meta-analysis, including 5,143,838 participants. In the random effects model, the pooled odds ratio (OR) of cancers was 1.15 (95% CI = 1.08–1.22, P<0.001; I2=76.2%). Night shift work increased the cancer risk in both men (OR = 1.14, 95% CI = 1.05–1.25, P=0.003) and women (OR = 1.12, 95% CI = 1.04–1.20, P=0.002). Subgroup analyses showed that night shift work positively increased the risk of breast (OR = 1.22, 95% CI = 1.08–1.38), prostate (OR = 1.26, 95% CI = 1.05–1.52), and digestive system (OR = 1.15, 95% CI = 1.01–1.32) cancers. For every 5 years of night shift work, the cancer risk increased by 3.2% (OR = 1.032, 95% CI = 1.013–1.051). Conclusion. This is the first meta-analysis identifying the positive association between night shift work and the risk of cancer and verifying that there is no sex difference in the effect of night shift work on cancer risk. Cancer risk increases with cumulative years of night shift work.

Sign in / Sign up

Export Citation Format

Share Document