scholarly journals Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis

2020 ◽  
Vol 10 ◽  
Author(s):  
Caterina Mancarella ◽  
Giulia Caldoni ◽  
Irene Ribolsi ◽  
Alessandro Parra ◽  
Maria Cristina Manara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ewing Sarcoma ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding ◽  
Cxcr4 Axis

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 is a Novel Post-Transcriptional Regulator of Ewing Sarcoma Malignancy

2018 ◽  
Vol 24 (15) ◽  
pp. 3704-3716 ◽  
Author(s):  
Caterina Mancarella ◽  
Michela Pasello ◽  
Selena Ventura ◽  
Andrea Grilli ◽  
Linda Calzolari ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ewing Sarcoma ◽  
Binding Protein ◽  
Transcriptional Regulator ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinwei Huang ◽  
Hong Zhang ◽  
Xiaoran Guo ◽  
Zongxin Zhu ◽  
Haibo Cai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

The roles of Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3) in melanoma progression

2013 ◽  
Vol 69 (2) ◽  
pp. e20-e21
Author(s):  
Chia-Yu Chu ◽  
Yi-Shuan Sheen ◽  
Kuanyin K. Lin ◽  
Meng-Chen Hsieh ◽  
Hsien-Ching Chiu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Messenger Rna ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Melanoma Progression ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals Expression and prognostic analyses of the insulin-like growth factor 2 mRNA binding protein family in human pancreatic cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiao-Han Cui ◽  
Shu-Yi Hu ◽  
Chun-Fu Zhu ◽  
Xi-Hu Qin
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Growth Factor ◽  
Binding Protein ◽  
Gene Set Enrichment Analysis ◽  
Human Pancreatic Cancer ◽  
Insulin Like Growth Factor ◽  
Expression Levels ◽  
Mrna Binding Protein ◽  
Mrna Binding

Abstract Background Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involved in a variety of human malignant tumours. However, little is known about their expression and prognostic value in human pancreatic cancer. Therefore, we performed a detailed cancer versus normal differential analysis. Methods The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) databases were used to analyse the mRNA expression levels of the IGF2BP family in various cancers, including pancreatic cancer. Then, the LinkedOmics and GEPIA databases were used to assess the relation between the expression levels of IGF2BPs and overall survival (OS). Then, univariate and multivariate Cox regression analyses were performed, and subgroups based on grade and stage were analysed. The signalling pathways associated with IGF2BP2 and IGF2BP3 were then investigated via gene set enrichment analysis (GSEA). Results IGF2BP2 and IGF2BP3 were associated with each subset of OS based on grade and stage. Further clinical correlation analysis of IGF2BP2 and IGF2BP3 confirmed that IGF2BP2 and IGF2BP3 are fundamental factors in promoting pancreatic cancer progression. Conclusion IGF2BP2 and IGF2BP3 are key factors in promoting the progression of pancreatic cancer and are closely related to overall survival.

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