scholarly journals Breast Cancer With a HER2 IHC2+ and FISH HER2/CEP17 Ratio ≥2.0 and an Average HER2 Gene Copy Number <4.0 per Tumor Cell: HER2 mRNA Overexpression Is a Rare Event

2020 ◽  
Vol 10 ◽  
Author(s):  
Yuanyuan Liu ◽  
Shafei Wu ◽  
Xiaohua Shi ◽  
Feng Mao ◽  
Xuan Zeng
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Copy Number ◽  
Rare Event ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Her2 Gene ◽  
Her2 Mrna

Prognostic role of plasma HER2 gene copy number in patients with HER2 positive metastatic breast cancer.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e13018-e13018 ◽  
Author(s):  
Ran Ran ◽  
Wenfa Huang ◽  
Shao Lin ◽  
Yunyun Niu ◽  
Hope S. Rugo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Copy Number ◽  
Gene Copy Number ◽  
Metastatic Breast ◽  
Gene Copy ◽  
Prognostic Role ◽  
Her2 Gene ◽  
Her2 Positive

scholarly journals Prognostic Value of Plasma HER2 Gene Copy Number in HER2-Positive Metastatic Breast Cancer Treated with First-Line Trastuzumab

2020 ◽  
Vol Volume 13 ◽  
pp. 4385-4395 ◽  
Author(s):  
Ran Ran ◽  
Wenfa Huang ◽  
Yaxin Liu ◽  
Lin Shao ◽  
Xiaoran Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Copy Number ◽  
Prognostic Value ◽  
Gene Copy Number ◽  
Metastatic Breast ◽  
Gene Copy ◽  
First Line ◽  
Her2 Gene ◽  
Her2 Positive

scholarly journals Nongenotoxic ABCB1 activator tetraphenylphosphonium can contribute to doxorubicin resistance in MX-1 breast cancer cell line

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Raimonda Kubiliute ◽  
Indre Januskeviciene ◽  
Ruta Urbanaviciute ◽  
Kristina Daniunaite ◽  
Monika Drobniene ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Protein Level ◽  
Copy Number ◽  
Gene Copy Number ◽  
Gene Copy ◽  
Common Mechanism ◽  
Dna Hypomethylation ◽  
Mesenchymal Transition ◽  
Molecular Features

AbstractHyperactivation of ABC transporter ABCB1 and induction of epithelial–mesenchymal transition (EMT) are the most common mechanism of acquired cancer chemoresistance. This study describes possible mechanisms, that might contribute to upregulation of ABCB1 and synergistically boost the acquisition of doxorubicin (DOX) resistance in breast cancer MX-1 cell line. DOX resistance in MX-1 cell line was induced by a stepwise increase of drug concentration or by pretreatment of cells with an ABCB1 transporter activator tetraphenylphosphonium (TPP+) followed by DOX exposure. Transcriptome analysis of derived cells was performed by human gene expression microarrays and by quantitative PCR. Genetic and epigenetic mechanisms of ABCB1 regulation were evaluated by pyrosequencing and gene copy number variation analysis. Gradual activation of canonical EMT transcription factors with later activation of ABCB1 at the transcript level was observed in DOX-only treated cells, while TPP+ exposure induced considerable activation of ABCB1 at both, mRNA and protein level. The changes in ABCB1 mRNA and protein level were related to the promoter DNA hypomethylation and the increase in gene copy number. ABCB1-active cells were highly resistant to DOX and showed morphological and molecular features of EMT. The study suggests that nongenotoxic ABCB1 inducer can possibly accelerate development of DOX resistance.

scholarly journals Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer

2014 ◽  
Vol 74 (17) ◽  
pp. 4853-4863 ◽  
Author(s):  
David Endesfelder ◽  
Rebecca A. Burrell ◽  
Nnennaya Kanu ◽  
Nicholas McGranahan ◽  
Mike Howell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Copy Number ◽  
Chromosomal Instability ◽  
Copy Number Variants ◽  
Gene Copy Number ◽  
Gene Copy

scholarly journals Clinical array-based karyotyping of breast cancer with equivocal HER2 status resolves gene copy number and reveals chromosome 17 complexity

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Shelly Gunn ◽  
I-Tien Yeh ◽  
Irina Lytvak ◽  
Budi Tirtorahardjo ◽  
Natasha Dzidic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Copy Number ◽  
Gene Copy Number ◽  
Chromosome 17 ◽  
Gene Copy ◽  
Her2 Status

Abstract B59: MET gene copy number related to radiation treatment response and prognosis in breast cancer

2012 ◽  
Vol 18 (10 Supplement) ◽  
pp. B59-B59
Author(s):  
Cynthia Veenstra ◽  
Gizeh Pérez-Tenorio ◽  
Tommy Fornander ◽  
Bo Nordenskjöld ◽  
Olle Stål
Keyword(s):  
Breast Cancer ◽  
Treatment Response ◽  
Copy Number ◽  
Radiation Treatment ◽  
Gene Copy Number ◽  
Gene Copy
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