scholarly journals Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma

2019 ◽  
Vol 9 ◽  
Author(s):  
Li Che ◽  
Panagiotis Paliogiannis ◽  
Antonio Cigliano ◽  
Maria G. Pilo ◽  
Xin Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Human Hepatocellular Carcinoma ◽  
Therapeutic Role

Antiangiogenics and Hypoxic Response: Role of Fatty Acid Synthase Inhibitors

2016 ◽  
Vol 17 (15) ◽  
pp. 1735-1746 ◽  
Author(s):  
Maria Jose Bueno ◽  
Jesus Sanchez ◽  
Ramon Colomer ◽  
Miguel Quintela-Fandino
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Hypoxic Response

OC.04.6 EARLY DETECTION OF METACHRONOUS COLORECTAL CANCER: THE ROLE OF FATTY ACID SYNTHASE (FASN)

2016 ◽  
Vol 48 ◽  
pp. e85
Author(s):  
C. Riga ◽  
E. Corazziari ◽  
R. Murari ◽  
G. Pedullà ◽  
A. Pronio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acid ◽  
Early Detection ◽  
Fatty Acid Synthase ◽  
Metachronous Colorectal Cancer

scholarly journals Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes

1998 ◽  
Vol 274 (3) ◽  
pp. E493-E501 ◽  
Author(s):  
F. Bradley Hillgartner ◽  
Tina Charron
Keyword(s):  
Fatty Acid ◽  
High Fat Diet ◽  
Malic Enzyme ◽  
Fatty Acid Synthase ◽  
Primary Cultures ◽  
Pentose Phosphate ◽  
Mrna Abundance ◽  
Low Fat Diet ◽  
Low Carbohydrate

Transcription of fatty acid synthase (FAS) and malic enzyme (ME) in avian liver is low during starvation or feeding a low-carbohydrate, high-fat diet and high during feeding a high-carbohydrate, low-fat diet. The role of glucose in the nutritional control of FAS and ME was investigated by determining the effects of this metabolic fuel on expression of FAS and ME in primary cultures of chick embryo hepatocytes. In the presence of triiodothyronine, glucose (25 mM) stimulated an increase in the activity and mRNA abundance of FAS and ME. These effects required the phosphorylation of glucose to glucose 6-phosphate but not further metabolism downstream of the aldolase step of the glycolytic pathway. Xylitol mimicked the effects of glucose on FAS and ME expression, suggesting that an intermediate of the pentose phosphate pathway may be involved in mediating this response. The effects of glucose on the mRNA abundance of FAS and ME were accompanied by similar changes in transcription of FAS and ME. These data support the hypothesis that glucose plays a role in mediating the effects of nutritional manipulation on transcription of FAS and ME in liver.

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