scholarly journals PD-1/PD-L1 Axis, Rather Than High-Mobility Group Alarmins or CD8+ Tumor-Infiltrating Lymphocytes, Is Associated With Survival in Head and Neck Squamous Cell Carcinoma Patients Who Received Surgical Resection

2018 ◽  
Vol 8 ◽  
Author(s):  
Fan Yang ◽  
Ziqing Zeng ◽  
Jing Li ◽  
Yu Zheng ◽  
Feng Wei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Surgical Resection ◽  
Squamous Cell ◽  
High Mobility ◽  
Tumor Infiltrating Lymphocytes ◽  
Neck Squamous Cell Carcinoma ◽  
High Mobility Group ◽  
Infiltrating Lymphocytes

scholarly journals Prognostic Significance of CD4+ and CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 781
Author(s):  
Daniele Borsetto ◽  
Michele Tomasoni ◽  
Karl Payne ◽  
Jerry Polesel ◽  
Alberto Deganello ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Tumor Infiltrating Lymphocytes ◽  
Neck Squamous Cell Carcinoma ◽  
Risk Of Death ◽  
Infiltrating Lymphocytes

Objective: It has been suggested that the presence of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment is associated with a better prognosis in different types of cancer. In this systematic review and meta-analysis, we investigated the prognostic role of CD4+ and CD8+ TILs in head and neck squamous cell carcinoma (HNSCC). Methods: PubMed, Cochrane, Embase, Scopus, and Web of Science were searched up to September 2020. This study was conducted following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) checklist. Risk ratios from individual studies were displayed in forest plots and the pooled hazard ratios (HR) of death and corresponding confidence intervals (CI) were calculated according to random-effects models. Risk of bias of the included studies was assessed through the Newcastle–Ottawa scale. Results: 28 studies met the inclusion criteria. Studies conducted on HNSCC subsites combined reported a significant reduction in the risk of death for both high CD4+ (HR: 0.77; 95% CI: 0.65–0.93) and high CD8+ TILs (HR: 0.64; 95% CI: 0.47–0.88). High CD4+ TILs were associated with significantly better overall survival among oropharyngeal HNSCC (HR: 0.52; 95% CI: 0.31–0.89), as well as high CD8+ TILS in Human papillomavirus −ve and +ve cancers (HR: 0.39; 95% CI: 0.16–0.93 and HR: 0.40; 95% CI 0.21–0.76 respectively). CD8+ TILs were also associated with improved survival in hypopharyngeal cancers (HR = 0.43 CI: 0.30–0.63). No significant association emerged for patients with cancer of the oral cavity or larynx. Conclusions: The findings from this meta-analysis demonstrate the prognostic significance of CD8+ and CD4+ TILs in HNSCC and variation in tumor subsite warrants further focused investigation. We highlight how TILs may serve as predictive biomarkers to risk stratify patients into treatment groups, with applications in immune-checkpoint inhibitors notable areas for further research.

scholarly journals Silencing of high-mobility group box 2 (HMGB2) modulates cisplatin and 5-fluorouracil sensitivity in head and neck squamous cell carcinoma

PROTEOMICS ◽  
2015 ◽  
Vol 15 (2-3) ◽  
pp. 383-393 ◽  
Author(s):  
Nazia Syed ◽  
Sandip Chavan ◽  
Nandini A. Sahasrabuddhe ◽  
Santosh Renuse ◽  
Gajanan Sathe ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
High Mobility ◽  
Neck Squamous Cell Carcinoma ◽  
High Mobility Group

scholarly journals Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma: A Focus on Tumor-Infiltrating Lymphocytes

2019 ◽  
Vol 4 (2) ◽  
pp. 19-26
Author(s):  
Marzieh Norouzian ◽  
Sima Balouchi-Anaraki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Tumor Microenvironment ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Markers ◽  
Tumor Infiltrating Lymphocytes ◽  
Neck Squamous Cell Carcinoma ◽  
Infiltrating Lymphocytes

For more progress in head and neck squamous cell carcinoma (HNSCC) immuno-oncology, further understanding of interactions between tumor and immune system as well as factors in the tumor microenvironment is required. HNSCC is seriously infiltrated by lymphocytes but is known to be highly immunosuppressive. The aim of this review is to highlight the complexity of tumor microenvironment and tumor- immune cells interaction in the HNSCC, in order to improve understanding of tumorigenesis and disease progression in HNSCC patient and to provide valuable information about prognostic markers. The main goal of this review is to discuss the role of the tumor infiltrating lymphocytes in tumor progression, their cross-talk with other components of the tumor microenvironment as well as their roles in carcinogenesis, metastasis process, treatment, and prognosis in head and neck squamous cell carcinomas.

scholarly journals Tumor infiltrating lymphocytes and survival in patients with head and neck squamous cell carcinoma

Head & Neck ◽  
2016 ◽  
Vol 38 (7) ◽  
pp. 1074-1084 ◽  
Author(s):  
Nghia Nguyen ◽  
Emily Bellile ◽  
Daffyd Thomas ◽  
Jonathan McHugh ◽  
Laura Rozek ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Infiltrating Lymphocytes ◽  
Neck Squamous Cell Carcinoma ◽  
Infiltrating Lymphocytes
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