scholarly journals Comparison of Functional Outcome after Extended versus Super-Extended Pelvic Lymph Node Dissection during Radical Prostatectomy in High-Risk Localized Prostate Cancer

2017 ◽  
Vol 7 ◽  
Author(s):  
Heikki Seikkula ◽  
Pieter Janssen ◽  
Manuela Tutolo ◽  
Lorenzo Tosco ◽  
Antonino Battaglia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Functional Outcome ◽  
Lymph Node Dissection ◽  
Pelvic Lymph Node Dissection ◽  
Pelvic Lymph Node ◽  
Localized Prostate Cancer ◽  
Node Dissection

scholarly journals External validation of the Briganti 2019 nomogram to identify candidates for extended pelvic lymph node dissection among patients with high-risk clinically localized prostate cancer

2021 ◽  
Author(s):  
Eri Fukagawa ◽  
Shinya Yamamoto ◽  
Sachiko Ohde ◽  
Kasumi Kaneko Yoshitomi ◽  
Kosuke Hamada ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Lymph Node Dissection ◽  
External Validation ◽  
Pelvic Lymph Node Dissection ◽  
Pelvic Lymph Node ◽  
Localized Prostate Cancer ◽  
Node Dissection ◽  
Characteristic Analysis

Abstract Background We aimed to establish an external validation of the Briganti 2019 nomogram in a Japanese cohort to preoperatively evaluate the probability of lymph node invasion in patients with high-risk, clinically localized prostate cancer. Methods The cohort consisted of 278 patients with prostate cancer diagnosed using magnetic resonance imaging-targeted biopsy who underwent radical prostatectomy and extended pelvic lymph node dissection from 2012 to 2020. Patients were rated using the Briganti 2019 nomogram, which evaluates the probability of lymph node invasion. We used the area under curve of the receiver operating characteristic analysis to quantify the accuracy of the nomogram. Results Nineteen (6.8%) patients had lymph node invasion. The median number of lymph nodes removed was 18. The area under the curve for the Briganti 2019 was 0.71. When the cutoff was set at 7%, 84 (30.2%) patients with extended pelvic lymph node dissection could be omitted, and only 1 (1.2%) patient with lymph node invasion would be missed. Sensitivity, specificity, and negative predictive values at the 7% cutoff were 94.7, 32.0, and 98.8%, respectively. Conclusion This external validation showed that the Briganti 2019 nomogram was accurate, although there may still be scope for individual adjustments.

Sign in / Sign up

Export Citation Format

Share Document