scholarly journals Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk

2016 ◽  
Vol 6 ◽  
Author(s):  
Joy Shi ◽  
Kristan J. Aronson ◽  
Anne Grundy ◽  
Lindsay C. Kobayashi ◽  
Igor Burstyn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Insulin Like Growth Factor

scholarly journals Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

2016 ◽  
Vol 88 (4) ◽  
pp. 2349-2356 ◽  
Author(s):  
DANYLO R. COSTA-SILVA ◽  
MARIA DA CONCEIÇÃO BARROS-OLIVEIRA ◽  
RAFAEL S. BORGES ◽  
CLÉCITON B. TAVARES ◽  
UMBELINA S. BORGES ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Gene Polymorphism ◽  
Insulin Like Growth Factor

Reports: Insulin-Like Growth Factor-I, Soy Protein Intake, and Breast Cancer Risk

2004 ◽  
Vol 50 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Maureen Sanderson ◽  
Xiao Ou Shu ◽  
Herbert Yu ◽  
Qi Dai ◽  
Alecia S. Malin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Soy Protein ◽  
Protein Intake ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and breast cancer risk: observational and Mendelian randomization analyses

2019 ◽  
Author(s):  
Neil Murphy ◽  
Anika Knuppel ◽  
Nikos Papadimitriou ◽  
Richard M Martin ◽  
Konstantinos K Tsilidis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
World Health ◽  
International Agency ◽  
Insulin Like Growth Factor ◽  
Health Organization ◽  
The Uk ◽  
Igfbp 3

AbstractBackgroundEpidemiological evidence supports a positive association between circulating insulin-like growth factor-1 (IGF-1) concentrations and breast cancer risk, but both the magnitude and causality of this relationship are uncertain. We conducted observational analyses with adjustment for regression dilution bias, and Mendelian randomization (MR) analyses to allow causal inference.Patients and methodsWe investigated the associations between circulating IGF-1 concentrations and incident breast cancer risk in 206,263 women in the UK Biobank. Multivariable hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. HRs were corrected for regression dilution using repeat IGF-1 measures available in a subsample of 6,711 women. For the MR analyses, genetic variants associated with circulating IGF-1 and IGFBP-3 levels were identified and their association with breast cancer was examined with two-sample MR methods using genome-wide data from 122,977 cases and 105,974 controls.ResultsIn the UK Biobank, after a median follow-up of 7.1 years, 4,360 incident breast cancer cases occurred. In the multivariable-adjusted models corrected for regression dilution, higher IGF-1 concentrations were associated with a greater risk of breast cancer (HR per 5 nmol/L increment of IGF-1=1.11, 95%CI=1.07-1.16). Similar positive associations were found by follow-up time, menopausal status, body mass index, and other risk factors. In the MR analyses, a 5 nmol/L increment in genetically-predicted IGF-1 concentration was associated with greater breast cancer risk (odds ratio [OR]=1.05, 95%CI=1.01-1.10; Pvalue=0.02), with a similar effect estimate for estrogen positive (ER+) tumors, but no effect found for estrogen negative (ER-) tumors. Genetically-predicted IGFBP-3 concentrations were not associated with breast cancer risk (OR per 1-SD increment=1.00, 95%CI=0.97-1.04; Pvalue=0.98).ConclusionOur results support a probable causal relationship between circulating IGF-1 concentrations and breast cancer, suggesting that interventions targeting the IGF pathway may be beneficial in preventing breast tumorigenesis.DisclaimerWhere authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization.

scholarly journals Biomarkers of Insulin and the Insulin-Like Growth Factor Axis in Relation to Breast Cancer Risk in Chinese Women

2020 ◽  
Vol Volume 13 ◽  
pp. 8027-8036
Author(s):  
Yifei Zhu ◽  
Tiange Wang ◽  
Jiayi Wu ◽  
Ou Huang ◽  
Li Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chinese Women ◽  
Insulin Like Growth Factor
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