scholarly journals Structures and Metabolic Properties of Bovine Milk Oligosaccharides and Their Potential in the Development of Novel Therapeutics

2019 ◽  
Vol 6 ◽  
Author(s):  
Randall C. Robinson
Keyword(s):  
Bovine Milk ◽  
Milk Oligosaccharides ◽  
Novel Therapeutics ◽  
Metabolic Properties

scholarly journals Bovine Milk Oligosaccharides with Sialyllactose for Preterm Piglets

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1489 ◽  
Author(s):  
Karina Obelitz-Ryom ◽  
Amalie Rendboe ◽  
Duc Nguyen ◽  
Silvia Rudloff ◽  
Anne Brandt ◽  
...  
Keyword(s):  
Bacterial Colonization ◽  
Bovine Milk ◽  
Protective Effects ◽  
Gut Development ◽  
Artificial Rearing ◽  
Milk Oligosaccharides ◽  
Term Infants ◽  
Brain Functions ◽  
Near Term ◽  
Dietary Treatments

Oligosaccharides support gut development and bacterial colonization in term infants, but it is unknown if they benefit preterm infants. Using preterm pigs, we investigated effects of bovine milk supplements enriched with oligosaccharides to improve gut development and colonization. Caesarean-delivered preterm pigs (n = 57) were reared for 19 days. The pigs were fed bovine milk supplemented with an oligosaccharide-enriched whey containing sialyllactose, or a heterogeneous oligosaccharide ingredient. To evaluate the influence of artificial rearing, near-term, vaginally born pigs raised by their sow (n = 12) were compared with artificially reared, caesarean-delivered near-term pigs (n = 14). In preterm pigs, the clinical outcome, gut function, gut microbiota, and systemic immunity were similar among dietary treatments. Natural rearing increased growth rates, gut functions, colon short chain fatty acid concentrations and bacterial diversity, relative to artificial rearing. In conclusion, supplements with bovine milk oligosaccharides were well tolerated, but did not improve gut maturation or clinical outcomes in artificially reared preterm piglets. Immaturity at birth, coupled with artificial rearing, may render the neonate unresponsive to the gut-protective effects of milk oligosaccharides. Whether bovine milk oligosaccharides may affect other endpoints (e.g., brain functions) in conditions of immaturity remains to be investigated.

scholarly journals Tolerability and safety of the intake of bovine milk oligosaccharides extracted from cheese whey in healthy human adults

2017 ◽  
Vol 6 ◽  
Author(s):  
Jennifer T. Smilowitz ◽  
Danielle G. Lemay ◽  
Karen M. Kalanetra ◽  
Elizabeth L. Chin ◽  
Angela M. Zivkovic ◽  
...  
Keyword(s):  
Bovine Milk ◽  
Evolutionary Relationship ◽  
Microbial Metabolism ◽  
Stool Consistency ◽  
Placebo Control ◽  
Resonance Spectroscopy ◽  
Faecal Microbiota ◽  
Milk Oligosaccharides ◽  
Healthy Human ◽  
Bacterial Populations

AbstractMechanistic research suggests a unique evolutionary relationship between complex milk oligosaccharides and cognate bifidobacteria enriched in breast-fed infants. Bovine milk oligosaccharides (BMO) were recently identified as structurally and functionally similar to human milk oligosaccharides. The present single-blind three-way crossover study is the first to determine the safety and tolerability of BMO consumption by healthy human participants (n 12) and its effects on faecal microbiota and microbial metabolism. Participants consumed each supplement (placebo-control; low- and high-BMO doses) for eleven consecutive days, followed by a 2-week washout period prior to initiating the next supplement arm. Low and high BMO doses were consumed as 25 and 35 % of each individual's daily fibre intake, respectively. Safety and tolerability were measured using standardised questionnaires on gut and stomach discomfort and stool consistency. Faecal extracts were profiled for bacterial populations by next-generation sequencing (NGS) and bifidobacteria presence was confirmed using quantitative PCR. Urine was analysed for changes in microbial metabolism using nuclear magnetic resonance spectroscopy (1H-NMR). Consumption of both the low and high BMO doses was well tolerated and did not change stool consistency from baseline. Multivariate analysis of the NGS results demonstrated no change in faecal microbiota phyla among the placebo-control and BMO supplement groups. In conclusion, BMO supplementation was well tolerated in healthy adults and has the potential to shift faecal microbiota toward beneficial strains as part of a synbiotic treatment with probiotic cultures that selectively metabolise oligosaccharides.

scholarly journals Profiling of aminoxyTMT-labeled bovine milk oligosaccharides reveals substantial variation in oligosaccharide abundance between dairy cattle breeds

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Randall C. Robinson ◽  
Nina A. Poulsen ◽  
Emeline Colet ◽  
Chloe Duchene ◽  
Lotte Bach Larsen ◽  
...  
Keyword(s):  
Dairy Cattle ◽  
Bovine Milk ◽  
Substantial Variation ◽  
Milk Oligosaccharides ◽  
Cattle Breeds

scholarly journals An integrated bioprocess to recover bovine milk oligosaccharides from colostrum whey permeate

2018 ◽  
Vol 216 ◽  
pp. 27-35 ◽  
Author(s):  
Juliana M.L.N. de Moura Bell ◽  
Joshua L. Cohen ◽  
Leticia F.M.C. de Aquino ◽  
Hyeyoung Lee ◽  
Vitor L. de Melo Silva ◽  
...  
Keyword(s):  
Bovine Milk ◽  
Milk Oligosaccharides ◽  
Whey Permeate ◽  
Integrated Bioprocess

scholarly journals Comparison of bovine milk oligosaccharides in native North European cattle breeds

2021 ◽  
Vol 114 ◽  
pp. 104917
Author(s):  
Anne Vuholm Sunds ◽  
Apichaya Bunyatratchata ◽  
Randall Robinson ◽  
Maria Glantz ◽  
Marie Paulsson ◽  
...  
Keyword(s):  
Bovine Milk ◽  
Milk Oligosaccharides ◽  
Cattle Breeds ◽  
European Cattle

scholarly journals Bovine milk oligosaccharides as anti-adhesives against the respiratory tract pathogen Streptococcus pneumoniae

2018 ◽  
Vol 81 ◽  
pp. 87-94 ◽  
Author(s):  
Joseph Thomas Ryan ◽  
Helen Slattery ◽  
Rita M. Hickey ◽  
Mariarosaria Marotta
Keyword(s):  
Streptococcus Pneumoniae ◽  
Respiratory Tract ◽  
Bovine Milk ◽  
Milk Oligosaccharides ◽  
Tract Pathogen

Lactose and Bovine Milk Oligosaccharides Synergistically StimulateB. longumsubsp.longumGrowth in a Simplified Model of the Infant Gut Microbiome

2019 ◽  
Vol 18 (8) ◽  
pp. 3086-3098 ◽  
Author(s):  
Louise M. A. Jakobsen ◽  
Ulrik K. Sundekilde ◽  
Henrik J. Andersen ◽  
Dennis S. Nielsen ◽  
Hanne C. Bertram
Keyword(s):  
Gut Microbiome ◽  
Bovine Milk ◽  
Simplified Model ◽  
Milk Oligosaccharides ◽  
Infant Gut Microbiome

scholarly journals Evaluation of 6′-Sialyllactose Sodium Salt Supplementation to Formula on Growth and Clinical Parameters in Neonatal Piglets

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1030 ◽  
Author(s):  
Marcia H. Monaco ◽  
Dae Hee Kim ◽  
Rit B. Gurung ◽  
Sharon M. Donovan
Keyword(s):  
Human Milk ◽  
Infant Formula ◽  
Sodium Salt ◽  
Large Scale ◽  
Hematological Parameters ◽  
Bovine Milk ◽  
Milk Replacer ◽  
Milk Oligosaccharides ◽  
Neonatal Piglets ◽  
Dose Dependent

Oligosaccharides are complex, non-digestible glycans found in large abundance in human milk. The abundance and the profile of bovine milk oligosaccharides and bovine milk based in infant formula differ from those in human milk. Recently, some human milk oligosaccharides (HMOs) have been supplemented to infant formula, however, not all forms have been available in large scale. The objective of the study was to investigate the dose-dependent effects of an enzymatically-synthesized 6′-sialyllactose (6′-SL) sodium salt supplemented to swine milk replacer on growth, hematological parameters, and organ microscopic assessment in our pre-clinical neonatal pig model. Two-day-old male and female pigs (n = 47) were provided one of four experimental diets for 21 days. Diets were formulated to contain 0 (CON), 300 (LOW), 600 (MOD), or 1200 (HIGH) mg/L of 6′-SL sodium salt. On days 8 and 22, samples were collected for hematological and histological analyses. Supplemental 6′-SL sodium salt at all doses supported growth and development comparable to those observed in control animals. In addition, serum chemistries, hematology, and organ microscopic structure were unaffected by 6′-SL (p > 0.05). Thus, addition of enzymatically-synthesized 6′-SL to a milk replacer formula supported growth and clinical outcomes similar to the control formula in the neonatal piglet.

scholarly journals Fecal metatranscriptomics and glycomics suggest that bovine milk oligosaccharides are fully utilized by healthy adults

2020 ◽  
Vol 79 ◽  
pp. 108340 ◽  
Author(s):  
Samuel T. Westreich ◽  
Jaime Salcedo ◽  
Blythe Durbin-Johnson ◽  
Jennifer T. Smilowitz ◽  
Ian Korf ◽  
...  
Keyword(s):  
Bovine Milk ◽  
Healthy Adults ◽  
Milk Oligosaccharides
Sign in / Sign up

Export Citation Format

Share Document